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Time to PSA Nadir is related to progression-free-survival
This graph from Teoh (2014) plots the relationship between Time to PSA Nadir (months) versus Time to Progression (months) (i.e., Progression Free Survival). Cohort: ADT monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points
This graph from Teoh (2014) plots the relationship between Time to PSA Nadir (months) versus Time to Progression (months) (i.e., Progression Free Survival). Cohort: ADT monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points
janebob99
in
Advanced Prostate Cancer
3 months ago
Testosterone was slowly recovering after stopping all meds 8/10/2023 then started dropping!
It looked like Provenge and SBRT last October had lowered and stabilized my rapidly rising PSA to around 1.8 for three months. Then three weeks ago it mysteriously doubled in a month to 3.1 A new PSMA scan showed four new scattered bone mets appearing since last PSMA scan 3 months prior. Micro mets
It looked like Provenge and SBRT last October had lowered and stabilized my rapidly rising PSA to around 1.8 for three months. Then three weeks ago it mysteriously doubled in a month to 3.1 A new PSMA scan showed four new scattered bone mets appearing since last PSMA scan 3 months prior. Micro mets
SViking
in
Advanced Prostate Cancer
3 months ago
Abiraterone seems to be working
An update on my situation. To review, I now appear to be castrate resistant after about 6 1/2 years of being castrate sensitive. My MO put me on Abiraterone, along the existing Lupron. I had my MO appt and my PSA has fallen from 4.5 to 2 after about 7 weeks on Abi. This is my second iteration with Abi
An update on my situation. To review, I now appear to be castrate resistant after about 6 1/2 years of being castrate sensitive. My MO put me on Abiraterone, along the existing Lupron. I had my MO appt and my PSA has fallen from 4.5 to 2 after about 7 weeks on Abi. This is my second iteration with Abi
fireandice123
in
Advanced Prostate Cancer
3 months ago
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Exercise post surgery
Hi, I appreciate there are other more serious matters of concern but I would just like to know what types of exercise and when you started after lung surgery. I am bored with physio and less motivated to walk everyday!
Hi, I appreciate there are other more serious matters of concern but I would just like to know what types of exercise and when you started after lung surgery. I am bored with physio and less motivated to walk everyday!
GGoyster
in
The Roy Castle Lung Cancer Foundation
3 months ago
Eligard injection site
I’m changing from 3 month Lupron to 6 month Eligard. Lupron has always been injected in my hip and I’m wondering if Eligard can also use the same site. Thanks in advance for your comments.
I’m changing from 3 month Lupron to 6 month Eligard. Lupron has always been injected in my hip and I’m wondering if Eligard can also use the same site. Thanks in advance for your comments.
Lslal
in
Advanced Prostate Cancer
3 months ago
Using Enzalutamide, Darolutamide, Apalutamide only.
I've seen a number of posters here and there who say they use one of the "mides" listed above with no ADT like Lupron, Eligard, Firmagan, or Orgovyx, etc. If so, did you begin that regimen after being on first level ADT for a while along with the 'mide," or did you start on the "mide" alone at the start
I've seen a number of posters here and there who say they use one of the "mides" listed above with no ADT like Lupron, Eligard, Firmagan, or Orgovyx, etc. If so, did you begin that regimen after being on first level ADT for a while along with the 'mide," or did you start on the "mide" alone at the start
dhccpa
in
Prostate Cancer Network
3 months ago
Docetaxel - how many rounds did you have?
With my husband's recent PSA reading of 5 (down from 162 before we started chemo), it appears still to be working for him. Our MO plans to continue as long as it works and his body tolerates it. Other than being a couch potato and having digestive issues for one week out of three, he's doing okay.
With my husband's recent PSA reading of 5 (down from 162 before we started chemo), it appears still to be working for him. Our MO plans to continue as long as it works and his body tolerates it. Other than being a couch potato and having digestive issues for one week out of three, he's doing okay.
