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ERLEADA® (apalutamide), First-and-Only Next-Generation Androgen Receptor Inhibitor with Once-Daily, Single-Tablet Option,
The introduction of the 240mg tablet provides the first- and-only option for a once-daily, single-tablet Androgen Receptor Inhibitor (ARI) approved for the treatment of patients with non-metastatic
castration
-resistant prostate cancer (nmCRPC) and for the treatment of patients with metastatic
castration
-sensitive
The introduction of the 240mg tablet provides the first- and-only option for a once-daily, single-tablet Androgen Receptor Inhibitor (ARI) approved for the treatment of patients with non-metastatic
castration
-resistant prostate cancer (nmCRPC) and for the treatment of patients with metastatic
castration
-sensitive
Darryl
Partner
in
Advanced Prostate Cancer
1 year ago
Does anyone have experience with Pasotuxizumab, a BiTE® immune therapy for castration-resistant prostate cancer:
My oncologist told me today that this is the hottest trial going right now and he would consider this for me in the future. I’m curious if anyone has any experience with this treatment and is willing to share. https://pubmed.ncbi.nlm.nih.gov/33172323/
My oncologist told me today that this is the hottest trial going right now and he would consider this for me in the future. I’m curious if anyone has any experience with this treatment and is willing to share. https://pubmed.ncbi.nlm.nih.gov/33172323/
No_stone_unturned
in
Advanced Prostate Cancer
8 months ago
Squalene Monooxygenase
." *** A 2021 Chinese paper [4] reported that: "Our study revealed that SQLE is involved in the progression of
castration
resistance in CRPC through mediating metabolic reprogramming, presenting SQLE as a new target for the treatment of mCRPC." *** I should mention here that: "Inhibitors of squalene
." *** A 2021 Chinese paper [4] reported that: "Our study revealed that SQLE is involved in the progression of
castration
resistance in CRPC through mediating metabolic reprogramming, presenting SQLE as a new target for the treatment of mCRPC." *** I should mention here that: "Inhibitors of squalene
pjoshea13
in
Fight Prostate Cancer
1 year ago
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Docetaxel Extends Enzalutamide Effectiveness
It also shows that triplet therapy may be beneficial in patients who have already progressed to
castration
resistance. We would expect a larger effect if used at the first sign of
castration
resistance. https://www.prostatecancer.news/2022/10/docetaxel-extends-enzalutamide.html
It also shows that triplet therapy may be beneficial in patients who have already progressed to
castration
resistance. We would expect a larger effect if used at the first sign of
castration
resistance. https://www.prostatecancer.news/2022/10/docetaxel-extends-enzalutamide.html
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
BATMAN
"ADT" is a red herring, in that there is no meaningful use of
castration
. I know from experience that testosterone cypionate injected into thigh muscle lingers. It fades away slowly.
"ADT" is a red herring, in that there is no meaningful use of
castration
. I know from experience that testosterone cypionate injected into thigh muscle lingers. It fades away slowly.
pca2004
in
Fight Prostate Cancer
1 year ago
Phase III Study: Saruparib Combo with New Hormonal Agents in mCSPC +/- HRR Mutations: AUA 2024 EvoPAR-Prostate01 Trial
Neeraj Agarwal discussing EvoPAR-Prostate01, a phase III, double-blind, placebo-controlled, 2-cohort, randomized study of saruparib (AZD5305) in combination with new hormonal agents in patients with metastatic
castration
-sensitive prostate cancer (mCSPC) with and without homologous recombination repair
Neeraj Agarwal discussing EvoPAR-Prostate01, a phase III, double-blind, placebo-controlled, 2-cohort, randomized study of saruparib (AZD5305) in combination with new hormonal agents in patients with metastatic
castration
-sensitive prostate cancer (mCSPC) with and without homologous recombination repair
God_Loves_Me
in
Advanced Prostate Cancer
11 days ago
Darolutamide & time to treatment discontinuation in nmCRPC
Comparative real-world (RW) evidence on darolutamide (Daro), enzalutamide (Enza), and apalutamide (Apa) for patients (Pts) with nonmetastatic
castration
-resistant prostate cancer (nmCRPC) in the United States: DEAR.
