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Early Results from Transdermal Estrogen PATCH trial - 2
So, TDE is more effective at
castration
than Lupron
in this study.
The lower chart shows the level of estradiol (picomol/L) after 1 month of treatment. The Lupron level is about 60, while the high-dose level is much higher, about 840 (pico mol/L) (i.e., supra-physiologic).
So, TDE is more effective at
castration
than Lupron
in this study.
The lower chart shows the level of estradiol (picomol/L) after 1 month of treatment. The Lupron level is about 60, while the high-dose level is much higher, about 840 (pico mol/L) (i.e., supra-physiologic).
janebob99
in
Advanced Prostate Cancer
2 months ago
Becoming mCRPC despite falling PSA
He accepted this during the meeting, but afterwards didn't really unterstand why he was seen as
castration
resistant now despite the ever decreasing PSA. Could the doctor classify him as
castration
resistant just because of the result of the MRI?
He accepted this during the meeting, but afterwards didn't really unterstand why he was seen as
castration
resistant now despite the ever decreasing PSA. Could the doctor classify him as
castration
resistant just because of the result of the MRI?
kennycool
in
Advanced Prostate Cancer
4 months ago
Swollen cord-stump after castration?
It was often swollen over some days sporadically in the first year after
castration
. Than it decreased with the time. Now - shortly after a TURP at 13. Oktober - the stump got swollen again. I believe or feel until 1 cm diameter.
It was often swollen over some days sporadically in the first year after
castration
. Than it decreased with the time. Now - shortly after a TURP at 13. Oktober - the stump got swollen again. I believe or feel until 1 cm diameter.
hanseunuch
in
Advanced Prostate Cancer
5 months ago
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OS versus Testosterone Nadir - 5
(Ref: 2024) The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
(Ref: 2024) The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
janebob99
in
Advanced Prostate Cancer
2 months ago
OS versus Testosterone Nadir - 4
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
janebob99
in
Advanced Prostate Cancer
2 months ago
Arx517 updates about the trial for metastatic castration resistant prostate cancer
patients in Cohort 9 experienced rapid PSA reduction at three weeks post-treatment following the first ARX517 dose” https://www.biospace.com/article/releases/ambrx-provides-update-on-apex-01-an-on-going-phase-1-2-dose-escalation-study-evaluating-arx517-a-proprietary-psma-targeting-adc-in-metastatic-
castration
-resistant-prostate-cancer
patients in Cohort 9 experienced rapid PSA reduction at three weeks post-treatment following the first ARX517 dose” https://www.biospace.com/article/releases/ambrx-provides-update-on-apex-01-an-on-going-phase-1-2-dose-escalation-study-evaluating-arx517-a-proprietary-psma-targeting-adc-in-metastatic-
castration
-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
5 months ago
Medical OR chemical castration
My question is should I get medical
castration
to reduce the side effect of extended ADT injections or continue with the ADT. Does medical have less side effects? I understand that I may also need a penal implant.
My question is should I get medical
castration
to reduce the side effect of extended ADT injections or continue with the ADT. Does medical have less side effects? I understand that I may also need a penal implant.
Stevegr
in
Advanced Prostate Cancer
6 months ago
Doubling Times and PSA acceleration - Part II
This can be accomplished by chemical
castration
by either Lupron-based ADT or transdermal estrogen (TDE) therapy (or both). Chemical
castration
with transdermal estrogen (patch or gel) eliminates most of the bad side effects associated with Lupron ADT.
This can be accomplished by chemical
castration
by either Lupron-based ADT or transdermal estrogen (TDE) therapy (or both). Chemical
castration
with transdermal estrogen (patch or gel) eliminates most of the bad side effects associated with Lupron ADT.
janebob99
in
Prostate Cancer Network
2 months ago
combining standard PCA care with alternative care
If you are
castration
resistant why not give it a try? Termination or treatment, your choice.
If you are
castration
resistant why not give it a try? Termination or treatment, your choice.
agnut
in
Fight Prostate Cancer
5 months ago
Surgical Castration ?
I have been on Eligard for two months. Prior to starting ADT my Triglycerides were 100 (May 2023). After only two months of Eligard they are thru the roof (495). Since I have metastatic PC they tell me that I will be on ADT for life. I am considering surgical orchiectomy since there are fewer metabolic
I have been on Eligard for two months. Prior to starting ADT my Triglycerides were 100 (May 2023). After only two months of Eligard they are thru the roof (495). Since I have metastatic PC they tell me that I will be on ADT for life. I am considering surgical orchiectomy since there are fewer metabolic
Bigmaristuff
in
Advanced Prostate Cancer
8 months ago
need some guidance, feeling desperate..
