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EMBARK Trial: Combination-therapy is better.
This chart compares the risk of developing metastasis from prostate cancer, after 5 years from curative treatment, between three different arms of the EMBARK study (published in 2023): (1) Lupron monotherapy; (2) Enzalutamide monotherapy; and (3) Enzalutamide + Lupron combination therapy. The cohort
This chart compares the risk of developing metastasis from prostate cancer, after 5 years from curative treatment, between three different arms of the EMBARK study (published in 2023): (1) Lupron monotherapy; (2) Enzalutamide monotherapy; and (3) Enzalutamide + Lupron combination therapy. The cohort
janebob99
in
Prostate Cancer Network
20 days ago
3 Abiraterone tabs in place of 4.
Warriors Some time back I posted that my MO had told me to take 3 Abiraterone tablets with 5 mg Prednisone daily instead of 4 to help with an out of control Blood Pressure problem. I was worried (as were some of the responses) that this could impact the ADT therapy. Recently had blood work done
Warriors Some time back I posted that my MO had told me to take 3 Abiraterone tablets with 5 mg Prednisone daily instead of 4 to help with an out of control Blood Pressure problem. I was worried (as were some of the responses) that this could impact the ADT therapy. Recently had blood work done
85236442968
in
Advanced Prostate Cancer
20 days ago
Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy.
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
cigafred
in
Fight Prostate Cancer
20 days ago
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Any adverse effect if taking three-month Lupron shot two weeks late?
Hi friends, my father has been on Lupron shots every three months with Abiraterone pills for about a year now. His next shot will be 14 weeks due to some insurance problems. What is the ideal and acceptable time range between shots that won’t risks benefits of treatment? What is the out of pocket price
Hi friends, my father has been on Lupron shots every three months with Abiraterone pills for about a year now. His next shot will be 14 weeks due to some insurance problems. What is the ideal and acceptable time range between shots that won’t risks benefits of treatment? What is the out of pocket price
qidao23
in
Advanced Prostate Cancer
20 days ago
If PSA is Suppressed by Doublet ADT, Will Salvage IMRT Cause a PSA Rise?
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
103532
in
Advanced Prostate Cancer
21 days ago
HDR Brachytherapy after initial RT
Anyone has a success story to share on using HDR Brachytherapy 2-3 years after initial Radiation of the prostate gland in case of recurrence of cancer? Thank you for sharing your story.
Anyone has a success story to share on using HDR Brachytherapy 2-3 years after initial Radiation of the prostate gland in case of recurrence of cancer? Thank you for sharing your story.
Simonapo
in
Advanced Prostate Cancer
21 days ago
is this cancer?
i’ve posted on here once for a scare, i’m back again. i’m 24 years old, and my poop has just not been super normal since i have had the thought it could be colon cancer. i have a spot on my lower left abdominal area, right below belly button, i assumed it to be a hernia. my doctor sent me for an ultrasound
i’ve posted on here once for a scare, i’m back again. i’m 24 years old, and my poop has just not been super normal since i have had the thought it could be colon cancer. i have a spot on my lower left abdominal area, right below belly button, i assumed it to be a hernia. my doctor sent me for an ultrasound
imscaredofcancer
in
Colon Cancer Connected
22 days ago
Timing of Docetaxel
Hello. Am now in year 10. Details in profile. For 2+ years have been taking Zoladex, Zytiga and Prednisolone. The CT bone scans and Nuclear medicine full body scans every 6 months show no radiographic progression and I feel ok, apart from fatigue when not active. Recently have some discomfort
Hello. Am now in year 10. Details in profile. For 2+ years have been taking Zoladex, Zytiga and Prednisolone. The CT bone scans and Nuclear medicine full body scans every 6 months show no radiographic progression and I feel ok, apart from fatigue when not active. Recently have some discomfort
Ian99
in
Advanced Prostate Cancer
22 days ago
10-year update still shows no benefit to ART vs early SRT
ART
= adjuvant radiation therapy, within 6 months after radical prostatectomy (RP)
early SRT
