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Statin Use Is Associated with Better Prognosis of Patients with Prostate Cancer after Definite Therapies:
Castration
therapy continues to be a "popular" PCa therapy. Early resistance continues to be common, even with add-on androgen-axis drugs. One form of resistance involves the generation of androgens from cholesterol - within the cancer cell. Statin use is insurance against that.
Castration
therapy continues to be a "popular" PCa therapy. Early resistance continues to be common, even with add-on androgen-axis drugs. One form of resistance involves the generation of androgens from cholesterol - within the cancer cell. Statin use is insurance against that.
pjoshea13
in
Fight Prostate Cancer
1 year ago
More from PubMed
Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic
castration
-sensitive prostate cancer.
Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic
castration
-sensitive prostate cancer.
Magnus1964
in
Advanced Prostate Cancer
11 months ago
Cabergoline/ Dostinex/ Casodex - Prolactin suppression to remain Hormone sensitive
This leads to the development of “androgen-independent” malignancy; which is the status of advanced prostate cancer (
castration
resistant prostate cancer; CRPC). Androgen-independent advanced prostate cancer results in patient death generally in 2-5 years.
This leads to the development of “androgen-independent” malignancy; which is the status of advanced prostate cancer (
castration
resistant prostate cancer; CRPC). Androgen-independent advanced prostate cancer results in patient death generally in 2-5 years.
Scout4answers
in
Advanced Prostate Cancer
1 year ago
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A List for Newly Diagnosed that My Wife did in 2022 please add to list if anything is missed or wrong or needs updating. TIA
Bat Therapy BIPOLAR ANDROGEN THERAPY (BAT): A Treatment Option for Metastatic
Castration
-Resistant Prostate Cancer (mCRPC).
Bat Therapy BIPOLAR ANDROGEN THERAPY (BAT): A Treatment Option for Metastatic
Castration
-Resistant Prostate Cancer (mCRPC).
Shorehousejam
in
Advanced Prostate Cancer
7 months ago
How can I increase blood platelets?
This coincides with
castration
resistance setting in. Are there certain supplements that can raise the platelet count? What is the likely cause of the lower platelet count, which is normally about 130-140k for me. My recent tests have shown the count to be 100, 90, 86 and 110.
This coincides with
castration
resistance setting in. Are there certain supplements that can raise the platelet count? What is the likely cause of the lower platelet count, which is normally about 130-140k for me. My recent tests have shown the count to be 100, 90, 86 and 110.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Efficacy and safety of BAT in CRPC following Abi or Enza resistance: A systematic review
"Bipolar androgen therapy (BAT) is a new endocrinologic treatment for
castration
-resistant prostate cancer (CRPC) that can restore some patients' sensitivity to drugs such as abiraterone (Abi) and enzalutamide (Enz). ...
"Bipolar androgen therapy (BAT) is a new endocrinologic treatment for
castration
-resistant prostate cancer (CRPC) that can restore some patients' sensitivity to drugs such as abiraterone (Abi) and enzalutamide (Enz). ...
pjoshea13
in
Fight Prostate Cancer
1 year ago
Genetics - Some answers but not all
ERG induces taxane resistance in
castration
-resistant prostate cancer. Nat. Commun. 2014;5:5548. doi: 10.1038/ncomms6548. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
ERG induces taxane resistance in
castration
-resistant prostate cancer. Nat. Commun. 2014;5:5548. doi: 10.1038/ncomms6548. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
spw1
in
Advanced Prostate Cancer
1 year ago
Cytoreductive Prostatectomy & Oligometastatic PCa.
. “… time to {
castration
-resistant prostate cancer} was statistically significant in the {cytoreductive prostatectomy} group in all analyses ({randomized controlled trial}; HR=0.44 …) ({non-randomized controlled trials}; HR=0.64 …). “… {cancer-specific-survival} was not statistically different
. “… time to {
castration
-resistant prostate cancer} was statistically significant in the {cytoreductive prostatectomy} group in all analyses ({randomized controlled trial}; HR=0.44 …) ({non-randomized controlled trials}; HR=0.64 …). “… {cancer-specific-survival} was not statistically different
pca2004
in
Fight Prostate Cancer
11 months ago
PTEN loss is not a determinant of time to castration-resistance following androgen-deprivation therapy in prostate cancer
Keywords: ADT; CRPC; Jordan; PTEN;
castration
resistance; prostate cancer. ©2023 JOURNAL of MEDICINE and LIFE.
Keywords: ADT; CRPC; Jordan; PTEN;
castration
resistance; prostate cancer. ©2023 JOURNAL of MEDICINE and LIFE.
Magnus1964
in
Advanced Prostate Cancer
11 months ago
Xtandi (enzalutamide) alone is superior to ADT alone at preventing metastases in "high-risk" recurrent men
Also improved time to PSA progression/
castration
-resistance and time to chemo. No data yet on overall survival. Men achieving PSA≤ 0.2 ng/ml were given a vacation from therapy until PSA rose again. No QOL data yet.
Also improved time to PSA progression/
castration
-resistance and time to chemo. No data yet on overall survival. Men achieving PSA≤ 0.2 ng/ml were given a vacation from therapy until PSA rose again. No QOL data yet.