My husband has advanced, Stage IV
castration
resistant prostate cancer. When he was diagnosed in May 2022 his PSA was 4700, he has widespread bone metastases. He stopped responding to Docetaxel, Pluvicto and is now not responding to Cabazitaxel, his PSA is now over 700.
My husband has advanced, Stage IV
castration
resistant prostate cancer. When he was diagnosed in May 2022 his PSA was 4700, he has widespread bone metastases. He stopped responding to Docetaxel, Pluvicto and is now not responding to Cabazitaxel, his PSA is now over 700.
Kiki27
in
Advanced Prostate Cancer
4 months ago
Could BAT be our last chance?
My husband (on Lupron,
castration
resistant and tried every treatment) checked into the hospital 10 days ago for intense bone pain that requires heavy morphine. He has weakened bone marrow with low platelets and low red blood cells. He's getting palliative radiation for pain in a few places.
My husband (on Lupron,
castration
resistant and tried every treatment) checked into the hospital 10 days ago for intense bone pain that requires heavy morphine. He has weakened bone marrow with low platelets and low red blood cells. He's getting palliative radiation for pain in a few places.
Chris_Ali
in
Advanced Prostate Cancer
1 month ago
EPI-7386 now called Masofaniten - Phase II Starting in US and Canada
Hopefully this will get around some mechanisms of
castration
resistance, since hormonal agents (Enza, Appa, Daro) target the AR LBD (Ligand Binding Domain) and eventually AR mutations bypass the LBD for activation rendering the hormonal agents ineffective. -------- Another Drug to watch that targets
Hopefully this will get around some mechanisms of
castration
resistance, since hormonal agents (Enza, Appa, Daro) target the AR LBD (Ligand Binding Domain) and eventually AR mutations bypass the LBD for activation rendering the hormonal agents ineffective. -------- Another Drug to watch that targets
skiingfiend
in
Advanced Prostate Cancer
7 months ago
Lupron Question.
I have been thinking about surgical
castration
but before something so drastic I have decided to ask my MO if he would agree to monitor testosterone and stop Lupron all together to see where the testosterone goes.
I have been thinking about surgical
castration
but before something so drastic I have decided to ask my MO if he would agree to monitor testosterone and stop Lupron all together to see where the testosterone goes.
Professorgary
in
Advanced Prostate Cancer
4 months ago
How many estrogen patches to use?
Some men may need to titrate (adjust) the number of patches in order to reach a desired amount of
castration
(for example, T < 10 ng/dL) Low-dose estrogen (2 patches per week) can help manage hot flashes in men on ADT, while high-dose estrogen (4 patches, changed twice a week) can be used to chemically
Some men may need to titrate (adjust) the number of patches in order to reach a desired amount of
castration
(for example, T < 10 ng/dL) Low-dose estrogen (2 patches per week) can help manage hot flashes in men on ADT, while high-dose estrogen (4 patches, changed twice a week) can be used to chemically
janebob99
in
Prostate Cancer Network
2 months ago
Where do I go for alternative to continuous ADT?
I want to an alternative to continuous ADT, whether its IADT, BAT or something else, in hopes of preventing
castration
resistance. I live on the East Coast of U.S. I exercise a lot each day and have cleaned up my diet.
I want to an alternative to continuous ADT, whether its IADT, BAT or something else, in hopes of preventing
castration
resistance. I live on the East Coast of U.S. I exercise a lot each day and have cleaned up my diet.
Forest1160
in
Fight Prostate Cancer
6 months ago
The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
Maxone73
in
Fight Prostate Cancer
3 months ago
How many estrogen patches should I use?
Some men may need to titrate (adjust) the number of patches in order to reach a desired amount of
castration
(for example, T < 10 ng/dL). I hope to be able to generate a similar plot for men who use estrogen gel, although that is less standardized.
Some men may need to titrate (adjust) the number of patches in order to reach a desired amount of
castration
(for example, T < 10 ng/dL). I hope to be able to generate a similar plot for men who use estrogen gel, although that is less standardized.
janebob99
in
Advanced Prostate Cancer
2 months ago
My MO suspects that I am non-metastatic, castration resistant but will not approve any treatment until metastases develop.
I am not sure I am
castration
resistant because my T has gone up but is still considered low by him. I am really conflicted right now and I do not know what I should do??
I am not sure I am
castration
resistant because my T has gone up but is still considered low by him. I am really conflicted right now and I do not know what I should do??
Balsam01
in
Advanced Prostate Cancer
4 months ago
What should I expect at the end?
My dad 77 year old had been battling
castration
resistant prostate cancer for many years.
My dad 77 year old had been battling
castration
resistant prostate cancer for many years.
Pechey
in
Advanced Prostate Cancer
3 months ago
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