Everolimus

[Suzie-Wong24]

Hi, just got confirmation from my doctor to stop taking everolimus because it made my liver enzymes to high. Has this happen to anyone else? I was trying to get an idea if they will start me with a different line of treatment. I thank God that there are different lines of treatments, my last treatment lasted 3 years, I am grateful for that.

[13plus]

Hi Suzie, That must be frustrating. How long have you taken it, and what were you on before? I was curious if you have had new scans recently and how they would know that the drug was specifically the cause of your enzyme levels to increase?

[Kerryd22 in reply to 13plus]

it’s a known but rare side effect.

[Suzie-Wong24 in reply to 13plus]

I had a scan two months ago that showed progression and will have another in a month. They are going by the bloodwork and guessing they want to see if by stopping the drug if that will make a diffrence.

[Suzie-Wong24 in reply to 13plus]

It has only been two months, next month is another scan. I was on Ibrance which worked for 3 years. My levels has always been normal until I started taking Everolimus so guessing that's why they are trying this to see if the numbers go to down.

[13plus in reply to Suzie-Wong24]

Do you have mets in your liver? That's what I am dealing with now so it's interesting to hear that that drug itself can cause the enzyme levels to increase (vs the cancer). I took iBrance for almost 3 years too

[Suzie-Wong24 in reply to 13plus]

No, I don't have mets to my liver according to my recent scan. I am praying that is not the case on my next scan. thanks.

[Silver126]

Everolimus didn’t make my liver enzymes higher. Alkaline Phosphatase went to normal levels during treatment and before it was high. Unfortunately, this treatment didn’t work for me.

[Kerryd22]

yes it happened to me. I stayed on Exemestane though as I hadn’t progressed. I’m still on Exemestane 7 years later with stable disease.

[Dragonfighter in reply to Kerryd22]

Can I ask if exemestane was your first line of treatment? I am asking because I have been on palbociclib and letrozole for three years and am worried about what comes next. Scans next month and getting very nervous!

[Suzie-Wong24 in reply to Dragonfighter]

This is my second line... first was Ibrance and it worked for 3 years with minimum side effects. I thank God I got a few years out of that drug.

[Dragonfighter in reply to Suzie-Wong24]

Thank-you, you just made me a lot less worried. I am glad you are doing well!

[Kerryd22 in reply to Dragonfighter]

I was on Letrazole briefly but it did nothing. I had six months of Abraxane then everolimus and Exemestane. I had ten months of everolimus but stopped due to the liver problems. Stayed on Exemestane alone up until now.

[Suzie-Wong24 in reply to Kerryd22]

Hi, that was my main concern was if they would start a new treatment plan or just take me off for a short time if my next scans show it is working. Thanks.

[Kerryd22 in reply to Suzie-Wong24]

if you haven’t had progression then you can stay on Exemestane alone until you do get progression. That’s the case here anyway.

[Suzie-Wong24 in reply to Kerryd22]

Oh my God.. that is great. Good for you. I pray I have the same situation. I have another scan next month.