Tinuriel
in
Advanced Prostate Cancer
3 months ago
Studies re: PSA > 0.5% after RT
Can anyone interpret the gist of these studies? Correct me if I am wrong (and I sure hope to be) but from what I am gleaning, it seems that for those who have RT and a concurrent round of ADT: 1) Researchers and studies are showing that waiting 18 months to reach a post RT nadir isn't necessary to determine
Can anyone interpret the gist of these studies? Correct me if I am wrong (and I sure hope to be) but from what I am gleaning, it seems that for those who have RT and a concurrent round of ADT: 1) Researchers and studies are showing that waiting 18 months to reach a post RT nadir isn't necessary to determine
quietcorner
in
Advanced Prostate Cancer
3 months ago
6 Month Eligard
I got my results from PSA/PET last week, showing no metastatic activity anywhere, bones and lymph nodes clear. My last Gleason score was 4+3 in 1 sample, 3+3 in 2 more same side, but focus of intraductal cancer in 2 cores on other side. Last PSA 5.3 in February, stable between 5.0 and 5.8 last 2 years
I got my results from PSA/PET last week, showing no metastatic activity anywhere, bones and lymph nodes clear. My last Gleason score was 4+3 in 1 sample, 3+3 in 2 more same side, but focus of intraductal cancer in 2 cores on other side. Last PSA 5.3 in February, stable between 5.0 and 5.8 last 2 years
SherpaT
in
Prostate Cancer Network
3 months ago
psa rising
After a second rise in psa from .04 to .21 in three months we decided to meet with a medical oncologist to discuss next steps. I am inclined to get a scan to locate pc but it may be too low. I have had surgery followed by salvage radiation followed by a scan and pelvic radiation so I may have exhausted
After a second rise in psa from .04 to .21 in three months we decided to meet with a medical oncologist to discuss next steps. I am inclined to get a scan to locate pc but it may be too low. I have had surgery followed by salvage radiation followed by a scan and pelvic radiation so I may have exhausted
Howard53545
in
Advanced Prostate Cancer
3 months ago
Lung cancer
Diagnosed with lung cancer very high in lung, Doctor says it's very difficult to get for biopsy, and then tells me that as I weigh 130 kg I might not be suitable for radiotherapy, is this right?
Diagnosed with lung cancer very high in lung, Doctor says it's very difficult to get for biopsy, and then tells me that as I weigh 130 kg I might not be suitable for radiotherapy, is this right?
Marydoll55
in
The Roy Castle Lung Cancer Foundation
3 months ago
Dutasteride Black Box Warning Label is Inappropriate.
This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on Dutasteride prescriptions. https://pubmed.ncbi.nlm.nih.gov/12824459/ There are some important points that should be considered: (1) Thompson only studied
This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on Dutasteride prescriptions. https://pubmed.ncbi.nlm.nih.gov/12824459/ There are some important points that should be considered: (1) Thompson only studied
janebob99
in
Prostate Cancer Network
3 months ago
Acute Liver Failure Diagnosis
On Tuesday, I finally received the long awaited Truqap. I was told to hold off beginning treatment and to bring the medicine to the oncologist's off on Thursday. The oncologist took one look at me and dropped her jaw in awe of my yellow skin color, which I could not see, then shipped me off to the
On Tuesday, I finally received the long awaited Truqap. I was told to hold off beginning treatment and to bring the medicine to the oncologist's off on Thursday. The oncologist took one look at me and dropped her jaw in awe of my yellow skin color, which I could not see, then shipped me off to the
jersey-jazz
in
SHARE Metastatic Breast Cancer
3 months ago
3year Updates w/PSA Graph
Hi Everyone, I'd like to report my 3 year journey. Initial PSA 27 in 6/20. Diagnosed w/PC 10/20. Gleason score is 3+4 (high-risk). My T-stage is T2a/T2b. CT Scan showed no lymph node & Bone Scan showed some indication of met. PSMA/PET in 1/12/21 showed no met outside. Started ADT (Lupron
Hi Everyone, I'd like to report my 3 year journey. Initial PSA 27 in 6/20. Diagnosed w/PC 10/20. Gleason score is 3+4 (high-risk). My T-stage is T2a/T2b. CT Scan showed no lymph node & Bone Scan showed some indication of met. PSMA/PET in 1/12/21 showed no met outside. Started ADT (Lupron
brucesam
in
Advanced Prostate Cancer
3 months ago
Length of Treatment for Orgovyx (Relugolix) versus Lupron and other Longer Acting ADT drugs as Adjuvant to RT or Used for IADT?