Comparative real-world (RW) evidence on darolutamide (Daro), enzalutamide (Enza), and apalutamide (Apa) for patients (Pts) with nonmetastatic
castration
-resistant prostate cancer (nmCRPC) in the United States: DEAR.
pca2004
in
Fight Prostate Cancer
1 year ago
What first?: Provenge or Nubeqa?
The patient/author feels confident that doing provenge very early in
castration
resistance, is the better option.
The patient/author feels confident that doing provenge very early in
castration
resistance, is the better option.
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
New results soon (hopefully): A Phase 1 Study of FOR46 in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Not the latest, but some more insight, since results should be on their way https://clinicaltrials.ucsf.edu/trial/NCT03575819 but they are already working on another CD46-targeted alpha therapy based on YS5, a radioimmunoconjugate. https://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02636
Not the latest, but some more insight, since results should be on their way https://clinicaltrials.ucsf.edu/trial/NCT03575819 but they are already working on another CD46-targeted alpha therapy based on YS5, a radioimmunoconjugate. https://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02636
Maxone73
in
Advanced Prostate Cancer
6 months ago
Is ADT beneficial after castration resistance sets in?
Is that because the ADT would be slowing some
castration
sensitive cancer, even though the
castration
resistant cancer is growing separately?
Is that because the ADT would be slowing some
castration
sensitive cancer, even though the
castration
resistant cancer is growing separately?
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Is it useful to get a PSMA-PET scan with low volume cancer, newly castration resistant and PSA below 1?
I was
castration
sensitive at the time of all those scans. I am now
castration
resistant and psa six weeks ago was .33 (up from .14&.20 in August). I don't mind doing the PSMA-PET scan again if it is of value.
I was
castration
sensitive at the time of all those scans. I am now
castration
resistant and psa six weeks ago was .33 (up from .14&.20 in August). I don't mind doing the PSMA-PET scan again if it is of value.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Reduced-Dose Schedule of Cabazitaxel Viable for Seniors With mCRPC - MedPage Today, November 1, 2023
[/i] [i]A reduced-dose schedule of cabazitaxel (Jevtana) plus prophylactic granulocyte colony-stimulating factor (G-CSF) should be offered to older men with metastatic
castration
-resistant prostate cancer (mCRPC), according to results from the phase III randomized CABASTY trial.
[/i] [i]A reduced-dose schedule of cabazitaxel (Jevtana) plus prophylactic granulocyte colony-stimulating factor (G-CSF) should be offered to older men with metastatic
castration
-resistant prostate cancer (mCRPC), according to results from the phase III randomized CABASTY trial.
CaptnMojoe
in
Fight Prostate Cancer
7 months ago
ONCT-534 Earns FDA Fast Track Designation in R/R Metastatic CRPC
ONCT-534 Earns FDA Fast Track Designation in R/R Metastatic CRPC October 27, 2023 Investigators will assess the safety and preliminary anti-tumor activity of ONCT-534 in metastatic
castration
-resistant prostate cancer in the phase 1/2 study ONCT-534-101.
ONCT-534 Earns FDA Fast Track Designation in R/R Metastatic CRPC October 27, 2023 Investigators will assess the safety and preliminary anti-tumor activity of ONCT-534 in metastatic
castration
-resistant prostate cancer in the phase 1/2 study ONCT-534-101.
Scout4answers
in
Advanced Prostate Cancer
7 months ago
Neuroendocrine Prostate cancer (NEPC) questions.
