Another monoclonal antibody treatment on... - Kidney Transplant

Kidney Transplant

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Another monoclonal antibody treatment on the way?

gustavwind profile image
9 Replies

AstraZeneca has just announced "positive results" from its SUPERNOVA Phase III trial on sipavibart (AZD3152), the updated version of Evusheld:

astrazeneca.com/media-centr...

The press release states that they are in touch with regulatory authorities on developing a pathway for approval, so perhaps it will become available some time in the next few months (perhaps sooner?).

On a related note, has anyone received Pemgarda (that was announced in late March)? My nephrologist - at a prominent major metropolitan medical center with a large transplant center - said that the treatment is currently not available there, due to lack of demand. Has the word not gotten out yet? (For those who are interested, I contacted Invivyd, and doses are indeed available to providers through approved distributors.)

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gustavwind profile image
gustavwind
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9 Replies
Bassetmommer profile image
Bassetmommer

I take a biologic that is a monoclonal antibody. Anyone on Remicade already has this protection.

Transplant2018 profile image
Transplant2018

I'm also having trouble getting Pemgarda.

Ar2D2 profile image
Ar2D2

My doctor wanted me to participate in this study, but there was only a 50% chance I would be getting the actual drug and they required a bunch of morning appts which wasn’t conducive to working full time so I didn’t do it. Hope this becomes availble soon! I had evushield shot when that was effective and it did give me some peace of mind.

I Haven’t heard anywhere near me that has the pemgarda available…

ShyeLoverDoctor profile image
ShyeLoverDoctor

I can’t get pemgarda yet either however it does have a 0.6% chance of life threatening anaphylaxis, black box warning, so I’m not so sure I really want it.

Oceansideup profile image
Oceansideup

Pemgarda also has to be given by IV (from what I read).

Looks like the sipavibart is an injection, if that makes any difference for people…

GardnerADK profile image
GardnerADK

Thanks for sharing this news about another drug to help whole organ transplant recepients and others too. I did my own research online about Pemgarda and the study was not large, like around 686 people and only 33 from the entire study were whole organ transplant recepients. That gives me alot of concern and my spouse with the kidney transplant will not be looking into taking this new drug via infusion every 3 months. I realize it is a personal choice.

DexterLab profile image
DexterLab

I got a big yawn when I was at the transplant center when I mentioned Pemgarda. Not the same as when Evusheld came out. I guess I will wait.

Transplant2018 profile image
Transplant2018

I am anxious to get Pemgarda because I generated no antibodies to my many Covid vaccines. Gratefully my transplant center is now trying to order it for me. But what about all the other transplant patients? I don't understand why centers don't communicate with patients about these mAbs.

Bouvierlover2 profile image
Bouvierlover2

I was in the study and received the drug. Had two doses and absolutely no reaction. Invivd now had a rather rough Pemgarda locator. Medicare does pay for it!!

Also check with your local infusion Centers! Most just need a RX from your physician.

Here is a locator!

locator.infusioncenter.org/

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