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Lethal strategy: use of i) Doxycycline (Hit-1: targeting mitochondria) and ii) Vitamin C (Hit-2: targeting glycolysis) to eradicate CSCs
In summary, we propose the combined use of i) Doxycycline (Hit-1: targeting mitochondria) and ii) Vitamin C (Hit-2: targeting glycolysis), which represents a new synthetic-lethal metabolic strategy for eradicating CSCs. This type of metabolic Achilles’ heel will allow us and others to more effectively
In summary, we propose the combined use of i) Doxycycline (Hit-1: targeting mitochondria) and ii) Vitamin C (Hit-2: targeting glycolysis), which represents a new synthetic-lethal metabolic strategy for eradicating CSCs. This type of metabolic Achilles’ heel will allow us and others to more effectively
Seasid
in
Advanced Prostate Cancer
11 months ago
RE iron tablet recommendations
Hi again I have to get my iron levels up.. I have one perscription from my GP for 305 mg Caps Ferrous fumurate (but when I go to the pharmacies here they only have Galfer which has sooo many horrible ingredients, some of which have been banned in Australia, some euro countries)... And my private Endo
Hi again I have to get my iron levels up.. I have one perscription from my GP for 305 mg Caps Ferrous fumurate (but when I go to the pharmacies here they only have Galfer which has sooo many horrible ingredients, some of which have been banned in Australia, some euro countries)... And my private Endo
ChristinaMay
in
Thyroid UK
6 months ago
Proton Therapy timeline question
For those who have had proton therapy, what was your timeline? What period of time elapsed after you began ADT and had the simulation? And then, how long after that did the actual therapy begin? I've been reading and can't seem to determine a timeline, other than one guy wrote that he had the simulation
For those who have had proton therapy, what was your timeline? What period of time elapsed after you began ADT and had the simulation? And then, how long after that did the actual therapy begin? I've been reading and can't seem to determine a timeline, other than one guy wrote that he had the simulation
Hidden
in
Advanced Prostate Cancer
9 months ago
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Would be grateful for your thoughts on my blood results before endo apt please, still feeling exhausted and weak. Thank you
Hello, I’ve had an underactive thyroid for 8 years after having my first child, looks like Hashimotos. Currently taking 100mcg levothyroxine and 15mcg liothyronine (10mcg on waking and 5 around 3pm). Also on HRT patches as am mid 40s and perimenopausal. I’m gluten free, have had SIBO in the past.
Hello, I’ve had an underactive thyroid for 8 years after having my first child, looks like Hashimotos. Currently taking 100mcg levothyroxine and 15mcg liothyronine (10mcg on waking and 5 around 3pm). Also on HRT patches as am mid 40s and perimenopausal. I’m gluten free, have had SIBO in the past.
Hopetoheal22
in
Thyroid UK
10 days ago
Increased my ferritin levels
Hi all,I have known about the RLS/iron link for many years however as my ferritin iron level has always been around 100 I haven't taken iron consistently.Five months ago I started "getting serious " in taking it every other night with vitamin C as even with my Zomorph and Pregablin I was still getting
Hi all,I have known about the RLS/iron link for many years however as my ferritin iron level has always been around 100 I haven't taken iron consistently.Five months ago I started "getting serious " in taking it every other night with vitamin C as even with my Zomorph and Pregablin I was still getting
Pippins2
in
Restless Legs Syndrome
22 days ago
avocado - anyone else ?
Hi and happy summer solstice, I’ve recently been trying to improve my diet and read that avocado has many good features, such as high fiber, good fat, vitamin c, b vitamins, folate, vitamin k, and something about it helps the body produce glutathione (an antioxidant which helps protect the liver.)
Hi and happy summer solstice, I’ve recently been trying to improve my diet and read that avocado has many good features, such as high fiber, good fat, vitamin c, b vitamins, folate, vitamin k, and something about it helps the body produce glutathione (an antioxidant which helps protect the liver.)
