Olaparib

[Serefraz]

hello I got the diagnosis in 2015 Brca1. I have been using olaparib for 3 weeks, but ca 125 increased rapidly doktors says its possible early used olaparib please wait one month more. Is there anybody here like me?

[Lindaura]

Dear Sere ,

This is worrying news.

Do you mind giving us a bit more background?

What type of ovarian cancer do you have? Eg: high grade? Low grade? Serous? clear cell?

What has your treatment been since 2015?

What happened recently to get you in the path for receiving Olaparib?

What was your CA-125 before starting Olaparib and what is it now?

Where are you located?

Thanks,

Best wishes,

Laura

[Serefraz in reply to Lindaura]

Dear Lindaura my canser is 3C serous carcinoma and when it came back my ca 125 higher like 750 and ı feel stomache but choterapy was falling to ca 125 until last january ca 125 increase to before 41 after 125. I m from Turkey and there is no olaparib here my doctor wrote the england and astra zeneca gave the olaparib three weeks ago yesterday ı talked my doc abouth ca 125 increase to 500 she says to me we must wait for drug to effect some people like u please wait. So ı’m worry abouth this but ı don’t have any choose not. Thansk for your massege and sorry my english bad

[Lindaura in reply to Serefraz]

Dear Sera,

Thank you for getting back to me with your details.

You are very lucky to be able to receive Olaparib, but it may have been prescribed too soon.

Here in the UK, it is a maintenance drug given after successful treatment with platinum based Chemo.

So at first recurrence, I was put on 6 months of Carboplatin and Caelyx (Doxil), which has brought my CA-125 down from 473 to 17 and when I am finished I will go on to Niraparib, a sister drug to Olaparib.

I am also BRCA1 positive and have high grade serous carcinoma, soon to be in remission, I hope.

I hope you will receive similar successful treatment.

Best wishes,

Laura

[coksd in reply to Serefraz]

This happened to me too my ca 125 went up I am due bloods again soon and I am very bloated think there maybe some fluid as GP suggested but onc nurse said the cancer cell death will be in the blood and can reflect the CA 125 at the start and can take a while to come down I don't know if anyone else has experienced this

[Serefraz in reply to coksd]

Thank you for your answer yesterday ı read my MR there was no cancer area in my stomache but only bloat in there so IHave a pain I hope my ca 125 will fall