Ascende RT-trial: It has been five... - Prostate Cancer N...

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Ascende RT-trial

esperandrich profile image
10 Replies

It has been five years since the trial was published. Basically it said for high risk patients the combo of ADT, Radiation and Brachy was the way to go. Brachy Boost is the term I think.

I look on the internet for updates but can't find any.

Anybody heard about any updates on this info or know anything more?

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esperandrich profile image
esperandrich
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Tall_Allen profile image
Tall_Allen

I don't expect updates. They ran it long enough, IMO.

esperandrich profile image
esperandrich in reply to Tall_Allen

got it, thanks

Jancapper profile image
Jancapper

After conversing with a few other patients now who have also chosen brachytherapy boost along with ADT and EBRT, there seems to be some ambiguity regarding the best choice for ADT therapy. My RO informed me that I would go to completion (2 years) on Lupron alone, while Watertender is on Orgovyx single therapy. These are in agreement with the NCCN and AUA/ASTRO guidelines. However, the STAMPEDE protocol clearly states that Abiraterone should be added as well and should be considered SOC moving forward. I could use some help figuring this out.

esperandrich profile image
esperandrich in reply to Jancapper

I am not smart enough to help but my UCSD RO said 18 months of Lupron + the brachy boost was enough but everybody is different.

conbio profile image
conbio in reply to esperandrich

I did the same - EBRT, Brachy, 18 months Lupron - last shot a couple weeks ago. Also recommendation of Prostate Cancer Research Institute (Sholtz). youtube.com/watch?v=JSP4Utd...

Their take is - "Why extend ADT and it's side effects when 18 months has proven plenty enough?"

maley2711 profile image
maley2711 in reply to Jancapper

without looking at the SOC guidance you are reviewing, are you sure that the Abiraterone study group men had same characteristics as the characteristics that are mentioned for the men for which combo without Abiraterone is suggested? Maybe that trial was highlighting treatment for not just high risk, but for very high risk men? I believe such a trial is still ongoing? Sometimes a person must be VERY careful about understanding the exact nature of the study group?

Teacherdude72 profile image
Teacherdude72 in reply to Jancapper

Please understand these treatments are not one size fits all. Each of us is different, blood tests different, physical fitness different, mental state different, and attitude different.Also your doctor's interpretation of all these is different doc to doc.

Then add in your doctor's experience and you get different treatments.

Wishing you success in your chosen treatments.

SierraSix profile image
SierraSix in reply to Teacherdude72

That is my take. I'm local G9, My RO prescribed SBRT + 18months of Lupron. I discussed adding Brachy and he said I did not need it and it would add a lot of additional toxicity risk. We also discussed radiating the lymph nodes..etc and he gave me his logic/explanation to why we are only going to radiate the prostate. I told myself "He is the expert" and has a lot more experience/knowledge than little old me. I trust my doctor, so I let him prescribe what he thinks will give me the best chance for a curative solution. without making my QOL awfull.

Teacherdude72 profile image
Teacherdude72 in reply to SierraSix

Agree on your take. I will say that the HDR did not add to toxicity and I didn't have the spacearc because of the extent of the field of radiation. Also no rectal issues - 0.00%. Only difference is I was on Lupron 24 months.

A few years later back on Lupron and added Nubeqa.

Still all good and here to love life.

Best to you.

SierraSix profile image
SierraSix

in my case. I had a PSMA Pet that was clear.

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