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prednisone etc
My hot flashes are somewhat under control but the other symptoms of
castration
seem to be getting worse. Today I had such muscle weakness that i had a hard time walking. Muscles did not cooperate. I hope this i just from the lack of prednisone. Is retaining fluid in feet normal?
My hot flashes are somewhat under control but the other symptoms of
castration
seem to be getting worse. Today I had such muscle weakness that i had a hard time walking. Muscles did not cooperate. I hope this i just from the lack of prednisone. Is retaining fluid in feet normal?
spencoid2
in
Advanced Prostate Cancer
3 years ago
Bipolar Androgen Therapy (BAT) update (with olaparib)
repair defects • 3 of 6 90+% progressors had DNA damage repair defects • 5 patients had serious (grade ≥ 3) toxicity, including one death https://www.urotoday.com/conference-highlights/esmo-2021/esmo-2021-prostate-cancer/132121-esmo-2021-bipolar-androgen-therapy-bat-plus-olaparib-in-men-with-metastatic-
castration
-resistant-prostate-cancer.html
repair defects • 3 of 6 90+% progressors had DNA damage repair defects • 5 patients had serious (grade ≥ 3) toxicity, including one death https://www.urotoday.com/conference-highlights/esmo-2021/esmo-2021-prostate-cancer/132121-esmo-2021-bipolar-androgen-therapy-bat-plus-olaparib-in-men-with-metastatic-
castration
-resistant-prostate-cancer.html
Tall_Allen
in
Advanced Prostate Cancer
3 years ago
The Metabolic Syndrome [MetS] & PCa
." *** {This post was prompted by the recent post from noahware: his title - "
Statins: new study regarding time to CRPC
" study title - "
Metabolic syndrome and its pharmacologic treatment are associated with the time to
-resistant prostate cancer" "[u][i]Importantly, in men with
." *** {This post was prompted by the recent post from noahware: his title - "
Statins: new study regarding time to CRPC
" study title - "
Metabolic syndrome and its pharmacologic treatment are associated with the time to
-resistant prostate cancer" "[u][i]Importantly, in men with
pjoshea13
in
Advanced Prostate Cancer
2 years ago
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Apalutamide plus abiraterone acetate and prednisone versus placebo plus abiraterone and prednisone in metastatic, CRPC
"The majority of patients with metastatic
castration
-resistant prostate cancer (mCRPC) will have disease progression of a uniformly fatal disease. mCRPC is driven by both activated androgen receptors and elevated intratumoural androgens; however, the current standard of care is therapy that targets a
"The majority of patients with metastatic
castration
-resistant prostate cancer (mCRPC) will have disease progression of a uniformly fatal disease. mCRPC is driven by both activated androgen receptors and elevated intratumoural androgens; however, the current standard of care is therapy that targets a
pjoshea13
in
Advanced Prostate Cancer
3 years ago
The Vision Trial - Offering Real Hope for the Heavily Treated MCRPC Patient
Key findings showed a significant improvement in overall survival with the addition of targeted radioligand therapy LuPSMA) to the standard of care in patients with progressive PSMA positive metastatic
castration
resistant cancer.
Key findings showed a significant improvement in overall survival with the addition of targeted radioligand therapy LuPSMA) to the standard of care in patients with progressive PSMA positive metastatic
castration
resistant cancer.
marnieg46
in
Fight Prostate Cancer
3 years ago
obesity paradox?—improved survival outcomes in mCRPC patients with a high body mass index (BMI)
Wagaskar, MBBS, highlights a study presented at the 2021 European Association of Urology Congress which reported evidence of the obesity paradox in patients with metastatic
castration
-resistant prostate cancer (mCRPC). https://www.urologytimes.com/view/dr-wagaskar-explains-the-obesity-paradox-in-prostate-cancer
Wagaskar, MBBS, highlights a study presented at the 2021 European Association of Urology Congress which reported evidence of the obesity paradox in patients with metastatic
castration
-resistant prostate cancer (mCRPC). https://www.urologytimes.com/view/dr-wagaskar-explains-the-obesity-paradox-in-prostate-cancer
JRPnSD
in
Advanced Prostate Cancer
3 years ago
BAT, SAT & SARMs
SAT may counter adaptive cellular mechanisms that contribute to a
castration
-resistant phenotype.
