giredestrant with Everolimus trial

[Ticket123]

Ibrance and Fulvestrant stopped working. 😢oncologist wants me to do this trial. Has anybody had any experience with this trial or either drug?? Thanks for your help. Carla

[fancydog]

I'm curious why your Onc would suggest a clinical trial so quickly? Have you been checked for the ESR1 mutation? You could be a candidate for the new Elascetrant. And you could try other Meds Verzenio, Kisqali with Faslodex or an AI? Maybe this clinical trial is very promising and about to end with very good results.

[Kaydub in reply to fancydog]

The thinking behind doing clinical trials is that the standard of care treatment will always be available for you while the trial may not be. If the trial drug is successful it will still take years for FDA approval. This is the philosophy at the cancer care center I go to for my primary care as well as the one for my second opinion. Of course, they are also both research centers so take that for what it is.

[Ticket123 in reply to Kaydub]

yes that is the reasoning behind getting on the trial. To be on this trial your first line of treatment has to have stopped working. This has to be your second line. It’s the only time I can do it. There are 2 arms to the trial. I could either get put on the standard of care arm or the trial drug arm. Who knows.

[13plus in reply to Ticket123]

What would the standard of care be exactly?

[Ticket123 in reply to 13plus]

examestane and Everolimus would be the standard of care arm.

[13plus in reply to Ticket123]

I would think there is not so much to lose here with either arm of the trial (just my humble thoughts). Try googling though for "questions to ask about your trial" to help you feel at ease that you are satisfied with all you need to know about it.

[fancydog]

I just looked up Girdestrant indeed it looks very promising but is still in clinical trials.

[Ticket123 in reply to fancydog]

fingers crossed good things happen!!

[Kaydub]

Be aware that different phases have different requirements and time commitments. Also a consideration is whether they have determined the dosage.

[Ticket123 in reply to Kaydub]

yes I have to ask more questions, especially about the dosage and the flexibility of the dose!! I assume not very flexible

[13plus in reply to Kaydub]

Dosing is determined in the first Phase of a trial, though they may have variations they allow for Phase 2

[13plus]

Here is some info about the Giredestrant. I read somewhere else that it seems more promising for those whose hormones seem to be a real driver for their cancer to grow. onclive.com/view/giredestra...

[Ticket123 in reply to 13plus]

Thanks for the info. I’m not going to lie switching meds is kinda freaking me out. Talking about it is helpful. Thank you.

[13plus in reply to Ticket123]

Oh I know, it is scary! I’ve been through that twice now since being diagnosed with METS. Fortunately both times have ended up being ok but I fear I may have to switch sooner next time, so I’ll then be going through exactly what you are right now. I try to keep reassuring myself and have faith that all will be well. Some days are certainly easier then others but I do feel that keeping as positive a state as we can maintain, really helps us . I am struggling a bit with that at the moment though. This year has been a very challenging one for me so far, in a number of ways

[Ticket123 in reply to 13plus]

I’m sorry it’s been a challenging time this year. Funny (not funny) how the regular struggles don’t stop. I totally agree with the positive attitude. I am grateful for lots of things but sometimes just get so scared. I gave myself a day to melt and will hopefully shut it down and keep on moving today. Might as well try and enjoy my 2 week med freedom!!! I hope you have a good one!!!

[13plus in reply to Ticket123]

I don’t usually indulge but I went out today specifically to buy myself and indulge in some cake 😂