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Castration
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Long-term remission of prostate cancer with extensive bone metastases upon immuno- and virotherapy: A case report
In a phase III trial, following vaccination with activated autologous DC, a prolonged overall survival time was demonstrated in patients suffering from
castration
-resistant prostate cancer (4).
In a phase III trial, following vaccination with activated autologous DC, a prolonged overall survival time was demonstrated in patients suffering from
castration
-resistant prostate cancer (4).
JLS1
in
Advanced Prostate Cancer
6 years ago
Recent article about Lutetium 177 treatment in advanced mCRPC by doctors at the Technical University of Munich
Munich, Munich, Germany; Technical University of Munich, Munich, Germany Abstract Disclosures Background: To report our clinical experience with 177Lutetium-labeled prostate-specific membrane antigen-ligand (177Lu-PSMA-I&T) for systemic radioligand therapy in 100 consecutive patients with metastatic
castration
-resistant
Munich, Munich, Germany; Technical University of Munich, Munich, Germany Abstract Disclosures Background: To report our clinical experience with 177Lutetium-labeled prostate-specific membrane antigen-ligand (177Lu-PSMA-I&T) for systemic radioligand therapy in 100 consecutive patients with metastatic
castration
-resistant
Hidden
in
Advanced Prostate Cancer
6 years ago
CRPC & Avodart [Dutasteride].
Abstract It has previously been demonstrated that the intratumoral generation of the potent androgen dihydrotestosterone (DHT), contributes critically to the progression of prostate cancer and its
castration
-resistant form,
castration
-resistant prostate cancer (CRPC).
Abstract It has previously been demonstrated that the intratumoral generation of the potent androgen dihydrotestosterone (DHT), contributes critically to the progression of prostate cancer and its
castration
-resistant form,
castration
-resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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Jevtana [Cabazitaxel] & Androgen Status.
Thereby, maintaining its role even in
castration
resistant prostate cancer (CRPC).
Thereby, maintaining its role even in
castration
resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Non-PCa Prescription Drugs: Thalidomide / Lenalidomide (Revlimid)
An anecdotal German case (2012) [6]: "Long-term disease stabilization in a patient with
castration
-resistant metastatic prostate cancer by the addition of lenalidomide to low-dose dexamethasone and celecoxib."
An anecdotal German case (2012) [6]: "Long-term disease stabilization in a patient with
castration
-resistant metastatic prostate cancer by the addition of lenalidomide to low-dose dexamethasone and celecoxib."
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (Xofigo - Radium-223 retreatment)
population, led to minimal hematologic toxicity, and provided continued disease control in bone at 2-year follow-up." [1] -Patrick [1] 178 Poster Session (Board #H18), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM Radium-223 retreatment in an international, open-label, phase 1/2 study in patients with
castration
-resistant
population, led to minimal hematologic toxicity, and provided continued disease control in bone at 2-year follow-up." [1] -Patrick [1] 178 Poster Session (Board #H18), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM Radium-223 retreatment in an international, open-label, phase 1/2 study in patients with
castration
-resistant
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Bipolar Androgen Therapy in Men With Metastatic Castration-Resistant Prostate Cancer After Progression on Enzalutamide
http://www.practiceupdate.com/content/bipolar-androgen-therapy-in-men-with-metastatic-
castration
-resistant-prostate-cancer-after-progression-on-enzalutamide/62093/61/11/1
http://www.practiceupdate.com/content/bipolar-androgen-therapy-in-men-with-metastatic-
castration
-resistant-prostate-cancer-after-progression-on-enzalutamide/62093/61/11/1
snoraste
in
Advanced Prostate Cancer
6 years ago
Folate & PCa recurrence in the CWR22 model.
KEYWORDS: androgen withdrawal;
castration
recurrent prostate cancer; folate; one-carbon metabolism; polyamine metabolism PMID: 29262598 PMCID: PMC5732764 DOI: 10.18632/oncotarget.21911 [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094800/
KEYWORDS: androgen withdrawal;
castration
recurrent prostate cancer; folate; one-carbon metabolism; polyamine metabolism PMID: 29262598 PMCID: PMC5732764 DOI: 10.18632/oncotarget.21911 [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094800/
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Low testosterone / PSA failure / risk of death.
i.e. partial
castration
. None of the studies published in the past 13 years have changed the view that it unsafe to be at the high end of hypogonadal, or the very low end of "normal".
i.e. partial
castration
. None of the studies published in the past 13 years have changed the view that it unsafe to be at the high end of hypogonadal, or the very low end of "normal".
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium [PROSPER].
/GU18-Prostate-Cancer-Localized-Disease.pdf -Patrick 3 Oral Abstract Session, Thu, 1:00 PM-2:30 PM and Poster Session (Board #A4), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM PROSPER: A phase 3, randomized, double-blind, placebo (PBO)-controlled study of enzalutamide (ENZA) in men with nonmetastatic
castration
-resistant
/GU18-Prostate-Cancer-Localized-Disease.pdf -Patrick 3 Oral Abstract Session, Thu, 1:00 PM-2:30 PM and Poster Session (Board #A4), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM PROSPER: A phase 3, randomized, double-blind, placebo (PBO)-controlled study of enzalutamide (ENZA) in men with nonmetastatic
castration
-resistant
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (ARV7/AR ratio and neutrophil-to-lymphocyte ratio (NLR) as predictors of docetaxel benefit)
-Patrick 254 Poster Session (Board #M8), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM ARV7/AR ratio and neutrophil-to-lymphocyte ratio (NLR) as predictors of docetaxel benefit in metastatic
castration
-resistant prostate cancer patients (mCRPC).
