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PI3K inhibitors (idelalisib,copanlisib, duvelisib, parsaclisib, umbralisib, zandelisib, ACP-319) in CLL: where do we go from here?
While we have never been as spoiled for treatment choice as we are now, PI3K inhibitor safety is being very closely monitored by the FDA. So, it's timely that Sigrid S Skanland and Jennifer R Brown have written a peer-reviewed Haematologica early view paper that discusses [i]"the current status of
While we have never been as spoiled for treatment choice as we are now, PI3K inhibitor safety is being very closely monitored by the FDA. So, it's timely that Sigrid S Skanland and Jennifer R Brown have written a peer-reviewed Haematologica early view paper that discusses [i]"the current status of
CLLerinOz
Volunteer
in
CLL Support
2 years ago
I just bought this PEMF therapy mat (pulsed electromagnetic frequency) after learning it treats PD
PEMF is a very interesting therapy that's been around for decades. This is a 2015 study from the NIH https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562205/ [u]"Conclusions"[/u][i]
"Electromagnetic therapy opens a new avenue for PD treatment.
[/i] [i]Each electromagnetic therapy technique described
PEMF is a very interesting therapy that's been around for decades. This is a 2015 study from the NIH https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562205/ [u]"Conclusions"[/u][i]
"Electromagnetic therapy opens a new avenue for PD treatment.
[/i] [i]Each electromagnetic therapy technique described
PDWarrior1900
in
Cure Parkinson's
2 years ago
Israeli scientists developing ‘precision’ viruses that kill bowel-harming bacteria
[i]Illustrative image: Viruses, known as phages, infecting bacteria. The Weizmann Institute has developed pages which it says could counter harmful bacteria in the bowel. (libre de droit via iStock by Getty Images)[/i] In peer-reviewed study, Weizmann researchers tout ‘silver bullet’ approach promising
[i]Illustrative image: Viruses, known as phages, infecting bacteria. The Weizmann Institute has developed pages which it says could counter harmful bacteria in the bowel. (libre de droit via iStock by Getty Images)[/i] In peer-reviewed study, Weizmann researchers tout ‘silver bullet’ approach promising
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
2 years ago
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I called a suicide hotline today. I can't stand the pain.
It's a depressive and emotional pain but also manifests itself physically. My wife thinks it was triggered by our problems, especially when she went away last weekend. We need to do couples therapy but I don't know if I can handle it at the moment. I was able to go for a walk with my son today and play
It's a depressive and emotional pain but also manifests itself physically. My wife thinks it was triggered by our problems, especially when she went away last weekend. We need to do couples therapy but I don't know if I can handle it at the moment. I was able to go for a walk with my son today and play
Joshgw
in
Anxiety and Depression Support
2 years ago
AMPLITUDE clinical trial
Having been diagnosed with stage 4 PCa in May this year (see my profile for more details), my CO has suggested it could be worth me participating in the AMPLITUDE trial. This is currently at the stage of taking newly diagnosed metastatic cases like mine who have particular DNA repair defects. I don't
Having been diagnosed with stage 4 PCa in May this year (see my profile for more details), my CO has suggested it could be worth me participating in the AMPLITUDE trial. This is currently at the stage of taking newly diagnosed metastatic cases like mine who have particular DNA repair defects. I don't
Benkaymel
in
Advanced Prostate Cancer
2 years ago
Lonely
In 2020 I was diagnosed with both Fibromyalgia and Bipolar, I feel left in the dark about both conditions by my doctors (even though there I know there is no known cure for fibro) I've asked for therapy but the organisation seemed reluctant as I stopped m taking my medication because it was making me
In 2020 I was diagnosed with both Fibromyalgia and Bipolar, I feel left in the dark about both conditions by my doctors (even though there I know there is no known cure for fibro) I've asked for therapy but the organisation seemed reluctant as I stopped m taking my medication because it was making me
SaikiK
in
Above & Beyond
2 years ago
The Constitution of Knowledge (Part 3 of 3)
[u]
Distrust of Institutions
[/u] There has been growing distrust of institutions among lay people, sometimes with good reasons. There were abuses like “p-hacking” that fostered distrust. Until recently, publications did not require authors to be transparent about potential conflicts of interest
[u]
Distrust of Institutions
[/u] There has been growing distrust of institutions among lay people, sometimes with good reasons. There were abuses like “p-hacking” that fostered distrust. Until recently, publications did not require authors to be transparent about potential conflicts of interest
Tall_Allen
in
Prostate Cancer Network
2 years ago
The Constitution of Medical Knowledge (Part 3 of 3)
[u]
Distrust of Institutions
[/u] There has been growing distrust of institutions among lay people, sometimes with good reasons. There were abuses like “p-hacking” that fostered distrust. Until recently, publications did not require authors to be transparent about potential conflicts of interest
[u]
Distrust of Institutions
[/u] There has been growing distrust of institutions among lay people, sometimes with good reasons. There were abuses like “p-hacking” that fostered distrust. Until recently, publications did not require authors to be transparent about potential conflicts of interest
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Please help. Am I just making this up like my therapist says?