= salvage radiation therapy, after PSA ≥ 0.1ng/ml or 3 consecutive rises. Median was 0.2 ng/ml. Median 1 ½ years after RP. Patients risked nothing by waiting, and gained urinary and fecal continence
ART
= adjuvant radiation therapy, within 6 months after radical prostatectomy (RP)
early SRT
= salvage radiation therapy, after PSA ≥ 0.1ng/ml or 3 consecutive rises. Median was 0.2 ng/ml. Median 1 ½ years after RP. Patients risked nothing by waiting, and gained urinary and fecal continence
Tall_Allen
in
Advanced Prostate Cancer
22 days ago
Docetaxel Failing
Greetings from Inverness in the beautiful Highlands of Scotland! I would like to share my journey with you and hopefully get some advice on future treatments. In December 2022 following diagnoses of advanced prostate cancer with multiple bone metastasis I started zytiga + prednisone and 6 monthly triptorelin
Greetings from Inverness in the beautiful Highlands of Scotland! I would like to share my journey with you and hopefully get some advice on future treatments. In December 2022 following diagnoses of advanced prostate cancer with multiple bone metastasis I started zytiga + prednisone and 6 monthly triptorelin
Fisherman2
in
Advanced Prostate Cancer
22 days ago
BILLY NEEDS HELP
OK troops, after 26 years of surviving post prostectomy, with a Gleason 4/3, 4/4, some 41 rounds of intermittent hormone therapy using lupron, casadex, advodart, I had a break thru last November as my psa went back up mid on cycle. After having my radiation oncologist ignore the realities of this, I
OK troops, after 26 years of surviving post prostectomy, with a Gleason 4/3, 4/4, some 41 rounds of intermittent hormone therapy using lupron, casadex, advodart, I had a break thru last November as my psa went back up mid on cycle. After having my radiation oncologist ignore the realities of this, I
billyboy3
in
Advanced Prostate Cancer
22 days ago
Appropriate Treatment
I was diagnosed with stage 4 prostate cancer PSA 29.1 which had metastatised to lymph nodes, ribs & spine after a few months on Abiraterone and Prednisone my PSA count dropped to 0.06 After 30 months my PSA started to rise at 10.2 my treatment was declared ineffective Lutetium 177 treatment was recommended
I was diagnosed with stage 4 prostate cancer PSA 29.1 which had metastatised to lymph nodes, ribs & spine after a few months on Abiraterone and Prednisone my PSA count dropped to 0.06 After 30 months my PSA started to rise at 10.2 my treatment was declared ineffective Lutetium 177 treatment was recommended
154Eleventh
in
Advanced Prostate Cancer
23 days ago
10th year
Ten years ago I had my Gleason 9 prostate removed. PSA was .1 for a while. It crept up over .2, and I began taking lupron. The drug brought PSA back down to >.01 for a year or so. As the level started going up again, I received whole pelvis bed radiation, moving PSA to undetectable. After a year or so
Ten years ago I had my Gleason 9 prostate removed. PSA was .1 for a while. It crept up over .2, and I began taking lupron. The drug brought PSA back down to >.01 for a year or so. As the level started going up again, I received whole pelvis bed radiation, moving PSA to undetectable. After a year or so
Jvaughan0
in
Advanced Prostate Cancer
23 days ago
Bevacizumab v Niraparib
I've had chemo/debulking surgery/ chemo, and have just come to the end of the post surgery chemo. I've been told all along that I will continue with Bevacizumab as a maintenance treatment (I've had 3 rounds of it alongside chemo, 2 before the surgery and 1 after). I caught COVID towards the end of
I've had chemo/debulking surgery/ chemo, and have just come to the end of the post surgery chemo. I've been told all along that I will continue with Bevacizumab as a maintenance treatment (I've had 3 rounds of it alongside chemo, 2 before the surgery and 1 after). I caught COVID towards the end of
LovemyJackRussell
in
My Ovacome
23 days ago
Good News! Pluvicto Update
Hey Guys, I just had my third round of Pluvicto this last Tuesday. I had bloodwork done last week. The news seems promising: On 28 January (after docetaxel, but before Pluvicto), my PSA was 36.2. After 2 rounds of Pluvicto on 8 April, my PSA had dropped to 14.5! So, I am remaining positive! I have
Hey Guys, I just had my third round of Pluvicto this last Tuesday. I had bloodwork done last week. The news seems promising: On 28 January (after docetaxel, but before Pluvicto), my PSA was 36.2. After 2 rounds of Pluvicto on 8 April, my PSA had dropped to 14.5! So, I am remaining positive! I have
MJCA
in
Advanced Prostate Cancer
23 days ago
How do you know if radiation treatment worked?