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
actual castration instead of ADT
I’m just throwing this out for discussion. I’m 62 in good over shape and recently started Lupron and Zytiga. I am told I will be on these or some form of ADT for the rest of my life. Since the goal is to eliminate testosterone wouldn’t it make sense to remove the source of it? By doing so one could
I’m just throwing this out for discussion. I’m 62 in good over shape and recently started Lupron and Zytiga. I am told I will be on these or some form of ADT for the rest of my life. Since the goal is to eliminate testosterone wouldn’t it make sense to remove the source of it? By doing so one could
OldGuysRule
in
Advanced Prostate Cancer
2 years ago
Actual duration of Lupron Depot 22.5 mg/12 weeks X 2.
Testoterone was below ''
Level'' from July 29th 2020 to March 10th 2021.
My PSA went from
[u]
0.18μg/L
[/u]
, July 29th 2020 down to 0.03μg/L on September 07 2022
Testoterone was below ''
Level'' from July 29th 2020 to March 10th 2021.
My PSA went from
[u]
0.18μg/L
[/u]
, July 29th 2020 down to 0.03μg/L on September 07 2022
doc1947g
in
Advanced Prostate Cancer
2 years ago
Advanced PC with a 90 years old
When he becomes
castration
resistant in the future, I'm afraid he won't have many options because of his age and health condition. With
castration
resistance, is ADT and another AR inhibitor or CYP17 inhibitor still a treatment option for him?
When he becomes
castration
resistant in the future, I'm afraid he won't have many options because of his age and health condition. With
castration
resistance, is ADT and another AR inhibitor or CYP17 inhibitor still a treatment option for him?
TN1932
in
Advanced Prostate Cancer
2 years ago
Terbium-161 instead of Lutetium-177
VIOLET: A phase I/II trial evaluation of radioligand treatment in men with metastatic
castration
-resistant prostate cancer with [161Tb]Tb-PSMA-I&T. https://meetings.asco.org/abstracts-presentations/217246
VIOLET: A phase I/II trial evaluation of radioligand treatment in men with metastatic
castration
-resistant prostate cancer with [161Tb]Tb-PSMA-I&T. https://meetings.asco.org/abstracts-presentations/217246
TeleGuy
in
Advanced Prostate Cancer
1 year ago
Мой опыт и мои мысли о прохождении радиолигандной терапии с использованием лиганда PSMA-617, содержащего изотопы 177Lu и 225Ac. Часть 2.
Also, I was advised to continue ADT in order to keep my Testosterone at
castration
values. Let me remind you that, by that time, I had not taken any antiandrogens. Dr.
Also, I was advised to continue ADT in order to keep my Testosterone at
castration
values. Let me remind you that, by that time, I had not taken any antiandrogens. Dr.
RusLand
in
Advanced Prostate Cancer
1 year ago
European Society for Medical Oncology Congress - ESMO 2023 - Two Significant Lutetium Trials -mCRPC
https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147459-esmo-2023-enza-p-anzup-1901-enzalutamide-and-177lu-psma-617-in-poor-risk-metastatic-
castration
-resistant-prostate-cancer-mcrpc-a-randomized-phase-2-trial.html?
https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147459-esmo-2023-enza-p-anzup-1901-enzalutamide-and-177lu-psma-617-in-poor-risk-metastatic-
castration
-resistant-prostate-cancer-mcrpc-a-randomized-phase-2-trial.html?
marnieg46
in
Fight Prostate Cancer
7 months ago
Opinions on Lu-PSMA-617 Clinical Trial
Hello all, my father’s oncologist has suggested we start looking into clinical trials or chemotherapy now for his metastatic
castration
resistant prostate cancer (metastasized to the coccyx/pelvic bone in 2019). The trial the oncologist suggested is in the title.
Hello all, my father’s oncologist has suggested we start looking into clinical trials or chemotherapy now for his metastatic
castration
resistant prostate cancer (metastasized to the coccyx/pelvic bone in 2019). The trial the oncologist suggested is in the title.
PHnerd
in
Advanced Prostate Cancer
2 years ago
When is it time to discuss death with your oncologist?
He is the coordinating researcher of CAPRI (
CAstration
-resistant Prostate cancer RegIstry) https://youtu.be/wwvQXJo2aJE
He is the coordinating researcher of CAPRI (
CAstration
-resistant Prostate cancer RegIstry) https://youtu.be/wwvQXJo2aJE
Darryl
Partner
in
Advanced Prostate Cancer
1 year ago
Rezvilutamide: new anti-androgen is better than Casodex added to ADT for newly diagnosed high-met HSPC. But is field too crowded?
It also significantly increased time to
castration
resistance by 79%. Like Nubeqa, Rezvilutamide doesn't appreciably penetrate the blood-brain barrier. There weren't any large differences in side effects.
It also significantly increased time to
castration
resistance by 79%. Like Nubeqa, Rezvilutamide doesn't appreciably penetrate the blood-brain barrier. There weren't any large differences in side effects.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Would like help in treatment options.
I didn't fully realize until a visit with my urologist for a bladder cancer clean up that the
castration
sensitivity ends at some point for every one. I have been riding along thinking I could stay sensitive for years.
I didn't fully realize until a visit with my urologist for a bladder cancer clean up that the
castration
sensitivity ends at some point for every one. I have been riding along thinking I could stay sensitive for years.
agyoung
in
Advanced Prostate Cancer
2 years ago
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