Blood test

[kateclowe]

Hi! I was just wondering if anyone had experienced the same blood as me? All my bloods were fairly normal except I carry NMDA receptor antibodies and I just wondered if anyone else had the same kind?

[Jmiller623]

Hi Kate! I am not NMDA positive but can comment based on experience with 2 patients I’ve seen in the past. Anti-NMDA is not super common in lupus but if found, is usually associated with neuropsych lupus. It’s seems that lupus patients with strong positive dsDNA abs cross reacts with an NMDA subunit NR2.

Anti-NMDA is pretty rare in itself and can cause some pretty catastrophic neuro problems - limbic encephalitis being the worst which presents as acute psychosis and flaccidness. Antibodies are also associated with certain types of tumors - teratomas being most common.

Have you had an ANA tested? Why did they test for anti-NMDA? And was there any discussion of testing your cerebral spinal fluid (CSF) for antibody? I attached a link below to an article that discusses anti-NMDA in lupus.

lupus.bmj.com/content/6/1/e...

Not exactly an answer to your questions but hope it helps!

[kateclowe in reply to Jmiller623]

Sorry it took so long to see this! Thank you for all that information.

I haven’t had ANA rested. They tested me for those because of symptoms I was showing (tremors, tiredness, rashes etc...). They did say they wanted to test my CSF but due to the virus at the moment, there’s a delay, understandably.

But thank you so much for all your help. Xx

[Melbourne-Girl]

My understanding of this type of encephalitis is that you must be treated immediately. Sometimes it is with immunosuppressive therapy and occasionally with surgery. It happens in females 80% of the time. Moving forward find the right type of doctor such as a neurologist. Apparently every single persons case is different and if treated early you can get positive results that can take 2-3 months or up to 18 months to fully recover. Good luck with finding the best neurologist to look after you.

Thinking of you and please let us know how you get on. This is not something that I have had personally, although I know people who have had this type of encephalitis which is viral.

My best wishes

M-G xxx

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