I had 25 sessions of radiation to prostate and pelvic area as a precaution and 6 (2 months prior and 4 after radiation)months of Lupron. For 9 months post radiation PSA has been not been detectable and it has now risen to 0.04. T is in the normal range. All other blood works were normal. Meet with
I had 25 sessions of radiation to prostate and pelvic area as a precaution and 6 (2 months prior and 4 after radiation)months of Lupron. For 9 months post radiation PSA has been not been detectable and it has now risen to 0.04. T is in the normal range. All other blood works were normal. Meet with
Mgtd
in
Advanced Prostate Cancer
23 days ago
AI cancer article
Not sure I understand this. It's not a very good article. It discusses two different ways PCa evolves and possible different treatments can be developed. https://www.ox.ac.uk/news/2024-03-05-ai-reveals-prostate-cancer-not-just-one-disease
Not sure I understand this. It's not a very good article. It discusses two different ways PCa evolves and possible different treatments can be developed. https://www.ox.ac.uk/news/2024-03-05-ai-reveals-prostate-cancer-not-just-one-disease
gsun
in
Advanced Prostate Cancer
24 days ago
The University of California has raked in a previously undisclosed $1.6 billion from Xtandi sales sales
Here's an edited version of the article, from "The Lever" Research universities, many of them public, have joined forces with pharmaceutical companies and Wall Street firms to fight new government efforts to curtail out-of-control drug prices, saying the regulations could stifle innovation. But these
Here's an edited version of the article, from "The Lever" Research universities, many of them public, have joined forces with pharmaceutical companies and Wall Street firms to fight new government efforts to curtail out-of-control drug prices, saying the regulations could stifle innovation. But these
rsgdmd
in
Advanced Prostate Cancer
24 days ago
Recurrence of borderline?
Hi everyone, a year ago I had TAH-BSO by laparotomy and my pathology was stage 1a seromucinous borderline ovarian tumour. I felt great after the surgery and thought I was all done with this. But for the past several weeks I have been having bloating, fatigue, abdominal and low back pain, and needing
Hi everyone, a year ago I had TAH-BSO by laparotomy and my pathology was stage 1a seromucinous borderline ovarian tumour. I felt great after the surgery and thought I was all done with this. But for the past several weeks I have been having bloating, fatigue, abdominal and low back pain, and needing
Mothbag
in
My Ovacome
24 days ago
Improving Symptoms with Rising PSA
If prostate symptoms [i]
(less urinary frequency/less urgent urination/finally can sleep through night)
[/i] are improving, but PSA is increasing
(from 10 to15)
over last few years where at
10
MRI was negative, what does kind of pattern indicate or suggests?
If prostate symptoms [i]
(less urinary frequency/less urgent urination/finally can sleep through night)
[/i] are improving, but PSA is increasing
(from 10 to15)
over last few years where at
10
MRI was negative, what does kind of pattern indicate or suggests?
back2health
in
Advanced Prostate Cancer
24 days ago
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