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TA Stampede Trial Q
Hey Tall guy When "3 years of ADT and 2 years of
abiraterone
is standard-of-care" How is that timed? Start ADT and Abi together, and stop Abi at 2 years leaving ADT by itself for the last year? How would that work in my case? I started ADT and Abi at the same time, then RT after 6 months.
Hey Tall guy When "3 years of ADT and 2 years of
abiraterone
is standard-of-care" How is that timed? Start ADT and Abi together, and stop Abi at 2 years leaving ADT by itself for the last year? How would that work in my case? I started ADT and Abi at the same time, then RT after 6 months.
Hidden
in
Advanced Prostate Cancer
10 months ago
PSMA PET and PSA
Hi, my Dad was diagnosed with PC 2 years ago, had Radiation and has been on Lupron,
Abiraterone
and Prednisone ever since.
Hi, my Dad was diagnosed with PC 2 years ago, had Radiation and has been on Lupron,
Abiraterone
and Prednisone ever since.
Simonapo
in
Advanced Prostate Cancer
10 months ago
PSMA PET scan?
I have been taking
abiraterone
& lupron & I am considering a treatment 'holiday'. Would a PSMA PET scan be beneficial ?
I have been taking
abiraterone
& lupron & I am considering a treatment 'holiday'. Would a PSMA PET scan be beneficial ?
davidw777
in
Advanced Prostate Cancer
1 year ago
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If it doesn't make you feel bad, is it working?
He has "failed" both apalutamide and
abiraterone
and is officially castrate resistant. Initial diagnosis was such that he was not offered triple therapy (he was low volume in Feb 2022). After the second treatment, his PSA had gone down to 22 from 41. After the third, it had increased to 25.
He has "failed" both apalutamide and
abiraterone
and is officially castrate resistant. Initial diagnosis was such that he was not offered triple therapy (he was low volume in Feb 2022). After the second treatment, his PSA had gone down to 22 from 41. After the third, it had increased to 25.
MiaAmia
in
Advanced Prostate Cancer
9 months ago
FDA approves olaparib/abiraterone for BRCA-positive mCRPC
https://www.urologytimes.com/view/fda-approves-olaparib-
abiraterone
-for-brca-positive-mcrpc?utm_source=sfmc&utm_medium=email&utm_campaign=05312023_UT_BREAKINGNEWS&eKey=b3NoZWFwNjQ2QGdtYWlsLmNvbQ==
https://www.urologytimes.com/view/fda-approves-olaparib-
abiraterone
-for-brca-positive-mcrpc?utm_source=sfmc&utm_medium=email&utm_campaign=05312023_UT_BREAKINGNEWS&eKey=b3NoZWFwNjQ2QGdtYWlsLmNvbQ==
pca2004
in
Fight Prostate Cancer
1 year ago
FYI: New data on progression of visceral mets without PSA progression (discordance) and ARAT/docetaxel therapy
.,
abiraterone
and enzalutamide) may be susceptible to discordant progression. With the incorporation of early ARAT in SOC, we may see this number rise.
.,
abiraterone
and enzalutamide) may be susceptible to discordant progression. With the incorporation of early ARAT in SOC, we may see this number rise.
SeosamhM
in
Advanced Prostate Cancer
9 months ago
Final STAMPEDE results for Abi with/out Enza when starting ADT.
"Median follow-up was 96 months ... in the
abiraterone
trial and 72 months ... in the
abiraterone
and enzalutamide trial. "In the
abiraterone
trial, median overall survival was 76·6 months ... in the
abiraterone
group versus 45·7 months ... in the standard of care group ...
"Median follow-up was 96 months ... in the
abiraterone
trial and 72 months ... in the
abiraterone
and enzalutamide trial. "In the
abiraterone
trial, median overall survival was 76·6 months ... in the
abiraterone
group versus 45·7 months ... in the standard of care group ...
pca2004
in
Fight Prostate Cancer
1 year ago
Whole pelvic radiation after testicular cancer?
His treatment consisted of 39 radiation sessions + 2 yrs of Lupron +
Abiraterone
/Prednisone. He’s extremely active, works out almost every day and we still mountain bike and hike all over our beautiful Colorado.
His treatment consisted of 39 radiation sessions + 2 yrs of Lupron +
Abiraterone
/Prednisone. He’s extremely active, works out almost every day and we still mountain bike and hike all over our beautiful Colorado.
Adendino
in
Advanced Prostate Cancer
8 months ago
Advice Needed, Abiraterone Failing?
I started
Abiraterone
in November 2022 and my recent monthly PSA readings have been 5.65, 5.37, 6.11, 5.67, 5.66, 5.64, 6.41, 6.96, and 8.20ng/ml while taking
Abiraterone
. My consultant informs me my PC is very aggressive and hard to deal with. He also told me he sees my type in about 1 in 100 men.
I started
Abiraterone
in November 2022 and my recent monthly PSA readings have been 5.65, 5.37, 6.11, 5.67, 5.66, 5.64, 6.41, 6.96, and 8.20ng/ml while taking
Abiraterone
. My consultant informs me my PC is very aggressive and hard to deal with. He also told me he sees my type in about 1 in 100 men.
scranbag
in
Advanced Prostate Cancer
11 months ago
Abiraterone and heart failure
husband has had to go on
Abiraterone
earlier than we thought as the 6 sessions of chemo failed to do anything for his bone mets. We’re aware that med leaflets have to list every possible side effect but the Abi leaflet says 1 out of 10 people will get heart failure when taking it!!!
husband has had to go on
Abiraterone
earlier than we thought as the 6 sessions of chemo failed to do anything for his bone mets. We’re aware that med leaflets have to list every possible side effect but the Abi leaflet says 1 out of 10 people will get heart failure when taking it!!!