Possible Tw: mention of SH I have depression. I’ve been on anti depressants since I was 8. I’m going through huge life changes - my family wants nothing to do with me and is victim blaming me so I don’t even want to be associated with them either. They are extremely toxic and my mental health team
Possible Tw: mention of SH I have depression. I’ve been on anti depressants since I was 8. I’m going through huge life changes - my family wants nothing to do with me and is victim blaming me so I don’t even want to be associated with them either. They are extremely toxic and my mental health team
Ubud2021
in
Anxiety and Depression Support
2 years ago
New AI approach to Crohn’s disease diagnosis and treatment
[i]The Intel-Sheba team that developed an AI app for diagnosing Crohn’s. Photo by Ohad Falik[/i] Intel and Israel’s largest medical center develop algorithm that scans thousands of digestive system images in 2 minutes for improved prediction. By Abigail Klein Leichman AUGUST 2, 2022 Approximately
[i]The Intel-Sheba team that developed an AI app for diagnosing Crohn’s. Photo by Ohad Falik[/i] Intel and Israel’s largest medical center develop algorithm that scans thousands of digestive system images in 2 minutes for improved prediction. By Abigail Klein Leichman AUGUST 2, 2022 Approximately
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
2 years ago
Jarlsberg cheese may help stave off osteoporosis, small study suggests
K2 rides again! Ironically, the day after the dismissive vitamin D article in Forbes (which - as was pointed out - had no mention of K2). [i]
Jarlsberg cheese may help stave off osteoporosis, small study suggests
Jarlsberg is rich in vitamin K2, which has previously been found to improve
K2 rides again! Ironically, the day after the dismissive vitamin D article in Forbes (which - as was pointed out - had no mention of K2). [i]
Jarlsberg cheese may help stave off osteoporosis, small study suggests
Jarlsberg is rich in vitamin K2, which has previously been found to improve
helvella
Thyroid UK
in
Thyroid UK
2 years ago
Finishing line for Pirtobrutinib (Loxo) & Venetoclax combination trial.
I have just completed the 2 year combination clinical trial with Pirtobrutinib and Venetoclax - I think a small study of us in Australia. ( Also worldwide) This has resulted in no detectable cancer in my blood and lymph nodes- woohoo! My last Bone Marrow test showed just outside the non detectable parameter
I have just completed the 2 year combination clinical trial with Pirtobrutinib and Venetoclax - I think a small study of us in Australia. ( Also worldwide) This has resulted in no detectable cancer in my blood and lymph nodes- woohoo! My last Bone Marrow test showed just outside the non detectable parameter
Billarina
in
CLL Support
2 years ago
Good news to share!
After radical prostatectomy, chemo clinical trial, and radiation during 2001-2002, I watched my psa do its long slow climb. I began Lupron injections about five years ago. The number dropped to about 0.84, then began another long slow climb. After a PSMA PET scan revealed that there were "no distant
After radical prostatectomy, chemo clinical trial, and radiation during 2001-2002, I watched my psa do its long slow climb. I began Lupron injections about five years ago. The number dropped to about 0.84, then began another long slow climb. After a PSMA PET scan revealed that there were "no distant
Okay4now
in
Prostate Cancer Network
2 years ago
First Post
How do you guys deal with your
clinical
depression
? I've tried all kinds of coping skills and therapy, and nothing seems to work. I've been told it's just my mindset that makes none of it work. Which I'm sure is true. Do you guys have any suggestions for me?