Greengal314
in
British Liver Trust
11 months ago
Please help me figure out what’s going on
I am a 28 year old woman with most of the symptoms of hypothyroidism: - extreme lethargy (I need to sleep at least 10 hours a night and nap during the day) - zero libido - periods all over the place (sometimes 28 days apart, sometimes 40) - hair falling out - have put on weight but have less of
I am a 28 year old woman with most of the symptoms of hypothyroidism: - extreme lethargy (I need to sleep at least 10 hours a night and nap during the day) - zero libido - periods all over the place (sometimes 28 days apart, sometimes 40) - hair falling out - have put on weight but have less of
TiredReader
in
Thyroid UK
8 months ago
Blood test results in full. Can anyone find a cause in there for my continued fatigue etc?
I still have the same symptoms, although some have improved a bit, but not gone, by any means. Still housebound. I list below Blood test results. Can anyone suggest an issue that may cause my symptoms because my GP says no action, normal. Serum 25 - HO Vit D3 level 135nmol/L 50-174
I still have the same symptoms, although some have improved a bit, but not gone, by any means. Still housebound. I list below Blood test results. Can anyone suggest an issue that may cause my symptoms because my GP says no action, normal. Serum 25 - HO Vit D3 level 135nmol/L 50-174
DandyButch
in
Thyroid UK
12 days ago
AMA positive
hi I’m after some advise please 🙏🏼 guys my previous post mentioned a have a few very high LFT My own GP has done another test and noticed the liver specialist blood results mentioning I am AMA positive .. I’ve been prescribed Ursodeoxycholic 500mg twice a day via liver specialist. I have yet to
hi I’m after some advise please 🙏🏼 guys my previous post mentioned a have a few very high LFT My own GP has done another test and noticed the liver specialist blood results mentioning I am AMA positive .. I’ve been prescribed Ursodeoxycholic 500mg twice a day via liver specialist. I have yet to
Lollypop89
in
British Liver Trust
11 months ago
Alternatively this information may be helpful
Hi here is some information that might be useful black strap molasses for iron Moringa for iron and sleep with many nutrients Mangosteen for anxiety and depression Paw paw capsules for anxiety Okra Greek vegetable with many health benefits and helps the liver and kidneys how to possibly get off thyroxine
Hi here is some information that might be useful black strap molasses for iron Moringa for iron and sleep with many nutrients Mangosteen for anxiety and depression Paw paw capsules for anxiety Okra Greek vegetable with many health benefits and helps the liver and kidneys how to possibly get off thyroxine
RLSSCARER
in
Restless Legs Syndrome
7 months ago
Post double ankle sprain rehab
Hi all, I managed to sprain both ankles, falling off a high curb, but at the beginning of a 450km cycle tour. Although I could not walk well, I could cycle with discomfort only under exertion. Given that I had was committed to the tour, I continued with pain-killers, an ankle support for the most affected
Hi all, I managed to sprain both ankles, falling off a high curb, but at the beginning of a 450km cycle tour. Although I could not walk well, I could cycle with discomfort only under exertion. Given that I had was committed to the tour, I continued with pain-killers, an ankle support for the most affected
TonyBartlett
in
Couch to 5K
11 months ago
Help with Labs?
I had been seeing a Functional doctor privately but lost job and cannot really afford a consultation at the moment. secersl years ago a Bluehorizon test showed high RT3 and I was put on liothyronine 50mcg per day and 50 Levo which I have remained taking to present. My gynae just ran some bloods which
I had been seeing a Functional doctor privately but lost job and cannot really afford a consultation at the moment. secersl years ago a Bluehorizon test showed high RT3 and I was put on liothyronine 50mcg per day and 50 Levo which I have remained taking to present. My gynae just ran some bloods which
Dollyrocker000
in
Thyroid UK
19 days ago
Elevated ALT a problem?