SAT may counter adaptive cellular mechanisms that contribute to a
castration
-resistant phenotype.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Docetaxel or Abiraterone in Metastatic Castration-Sensitive Prostate Cancer [mCSPC]
PMID: 34026638 PMCID: PMC8138065 DOI: 10.3389/fonc.2021.658331 Abstract Background: Both Docetaxel (DOC) and Abiraterone (ABI) improve the survival of men with metastatic,
castration
sensitive prostate cancer (mCSPC).
PMID: 34026638 PMCID: PMC8138065 DOI: 10.3389/fonc.2021.658331 Abstract Background: Both Docetaxel (DOC) and Abiraterone (ABI) improve the survival of men with metastatic,
castration
sensitive prostate cancer (mCSPC).
pjoshea13
in
Advanced Prostate Cancer
3 years ago
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
Androgen receptor (AR) antagonists play a pivotal role in the treatment of metastatic
castration
-resistant prostate cancer (mCRPC), but they still face the problem of drug resistance.
Androgen receptor (AR) antagonists play a pivotal role in the treatment of metastatic
castration
-resistant prostate cancer (mCRPC), but they still face the problem of drug resistance.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Metformin Possibly Beneficial in Advanced Prostate Cancer
https://www.endocrinologyadvisor.com/home/topics/diabetes/metformin-added-to-adt-delays-development-of-
castration
-resistant-prostate-cancer/ https://www.sciencedirect.com/science/article/abs/pii/S1078143921002283?dgcid=raven_sd_aip_email
https://www.endocrinologyadvisor.com/home/topics/diabetes/metformin-added-to-adt-delays-development-of-
castration
-resistant-prostate-cancer/ https://www.sciencedirect.com/science/article/abs/pii/S1078143921002283?dgcid=raven_sd_aip_email
dorke
in
Advanced Prostate Cancer
3 years ago
Darolutamide vs. Apalutamide vs. Enzalutamide
Consideration of these adverse events is important in clinical decision-making and treatment selection in nonmetastatic
castration
-resistant prostate cancer.
Consideration of these adverse events is important in clinical decision-making and treatment selection in nonmetastatic
castration
-resistant prostate cancer.
MateoBeach
in
Advanced Prostate Cancer
3 years ago
Abiraterone+docetaxel+ADT for newly diagnosed metastatic men beats docetaxel+ADT (or abiraterone+ADT)
Time to
castration
resistance increased by 1.7 yrs (from 1.5 to 3.2 yrs). The full results will tell us how much the prostate radiation adds, and the effect on overall survival. The analysis by metastatic burden will be important too.
Time to
castration
resistance increased by 1.7 yrs (from 1.5 to 3.2 yrs). The full results will tell us how much the prostate radiation adds, and the effect on overall survival. The analysis by metastatic burden will be important too.
Tall_Allen
in
Advanced Prostate Cancer
3 years ago
Apalutamide in Patients With Metastatic Castration-Sensitive Prostate Cancer: Final Survival Analysis of the Randomized, Double-Blind, Phase
Apalutamide plus ADT delayed second progression-free survival and
castration
resistance (P < .0001 for both). Health-related quality of life, per total Functional Assessment of Cancer Therapy-Prostate, in both groups was maintained through the study. Safety was consistent with previous reports."
Apalutamide plus ADT delayed second progression-free survival and
castration
resistance (P < .0001 for both). Health-related quality of life, per total Functional Assessment of Cancer Therapy-Prostate, in both groups was maintained through the study. Safety was consistent with previous reports."
snoraste
in
Advanced Prostate Cancer
3 years ago
11-Ketotestosterone [11KT] (& 11-Ketodihydrotestosterone [11KDHT])
From a 2020 U.S. study [3]: "In CRPC patients, administration of {Abi & medical
castration
} lowered all four 11-oxygenated androgens to below the lower limits of quantitation ..." *** ... but 11KT remains of interest to those whose only AR-axis targeted therapy is
castration
.