NLondon43
in
Advanced Prostate Cancer
11 months ago
More Evidence Linking ADT for PCa to Adverse Neurocognitive Effects -Meta-analysis shows increased risk of dementia, Parkinson's, depression
The risk was even higher in men treated with newer androgen receptor signaling inhibitors (ARSIs), but the association was not consistent across the ARSI class: increased risk with enzalutamide (Xtandi) and apalutamide (Erleada) but decreased risk with
abiraterone
(Zytiga).
The risk was even higher in men treated with newer androgen receptor signaling inhibitors (ARSIs), but the association was not consistent across the ARSI class: increased risk with enzalutamide (Xtandi) and apalutamide (Erleada) but decreased risk with
abiraterone
(Zytiga).
cujoe
in
Fight Prostate Cancer
4 months ago
A Clinical Trial saved my Life ..12 years a Survivor of Advanced Metastatic Prostate Cancer, Stage 4.
Twelve years later, Alfred says: “
Abiraterone
has saved my life and I am grateful for that. But not everyone is as fortunate as I was to get on that trial and respond to the drug as well as I did. We need more treatments like
abiraterone
.
Twelve years later, Alfred says: “
Abiraterone
has saved my life and I am grateful for that. But not everyone is as fortunate as I was to get on that trial and respond to the drug as well as I did. We need more treatments like
abiraterone
.
alsam
in
Understanding Clinical Trials
3 months ago
Oligomets and SBRT: "Whack a Mole"?
Then clinicians will be considering agents approved in the metastatic castration sensitive prostate cancer (mCSPC) such as docetaxel, apalutamide, enzalutamide, or
abiraterone
.
Then clinicians will be considering agents approved in the metastatic castration sensitive prostate cancer (mCSPC) such as docetaxel, apalutamide, enzalutamide, or
abiraterone
.
FrankyB4
in
Advanced Prostate Cancer
8 months ago
Rechallenging with a previously failed treatment?
Now there are treatments/trials combining Olaparib with another med like
Abiraterone
, which I had also previously failed as a mono therapy. Could a combo now possibly benefit me??? The answer may simply be that you won't know until you try.
Now there are treatments/trials combining Olaparib with another med like
Abiraterone
, which I had also previously failed as a mono therapy. Could a combo now possibly benefit me??? The answer may simply be that you won't know until you try.
HopingForTheBest1
in
Advanced Prostate Cancer
10 months ago
PSA suppression
Incidentally, that phrase - rapid androgen cycling - brings to mind the work of Howard Scher [3] (2006) When
Abiraterone
and Enzalutamide were approved, I was briefly tempted. But however efficient they were at controlling PSA, the effects were transient for most men.
Incidentally, that phrase - rapid androgen cycling - brings to mind the work of Howard Scher [3] (2006) When
Abiraterone
and Enzalutamide were approved, I was briefly tempted. But however efficient they were at controlling PSA, the effects were transient for most men.
pca2004
in
Fight Prostate Cancer
4 months ago
Apalutamide vs Abiraterone for Deep PSA Response in MHSPC patients
While the number of patients were not exactly even in each group, the study indicates that apalutamide has a greater initial decrease in PSA than
abiraterone
.
While the number of patients were not exactly even in each group, the study indicates that apalutamide has a greater initial decrease in PSA than
abiraterone
.
NPfisherman
in
Fight Prostate Cancer
1 year ago
Range bounded adaptive therapy: abiraterone etc
Hi, Wondering if I can persuade myself to take
abiraterone
for recently confirmed mcrpc. Looking to maybe use range bounded adaptive ther. Has anyone whoexperimented with this and can help. Looking for the best way to proceed. Thanks and good luck
Hi, Wondering if I can persuade myself to take
abiraterone
for recently confirmed mcrpc. Looking to maybe use range bounded adaptive ther. Has anyone whoexperimented with this and can help. Looking for the best way to proceed. Thanks and good luck
Rickytarr
in
Fight Prostate Cancer
1 year ago
Need help to fight fatigue from Radium 223
Had 6 cycles of Chemo and then
Abiraterone
for 18+ months until it stopped being effective. Currently part of trial with Radium 223. Had 4 cycles already and 2 more to go. After this will likely have to switch to Enzalutamide and ADT.
Had 6 cycles of Chemo and then
Abiraterone
for 18+ months until it stopped being effective. Currently part of trial with Radium 223. Had 4 cycles already and 2 more to go. After this will likely have to switch to Enzalutamide and ADT.
Ronnie7C
in
Advanced Prostate Cancer
11 months ago
European Society for Medical Oncology Congress - ESMO 2023 - Two Significant Lutetium Trials -mCRPC
Participants had not previously been treated with chemotherapy or androgen receptor pathway inhibitors although prior treatment with
abiraterone
and/or docetaxel for hormone sensitive disease were allowed.
Participants had not previously been treated with chemotherapy or androgen receptor pathway inhibitors although prior treatment with
abiraterone
and/or docetaxel for hormone sensitive disease were allowed.
marnieg46
in
Fight Prostate Cancer
7 months ago
Silly Questions??
2) Why do some advanced prostate cancer patients have NO Chemo, and go directly to ADT +
Abiraterone
+Prednisone, while others begin treatment with chemo and radiation? What are the deciding criteria ??
2) Why do some advanced prostate cancer patients have NO Chemo, and go directly to ADT +
Abiraterone
+Prednisone, while others begin treatment with chemo and radiation? What are the deciding criteria ??
TommyCarz2
in
Advanced Prostate Cancer
3 months ago
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