How do you guys deal with your
clinical
depression
? I've tried all kinds of coping skills and therapy, and nothing seems to work. I've been told it's just my mindset that makes none of it work. Which I'm sure is true. Do you guys have any suggestions for me?
GreenTiger96
in
Anxiety and Depression Support
2 years ago
Anavex Announces First Entire Clinical Alzheimer's Gene Pathway Data of ANAVEX®2-73 at AAIC 2022 (both Alzheimer's and Parkinson's disease)
https://www.benzinga.com/pressreleases/22/07/g28280412/anavex-announces-first-entire-clinical-alzheimers-gene-pathway-data-of-anavex-2-73-at-aaic-2022 Expression levels of pathological dysregulated neurodegenerative genes of both Alzheimer's and Parkinson's disease were significantly restored by the
https://www.benzinga.com/pressreleases/22/07/g28280412/anavex-announces-first-entire-clinical-alzheimers-gene-pathway-data-of-anavex-2-73-at-aaic-2022 Expression levels of pathological dysregulated neurodegenerative genes of both Alzheimer's and Parkinson's disease were significantly restored by the
Hidden
in
Cure Parkinson's
2 years ago
The Constitution of Medical Knowledge (Part 1 of 3)
Patients are often confused by seemingly conflicting findings of studies, or equally good doctors recommending different treatment plans. How are we to decide? Medical science is a process created by a “reality-based community” to help decide such questions. Science isn’t just hypothesis-testing with
Patients are often confused by seemingly conflicting findings of studies, or equally good doctors recommending different treatment plans. How are we to decide? Medical science is a process created by a “reality-based community” to help decide such questions. Science isn’t just hypothesis-testing with
Tall_Allen
in
Prostate Cancer Network
2 years ago
The Constitution of Medical Knowledge (part 1 of 3)
Patients are often confused by seemingly conflicting findings of studies, or equally good doctors recommending different treatment plans. How are we to decide? Medical science is a process created by a “reality-based community” to help decide such questions. Science isn’t just hypothesis-testing with
Patients are often confused by seemingly conflicting findings of studies, or equally good doctors recommending different treatment plans. How are we to decide? Medical science is a process created by a “reality-based community” to help decide such questions. Science isn’t just hypothesis-testing with
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
CRISPR EDIT OF PCSK9 = CURE ... Pt 2
CRISPR EDIT OF PCSK9 = CURE But what if, rather than trying to tackle PCSK9 directly, we just cut it off at the source? If we could introduce mutations to the PCSK9 gene similar to those found in the patients of the UT Southwestern researchers, it should be possible to replicate their resistance
CRISPR EDIT OF PCSK9 = CURE But what if, rather than trying to tackle PCSK9 directly, we just cut it off at the source? If we could introduce mutations to the PCSK9 gene similar to those found in the patients of the UT Southwestern researchers, it should be possible to replicate their resistance
Scout4answers
in
Advanced Prostate Cancer
2 years ago
How has depression affected you and what supports do you need to thrive?
Hello all! My name is Shelby. I'm a grad student pursuing a degree in Mental Health Counseling in New York State. As someone who is looking to enter the mental health field, as well as a family member of someone who has struggled with depression, I'm looking for feedback and insight. Feel free to answer
Hello all! My name is Shelby. I'm a grad student pursuing a degree in Mental Health Counseling in New York State. As someone who is looking to enter the mental health field, as well as a family member of someone who has struggled with depression, I'm looking for feedback and insight. Feel free to answer
Shelby_MHC
in
Anxiety and Depression Support
2 years ago
Insomnia induced by opiods
I have been struggling forever with insomnia caused by taking opiods for RLS. Like many of you here it's worth it because the relief from RLS is so wonderful. I recently added Olanzapine 5mg at night for sleep. I know it's on the naughty list as it tends to increase RLS symptoms. I decided to go ahead
I have been struggling forever with insomnia caused by taking opiods for RLS. Like many of you here it's worth it because the relief from RLS is so wonderful. I recently added Olanzapine 5mg at night for sleep. I know it's on the naughty list as it tends to increase RLS symptoms. I decided to go ahead
ziggypiggy
in
Restless Legs Syndrome
2 years ago
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