I decided after consideration of safety and what is known or thought to be true about the treatment of B12 along with my experiences to test my hypothesis that more frequent injections might be superior to other trials I had done. And that no one had any information on increasing frequency that I had come across.
The hypothesis was not the result of finding what works. The last 90 days have been exploring that hypothesis.
I noticed very quickly when I started reading that it was odd that the protocol of EOD 1 mg of hydroxocobalamin was the most robust protocol and was suggested by symptoms and did not tie into established testing. I assumed I would come across the scientific rationale and to date have not. Nor any scientific reason increased frequency has not been tested but seems to be based on the belief injections by anyone other than medical personnel is not blessed.
4 months ago I started a trial of 1 mg of hydroxocobalamin and 1 mg of methylcobalamin 5 +- a day. Including injections if I woke up in the middle of the night. I spaced the injections a minimum 4 hours apart. My body adjusted which was hard, resulting in weekly improvement.
I did not experience any reversing out as I did when starving my cells of B12 even at 1.5 mg a day twice a day.
I did experience my body adjusting to having more B12 consistently. I could have seen what I experienced as side effects or caused by additives. I did not, based on my experience and critical research I expected that my body was adjusting and it was not side effects or caused by additives. That was born out as the experiences resolved.
I was surprised by how quickly I could get feedback which I attributed to having enough B12 consistently.
Conclusions:
1 mg of hydroxocobalamin and 1 mg of methylcobalamin 5 +- a day. Is superior to any protocol I have come across or designed except my current one.
1 mg Cyanocobalamin with 1 mg methylcobalamin is equivalent to 1 mg of hydroxocobalamin and 1 mg of methylcobalamin 5 +- a day
2 mg of methylcobalamin 5 +- alone caused too intense healing. I choose to consider that an upper limit for now.
Having found comfort in having an upper limit I chose to find my lower limit without taking the 6 mg Adenosylcobalamin SL I have taken for years. It was also in preparation to do a trial with injecting Adenosylcobalamin.
I established a lower limit to my satisfaction of 1 mg of B12 4 times a day.
After trying for 2 years I found a source of pharmaceutical grade adenosylcobalamin to mix with saline.
I choose not to share my source. It is a case of risk to me outweighing any potential benefit to the general good. That is absolute at this time.
Conclusion: Current trial of .75 mg of Adenosylcobalamin with .75 mg of Methylcobalamin. 3 times a day is superior to any other protocol I have tried or read about.
I will not be surprised if further trials show that methylcobalamin in the correct amount and frequency will be superior or equivalent to my current protocol. Or if 4 times a day utilizing my current trial is superior once my body heals more.
Have no training in the medical field. Am not claiming to be an expert. I am glad not to be in pain and suffer less. I am still ill. Not as ill as I was 8 days ago. The last 8 days have been difficult as my body adjusts and heals.
It is possible that why I am ill is from not having correct treatment until 8 weeks ago and I need to recover from those three years of exploration and discovery.
The most drastic improvement is that my digestive system which is affected by peripheral nephropathy has at least for the time being normalized.
Other than taking a probiotic in the morning I chose to solve my issues with B12 rather than start investigating other causes or solutions to my digestive system. Other than some home remedies like eating cheese when I had loose bowels.
I was diagnosed with gastritis but reviewed that diagnosis and found it was not valid and given to me only as the results of the PA test. I stopped that medication. No ethical diagnosis was made.
I did experience urinating more as my body adjusted to the changes in protocol. That seems to be resolved. Note: It is known that peripheral nephropathy will cause frequent urination.