Hello, I'm 33 year old female, who was diagnosed with fatty liver after pregnancy. I can't find any more info about my fatty liver, it just says fatty infiltration. My BMI is within range. I drink maybe once a month as I'm too worried about my liver, I just don't enjoy drinking. I have been told
Hello, I'm 33 year old female, who was diagnosed with fatty liver after pregnancy. I can't find any more info about my fatty liver, it just says fatty infiltration. My BMI is within range. I drink maybe once a month as I'm too worried about my liver, I just don't enjoy drinking. I have been told
DamagingGiraffe
in
British Liver Trust
1 year ago
That was a bit silly
I set my alarm for 7am this morning so I could run before it got too hot, after a night of the cat periodically poking at me and meowing and waking me up, I turned the alarm off and went back to sleep .So at 10.06am I was finally ready to go out. 6.4k or 4 mile's to do, I head towards the seafront and
I set my alarm for 7am this morning so I could run before it got too hot, after a night of the cat periodically poking at me and meowing and waking me up, I turned the alarm off and went back to sleep .So at 10.06am I was finally ready to go out. 6.4k or 4 mile's to do, I head towards the seafront and
SueAppleRun
60minGraduate
in
Bridge to 10K
11 months ago
what is the desired T4:T3 ratio? (because I don’t think this is it)
I just put all my latest lab results in the calculator and said “YIKES”! What ratio should I be shooting for? This doesn’t seem right — and I sure don’t feel well. Having the percentages really helps me understand just how low I am on B12 & D! Thanks always. - T4:T3 Ratio: 0.417 - Free T4: 1.25
I just put all my latest lab results in the calculator and said “YIKES”! What ratio should I be shooting for? This doesn’t seem right — and I sure don’t feel well. Having the percentages really helps me understand just how low I am on B12 & D! Thanks always. - T4:T3 Ratio: 0.417 - Free T4: 1.25
Hunny_BEE
in
Thyroid UK
9 months ago
covid recovery
hi all, Hubby had cold symptoms last week and tested positive, I felt ok at the time but had a faint line. Roll on 6 days I’ve had the all over aches, hot and cold sweats, pain in my throat, unbelievable sneezing and runny nose, a bit of a cough but not much. Most of that has gone except for that familiar
hi all, Hubby had cold symptoms last week and tested positive, I felt ok at the time but had a faint line. Roll on 6 days I’ve had the all over aches, hot and cold sweats, pain in my throat, unbelievable sneezing and runny nose, a bit of a cough but not much. Most of that has gone except for that familiar
Regenallotment
in
Thyroid UK
7 months ago
On T3 mono and Ferritin is 17 below rage
considerationHi I am on T3 mono and have been for quite a few years now and all I can see is people's iron goes up on T3 mono and Im the opposite and have hardly any iron. I had a FiT test so not bleeding I keep getting the runs on the iron tablets and stools have only been dark once I take vitamin
considerationHi I am on T3 mono and have been for quite a few years now and all I can see is people's iron goes up on T3 mono and Im the opposite and have hardly any iron. I had a FiT test so not bleeding I keep getting the runs on the iron tablets and stools have only been dark once I take vitamin
Pascha1
in
Thyroid UK
2 months ago
Living With A-Fib Questions
Hi All, I was diagnosed with A-Fib only a few weeks ago so everything is still very new and a bit bewildering. I think I was first aware that something wasn't right around 3 months ago when I noticed I got much more out of breath walking up a hill then I would normally be. A couple of days later I noticed
Hi All, I was diagnosed with A-Fib only a few weeks ago so everything is still very new and a bit bewildering. I think I was first aware that something wasn't right around 3 months ago when I noticed I got much more out of breath walking up a hill then I would normally be. A couple of days later I noticed
PeakyO
in
AF Association
11 months ago
Is this PMR?
Hello I'm new to this site and to the world of PMR. Hoping to get some guidance from this lovely community. My GP has diagnosed me with PMR at 42 and I'm not entirely convinced as I don't fit the symptoms of aches and stiffness in the shoulders and hips. This all started in March 23 where I woke
Hello I'm new to this site and to the world of PMR. Hoping to get some guidance from this lovely community. My GP has diagnosed me with PMR at 42 and I'm not entirely convinced as I don't fit the symptoms of aches and stiffness in the shoulders and hips. This all started in March 23 where I woke
Evie1977
in
PMRGCAuk
10 months ago
neuropathy?
I am still awaiting my first rheumatologist appointment. My labs weren’t awful - ANA & CCP negative, but Rheumatoid factor 191 and slightly elevated Sed Rate and C-reactive protein. I had had very brief (20 seconds or less) bouts of vertigo and 6 falls in 9 months - so my doctor ordered and MRI and
I am still awaiting my first rheumatologist appointment. My labs weren’t awful - ANA & CCP negative, but Rheumatoid factor 191 and slightly elevated Sed Rate and C-reactive protein. I had had very brief (20 seconds or less) bouts of vertigo and 6 falls in 9 months - so my doctor ordered and MRI and
Jojosteeler
in
NRAS
1 year ago
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