I'm curious if anyone has had any discussion with their MO or Radiation Oncologist about having to take a longer course of Orgovyx compared to Lupron or other longer acting ADT drugs because Testosterone comes back so much quicker on Orgovyx? It would seem to me, 6 months of Orgovyx is like the equivalent
I'm curious if anyone has had any discussion with their MO or Radiation Oncologist about having to take a longer course of Orgovyx compared to Lupron or other longer acting ADT drugs because Testosterone comes back so much quicker on Orgovyx? It would seem to me, 6 months of Orgovyx is like the equivalent
jazj
in
Advanced Prostate Cancer
3 months ago
Xtandi side effect full body rash
Has anyone had a side effect when taking Xtandi. An allergic reaction of full body itchy burning unbearable rash after taking it a week. Took Abiraterone for 4 years with no side effects. PSA started to rise so was switched to Xtandi. They took me off the drug but the rash is horrible. taking prednisone
Has anyone had a side effect when taking Xtandi. An allergic reaction of full body itchy burning unbearable rash after taking it a week. Took Abiraterone for 4 years with no side effects. PSA started to rise so was switched to Xtandi. They took me off the drug but the rash is horrible. taking prednisone
Gern
in
Advanced Prostate Cancer
3 months ago
promising delivery technique for cancer drugs
we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!) https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c01540# from your one reference in the paper: Chondroitin sulfate-hybridized zein nanoparticles
we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!) https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c01540# from your one reference in the paper: Chondroitin sulfate-hybridized zein nanoparticles
Maxone73
in
Advanced Prostate Cancer
3 months ago
Maybe an alternative to Nattokinase et al, though not yet
Free link to WSJ article https://www.wsj.com/health/pharma/blood-thinners-prevent-clots-bleeding-abd9fdae?st=ofx7h2a2im27x9c&reflink=desktopwebshare_permalink I will study later, but the chemistry is probably beyond me and, anyway, it is not yet available. Factor XI, it turns out, is crucial for
Free link to WSJ article https://www.wsj.com/health/pharma/blood-thinners-prevent-clots-bleeding-abd9fdae?st=ofx7h2a2im27x9c&reflink=desktopwebshare_permalink I will study later, but the chemistry is probably beyond me and, anyway, it is not yet available. Factor XI, it turns out, is crucial for
cigafred
in
Fight Prostate Cancer
3 months ago
SalllyJones
My husband was diagnosed in Jan. 2022 by his Urologist for Stage 3b Highly Aggressive (label they gave it) prostate cancer, Gleason score of 8, into seminal vessicles, but no mets seen on PET Scan. Received Lupron for 18 months and Casodex 50mg was initiated immediately and continued once a day
My husband was diagnosed in Jan. 2022 by his Urologist for Stage 3b Highly Aggressive (label they gave it) prostate cancer, Gleason score of 8, into seminal vessicles, but no mets seen on PET Scan. Received Lupron for 18 months and Casodex 50mg was initiated immediately and continued once a day
SallyJones
in
Advanced Prostate Cancer
3 months ago
Help with Results
I just updated my Bio and just received my PSMA Gallium scan results. Appointment is tomorrow to review but from what I see even with a low PSA of 0.052 a lymph node lit up which is rare. Is this correct and given this my guess SOC is whole pelvic adjuvant radiation and higher dose to lymph nodes or?
I just updated my Bio and just received my PSMA Gallium scan results. Appointment is tomorrow to review but from what I see even with a low PSA of 0.052 a lymph node lit up which is rare. Is this correct and given this my guess SOC is whole pelvic adjuvant radiation and higher dose to lymph nodes or?
Peppertree602
in
Advanced Prostate Cancer
3 months ago
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