-Patrick 254 Poster Session (Board #M8), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM ARV7/AR ratio and neutrophil-to-lymphocyte ratio (NLR) as predictors of docetaxel benefit in metastatic
castration
-resistant prostate cancer patients (mCRPC).
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ED, LIBIDO, PUMPS and PILLS
Testicles shrunk, chemical
castration
. I thought Sex was now in the past for me. But I missed it. A lot. I didn't even think about sex for weeks. I am an experimenter by nature so I found a way to get some enjoyment back. I found that my libido was reignited by porn.
Testicles shrunk, chemical
castration
. I thought Sex was now in the past for me. But I missed it. A lot. I didn't even think about sex for weeks. I am an experimenter by nature so I found a way to get some enjoyment back. I found that my libido was reignited by porn.
steinmother
in
Prostate Cancer Network
6 years ago
thoughts from a newby
Maybe a dropdown menu to help beginners, something like: Abbreviations etc Clinical name first (abiraterone), brand name second (Zytiga) varies by country PCa prostate cancer ADT androgen deprivation therapy mCRPC metastatic
castration
-resistant Prostate Cancer mets metastases bicalutamide
Maybe a dropdown menu to help beginners, something like: Abbreviations etc Clinical name first (abiraterone), brand name second (Zytiga) varies by country PCa prostate cancer ADT androgen deprivation therapy mCRPC metastatic
castration
-resistant Prostate Cancer mets metastases bicalutamide
rpol
in
Advanced Prostate Cancer
6 years ago
"Targeting NF-kappa B Signaling by Artesunate Restores Sensitivity of Castrate-Resistant Prostate Cancer Cells to Antiandrogens."
However, the disease eventually progresses and develops resistance to ADT in majority of the patients, leading to the emergence of metastatic
castration
-resistant prostate cancer (mCRPC).
However, the disease eventually progresses and develops resistance to ADT in majority of the patients, leading to the emergence of metastatic
castration
-resistant prostate cancer (mCRPC).
JLS1
in
Advanced Prostate Cancer
6 years ago
How Useful is the Circulating Tumor Cell [CTC] count?
"Purpose Measures of response that are clinically meaningful and occur early are an unmet need in metastatic
castration
-resistant prostate cancer clinical research and practice.
"Purpose Measures of response that are clinically meaningful and occur early are an unmet need in metastatic
castration
-resistant prostate cancer clinical research and practice.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Estrogen and Androgen Blockade for Advanced PCa.
Abstract Androgen deprivation therapy (ADT) has been widely prescribed for patients with advanced prostate cancer (PC) to control key signaling pathways via androgen receptor (AR) and AR-collaborative transcriptional factors; however, PC gradually acquires a lethal phenotype and results in
castration
-resistant
Abstract Androgen deprivation therapy (ADT) has been widely prescribed for patients with advanced prostate cancer (PC) to control key signaling pathways via androgen receptor (AR) and AR-collaborative transcriptional factors; however, PC gradually acquires a lethal phenotype and results in
castration
-resistant
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide.
Further studies with BAT are needed to define the potential clinical role for BAT in the management of metastatic
castration
-resistant prostate cancer and the optimal strategy for sequencing between androgen and antiandrogen therapies in metastatic
castration
-resistant prostate cancer to maximise therapeutic
Further studies with BAT are needed to define the potential clinical role for BAT in the management of metastatic
castration
-resistant prostate cancer and the optimal strategy for sequencing between androgen and antiandrogen therapies in metastatic
castration
-resistant prostate cancer to maximise therapeutic
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Supraphysiologic Testosterone Therapy for PCa. BAT.
In this regard
castration
resistant VCaP cells treated with sequentially higher T doses had less significant apoptotic responses to androgen withdrawal than those seen in VCaP cells exposed to a single high T “boost”." ...
In this regard
castration
resistant VCaP cells treated with sequentially higher T doses had less significant apoptotic responses to androgen withdrawal than those seen in VCaP cells exposed to a single high T “boost”." ...
pjoshea13
in
Advanced Prostate Cancer
6 years ago
The War on Cancer, & Stem-like Cancer Cells.
The big success stories of recent years - Zytiga & Xtandi - follow in the Huggins tradition by targeting the androgen receptor [AR], either directly (as with Casodex, & now Xtandi) or by starving AR of hormones (as with
castration
, DES, Lupron, & now Zytiga). Alas, PCa progenitor cells lack AR.
The big success stories of recent years - Zytiga & Xtandi - follow in the Huggins tradition by targeting the androgen receptor [AR], either directly (as with Casodex, & now Xtandi) or by starving AR of hormones (as with
castration
, DES, Lupron, & now Zytiga). Alas, PCa progenitor cells lack AR.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Integrating evolutionary dynamics into treatment of mCRPC.
Castration
continues well into the off-phase, according to Freedland. In addition, the first on-phase is often a year, by which time only "bad" cells are present. If T were to be supplemented in the off phase-of IADT, after a much shorter on-phase, we would expect to see some reset activity.
Castration
continues well into the off-phase, according to Freedland. In addition, the first on-phase is often a year, by which time only "bad" cells are present. If T were to be supplemented in the off phase-of IADT, after a much shorter on-phase, we would expect to see some reset activity.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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