Hi guys
Just a little question to throw out there:
I tested positive to intrinsic factor antibody 3 months ago now doing cyano shots monthly and has helped heaps with neuro symptoms.
I recently was tested and came back with low parathyroid hormone 8 range 10-65 and need to go back to dr for consult.
I read that pa may also attack the parathyroid glands among other parts has anyone else experienced this? and are you on treatment for this?
Thanks In Advance
No. PA cannot attack the parathyroids.
However, hypoparathyroidism can be caused by an autoimmune disease. And having one AI disease means you're more likely to suffer another.
I was diagnosed with hyperparathyroidism but nothing was followed up on
I am sorry that I have a War and Peace answer to your little question. It is not unusual for a person with one auto immune disease to develop another autoimmune issues. The problem is not in those organs where the disease seem to be manifesting but in immune system overreactivation so the T.reg cells are no longer able to regulate immune activity.
Research is suggesting molecular mimicry as the underlying mechanism-our own body proteins look similar molecularly to those of non-self -an example is thyroid enzyme protein (self) and gliadin (protein in wheat).... structurally looking almost identical.
What can be helpful is figuring out what is irritating your immune system. Infections and allergies/sensitivities to food have been implicated in the onset of autoimmunity (most likely mediated by stress) probably due to compromised gastrointestinal barrier, also referred to GI hyperpermiability or colloquially referred to as a ‘leaky gut’.
So it can go like this: you are stressed for a prolonged period of time, the chemistry of stress affects your GI environment and compromises your mucosal barrier that becomes ‘leaky’ which then allows undigested proteins from the gut to leak from the gut to lamina propria that is filled with immune cells - these cells then detect this undigested protein as a foreign invader, mark it and attack it. This causes inflammation, which can then keep the gut leaky. If your stress persist so will the leaky gut. This inflammation can then become systemic so it gets very difficult to trace back as where it originated. So the innocent molecule of gluten which was not an issue yesterday, suddenly becomes major immune system activator. So the only way to stop this is to figure out what the trigger is because just calming the symptoms will not resolve the cause!!
H.Pylori infection has been implicated in pathogenesis of PA and leaky gut. There are lots of interesting research articles on the subject. Here is one: ncbi.nlm.nih.gov/pmc/articl... for the presence of h.pilory and gluten sensitivity to start with. Sadly, NHS diagnostic tools are limited due to the budgetary constraints!! It is best to work with a functional medicine practitioner such as nutritional therapist or naturopath to figure out through case history and testing what might be keeping your immune system overreactive. NHS only does gluten allergy and you might need sensitivity test. Lots of people who don't have gluten allergy (Coeliac disease) are very sensitive to gluten that can cause immune activity.
Anyway, I hope that this was not too technical and has answered your question!!
Beautiful explanation thank you~ I’m learning quickly!
Just realised that part of my link is missing.... must have deleted it when writing: ncbi.nlm.nih.gov/pmc/articl...
Sentence after was meant to read: You can start with checking for presence of h.pylori and gluten sensitivity
Your issue is that you typed the word "Check" immediately at the end of your link. Therefore, the link includes that - and ends:
pmc/articles/PMC2773890/Check
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You could edit your post to add a space?
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many thanks.... im technical rookie, will read the links, much appreciated!!
I had a high level of calcium detected in a blood test and small white lumps around my mouth. Various symptoms not unlike those associated with PA (which I have had for 16+ years) after 18 months of tests and scans I had a large tumour removed from one of my parathyroid glands. I had a fractured right shoulder and arm at the time that took 18months to heal and a pain in my left arm, I still cannot use my right arm well and my left arm is still hurting. I put the length of time it took to heal down to the hypoparathyroidism but that was poo pooed by the consultant. Ask your doctor to check your calcium levels in a blood test and go from there. This can be a very serious condition as calcium can be taken from your bones, etc, and deposited around your body including the heart leaving you with weakened bones causing all sorts of problems in the future. So oudh as hard as you can to have this treated urgently. Good luck.
I got diagnosed with hypoparathyroidism a year or so after my B12 issues came to light.(Editing in to add: I don't think one caused the other, it was just going to the Drs about what we thought was hypothyroidism uncovered all my actual issues. lol)
Mine isn't 'total' hypopara in the sense that my parathyroids don't produce PTH at all, but rather 'relative' hypopara in the sense that whilst I produce PTH, it is a steady/unchanged amount that doesn't react to my calcium levels, which is what PTH is supposed to do.
Tbh, my consultant was tossing up between hypopara and a CaSR receptor disorder, but in the end decided the end results were the same and the treatment was the same so just went with hypopara and off we went.
I would certainly recommend following up on your low PTH levels, as, as others have said, left untreated hypopara can do serious damage.
Newly diagnosed with low VitB12
Low B12 after oral tablets 
Low B12 but Negative Parietal Cell Autoantibodies
Ferritin low and supplements 