From a 2020 U.S. study [3]: "In CRPC patients, administration of {Abi & medical
castration
} lowered all four 11-oxygenated androgens to below the lower limits of quantitation ..." *** ... but 11KT remains of interest to those whose only AR-axis targeted therapy is
castration
.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Considering orchiectomy?
I’m considering an orchiectomy instead of continuing expensive medical
castration
treatments. Any advice/experiences with one vs the other? I’m 71 and Gleason 7/8.
I’m considering an orchiectomy instead of continuing expensive medical
castration
treatments. Any advice/experiences with one vs the other? I’m 71 and Gleason 7/8.
Woodman33
in
Advanced Prostate Cancer
3 years ago
Apalutamide aka Erleada = Good Stuff!
https://www.urotoday.com/conference-highlights/asco-2021/asco-2021-prostate-cancer/129935-asco-2021-health-related-quality-of-life-and-patient-reported-outcomes-at-final-analysis-of-the-titan-study-in-patients-with-metastatic-
castration
-sensitive-prostate-cancer.html?
https://www.urotoday.com/conference-highlights/asco-2021/asco-2021-prostate-cancer/129935-asco-2021-health-related-quality-of-life-and-patient-reported-outcomes-at-final-analysis-of-the-titan-study-in-patients-with-metastatic-
castration
-sensitive-prostate-cancer.html?
Hidden
in
Advanced Prostate Cancer
3 years ago
PCa-specific Survival after Radical Prostatectomy Is Improved by Metformin but not other Antidiabetic Drugs
Poorly controlled diabetes increases the risk of metastases and
castration
-resistant prostate cancer in men undergoing radical prostatectomy: results from the SEARCH database. Cancer. 2019;125:2861–2867. - PMC - PubMed Murtola T.J., Sälli S.M., Talala K., Taari K., Tammela T.J., Auvinen A.
Poorly controlled diabetes increases the risk of metastases and
castration
-resistant prostate cancer in men undergoing radical prostatectomy: results from the SEARCH database. Cancer. 2019;125:2861–2867. - PMC - PubMed Murtola T.J., Sälli S.M., Talala K., Taari K., Tammela T.J., Auvinen A.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Update on lutetium treatment at Hopkins
177Lu-PSMA-R2 in Patients With PSMA Positive Progressive, Metastatic,
Castration
Resistant Prostate Cancer I have received all three treatments as of May 20. They were six weeks apart. My initial PSA was 90.
177Lu-PSMA-R2 in Patients With PSMA Positive Progressive, Metastatic,
Castration
Resistant Prostate Cancer I have received all three treatments as of May 20. They were six weeks apart. My initial PSA was 90.
wpopomaronis
in
Advanced Prostate Cancer
3 years ago
Neutrophil:Lymphocyte Ratio [NLR] in patients with mCRPC treated with Cabazitaxel v. Abiraterone or Enzalutamide in the CARD study
Keywords: abiraterone; cabazitaxel; enzalutamide; metastatic
castration
-resistant prostate cancer; neutrophil-to-lymphocyte ratio; prognostic factor. Copyright © 2021 The Authors. Published by Elsevier Ltd..
Keywords: abiraterone; cabazitaxel; enzalutamide; metastatic
castration
-resistant prostate cancer; neutrophil-to-lymphocyte ratio; prognostic factor. Copyright © 2021 The Authors. Published by Elsevier Ltd..
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Off label use of Mekinist (Trametinib)
MEK-ERK signaling is a therapeutic target in metastatic
resistant prostate cancer Prostate cancer and prostatic diseases 22(4), 531-538, 2019 "ERK1 is the immediate downstream target of MEK1/2, which is druggable with trametinib, an approved therapeutic for melanoma."
MEK-ERK signaling is a therapeutic target in metastatic
resistant prostate cancer Prostate cancer and prostatic diseases 22(4), 531-538, 2019 "ERK1 is the immediate downstream target of MEK1/2, which is druggable with trametinib, an approved therapeutic for melanoma."
Graham49
in
Advanced Prostate Cancer
3 years ago
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