Interesting when drugs work on some things not the other

[Debbigbang]

So my story continues lol. I had 2 bone mets and a 3 cm leisions on my liver. Ibrance, letrozol got rid of the bone leisions. Didn't touch the liver, in fact it grew.

Off of Ibrance onto fulvestrant and letrozole. That kept everything at bay, but liver still grew. Now went from 3cm last yr to 9 cm. Had a biopsy, nothing strange, the liver leisions are the same as the primary secondary.

Apparently this can happen. The drugs will not work on some leisions.

So, we had to take the chemo route. I was never given the standard chemo route after my masectomy but right into the ibrance as they felt those were the treatments for breast cancer.

Now on xeloda. There was a bit of pressure on my liver side, which has gone. My onocologyst was pleased with that. Now starting 2nd round, ct scan will be done in a couple months. I know this will be the drug for me. There is no other cancels in my body currently. Thankfully this drug will kill the cancer floaters lol.

I was surprised this had happened. Has anybody run into this issue? Maybe it's an organ issue as I don't remember the bones doing that?

Just curious and thoughts. Cancer is a slippery bugger and smart!!! Always have to try to stay one step ahead of it, if that is even possible. Come on cure for this cancer 🙏

I miss Sandra as she would have had an input in clarity with this 😢

Deb ❤

[Silver126]

You’re not alone! The same happened to me. I was on Ribociclib and letrozole which worked on breast, lynphonodes and bone until I was NED. But after 4 months two liver mets appeared, too small for a biopsy. I’ve been on Xeloda since December and my PET scan on March stowed good remission. One spot disappeared, the other reduced in size and activity. Finger crossed 🤞🏻

[Debbigbang in reply to Silver126]

I am so happy you have positive progress!!! Gives me some much needed hope. This second round she gave me a lower dose as it was getting to be too much. I work full time and a single parent of 2 teenagers. I can't be on the sofa 24/7. Hopefully this will be it, right drug and right dosage.

But hey I just bought a stand up mixer and excited like a kid at Christmas LOL. Just got to keep positive even through the yucky part 🥰

Mbc is literally a game of wack a mole. One leision appears, get rid of it another pops up 🤦‍♀️

Deb ❤🙏

[Silver126 in reply to Debbigbang]

I feel much better than with Ribo+letrozole, no headache, hair is no more thin… just take care of your hands and feet, no hot and cold water, always use a lot of specific cream. I work full time too and I’m doing well😉Wish you all the best with this new treatment 🤞🏻🤞🏻🤞🏻🙏🙏🙏♥️

[Georgiamjb]

I was on Ibrance and switched to Xeloda. I've had great results in 3 months, but am now dealing with the hand/foot issue. We will lower the dose as soon as it is better so I am encouraged! Glad you see progress too!

[Debbigbang in reply to Georgiamjb]

I swear by this product Udderly Smooth cream. Works wonders !!!!

[8576]

Yes, I like Udderly Smooth cream also. It is odourless and disappears under the skin really quickly.

Cheers June S.

[Thatflowerlady]

Thank you for sharing your updated post . I am glad they are on the path to getting it figured out for you & hope that your new treatment is effective yet gentle on you . Whack a mole is a good analogy for MBC. Stand up mixers are an awesome kitchen appliance lol you will love it .

I am missing Sandra on our board also , I am sure many of us are. I am hoping she is doing well and taking good care of herself.

Keep us posted on your darn liver met . Have they suggested radiation treatment ?

Luann

[valentinecalico]

The same thing happened to me too! I was on Ibrance and letrozole for 2 years - worked well on the bone mets but then some liver mets appeared. They tried for a biopsy but were unable to get enough cells to test whether the receptors had changed. Anyway, I'm now on Abraxane - 6 sessions in total, 3rd one tomorrow - scans in June to see whether the lesions are responding. Fingers crossed for all of us! ❤️

[ChrisVict]

I had spots on my liver too small to biopsy but took Xeloda for 5 months initially no hand foot but then it kicked in. The liver spots were under the radar but it seemed tumor markers were rising onto next line so far liver has been stable.

[Debbigbang]

Mine is about 9 cm. I got a feeling it's working, won't know how much until my next CT scan. She dropped the does a bit, but constipated. Always a struggle between constipated or diarrhea with these meds. I don't care really, deal with it all if it works to stabilize

Deb

[Gibby21]

So this is happening to me right now as well just got the results of my CT scan. Many of the lesions in my liver are gone I have nothing in my bones lymph nodes or breast or anywhere else but I have two lesions in my liver that just refuse to play I just had a CT scan so I’m waiting for my appointment on Thursday to see what the doctor wants to do I don’t know if he’ll switch me I’ve been taking a lbrance with fulvestrant. Responding so well to this medicine and I’ve only been on it for a year so I really don’t wanna change. I wish there was somebody on here that could tell me why they don’t just do a little radiation on the two spots that won’t respond and break them up that way, why is that not a possibility? I haven’t heard anyone say anything about radiation?

[Debbigbang in reply to Gibby21]

Hi

My liver didn't respond to ibrance or fulvestrant . Why they do not. It went from a 3 cm to 9 cm. I am now on xeloda which is kicking me bad. I am on my 2nd treatment. I more to go then I will get a CT scan. I had pressure on my right side from the tumors, but do not feel it anymore. I will take this chemo beating if it gets rid of the tumors.

Canada is not great at radiation on the liver, there are a lot of blood vessels and areas that the liver could be damaged.

Deb