Introduction Neuroendocrine prostate cancer (NEPC) is rare, accounting for only about 0.2–1% of whole prostate cancers.1 On the other hand, it has been reported that 17–40% of the
castration
-resistant prostatic cancers under anti-androgen therapies changed into NEPC.2 The longer anti-androgen therapy
Introduction Neuroendocrine prostate cancer (NEPC) is rare, accounting for only about 0.2–1% of whole prostate cancers.1 On the other hand, it has been reported that 17–40% of the
castration
-resistant prostatic cancers under anti-androgen therapies changed into NEPC.2 The longer anti-androgen therapy
GeorgeGlass
in
Advanced Prostate Cancer
11 days ago
Help: Metastasized Castration Resistant Prostate Cancer!
— Yesterday my current doctor of the 5, given me in 16+ months, told me that I had
castration
-resistant prostate cancer and asked me in my second meeting with him if I had a living will. He told me that I may live a year or two at most.
— Yesterday my current doctor of the 5, given me in 16+ months, told me that I had
castration
-resistant prostate cancer and asked me in my second meeting with him if I had a living will. He told me that I may live a year or two at most.
Yin-Yin
in
Advanced Prostate Cancer
2 years ago
After Zofigo, what next?
I've read about the Eclipse trial (Pluvicto, 177Lu-PSMA-I&T versus Hormone Therapy in Patients with Metastatic
Castration
-Resistant Prostate Cancer) that is available here in Orlando. It looks like he'd qualify 12 weeks post-Zofigo.
I've read about the Eclipse trial (Pluvicto, 177Lu-PSMA-I&T versus Hormone Therapy in Patients with Metastatic
Castration
-Resistant Prostate Cancer) that is available here in Orlando. It looks like he'd qualify 12 weeks post-Zofigo.
Tinuriel
in
Advanced Prostate Cancer
10 months ago
Michael T Schweizer & BAT [Bipolar Androgen Therapy
Resistance develops in part because
castration
-resistant prostate cancer (CRPC) cells adaptively up-regulate AR levels through overexpression, amplification, and expression of ligand-independent variants in response to chronic exposure to a low-testosterone environment."
Resistance develops in part because
castration
-resistant prostate cancer (CRPC) cells adaptively up-regulate AR levels through overexpression, amplification, and expression of ligand-independent variants in response to chronic exposure to a low-testosterone environment."
pca2004
in
Fight Prostate Cancer
1 year ago
Which treatment option best for recurrent oligo?
Since I have BRCA+ 5 BAT 6 BAT + PARP inhibitor Bipolar androgen therapy plus olaparib in men with metastatic
castration
-resistant prostate cancer - PubMed (nih.gov (Anecdotally one member on this forum is on BAT + pulsed Olaparib only taking this three days a month around the T injection, with
Since I have BRCA+ 5 BAT 6 BAT + PARP inhibitor Bipolar androgen therapy plus olaparib in men with metastatic
castration
-resistant prostate cancer - PubMed (nih.gov (Anecdotally one member on this forum is on BAT + pulsed Olaparib only taking this three days a month around the T injection, with
Purple-Bike
in
Advanced Prostate Cancer
3 months ago
PSA fluctuations on docetaxel?
(Note: this is his first time being on chemo as he’s never been on chemotherapy before and he has had
castration
-resistant PC for 11 years, metastasized to the pelvis in 2019. He’ll be on dose #7 of docetaxel as of tomorrow).
(Note: this is his first time being on chemo as he’s never been on chemotherapy before and he has had
castration
-resistant PC for 11 years, metastasized to the pelvis in 2019. He’ll be on dose #7 of docetaxel as of tomorrow).
PHnerd
in
Advanced Prostate Cancer
1 year ago
The Thymus & ADT
Many years ago, I discovered that
castration
could cause the thymus to regenerate. I wondered what that meant for PCa patients. There didn't seem to be any interest in the literature. For those who like sweetbreads (as I do), you will be eating the thymus gland.
Many years ago, I discovered that
castration
could cause the thymus to regenerate. I wondered what that meant for PCa patients. There didn't seem to be any interest in the literature. For those who like sweetbreads (as I do), you will be eating the thymus gland.
pca2004
in
Fight Prostate Cancer
1 year ago
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