complement alternative pathways

[jimbo1605]

At her recent appt at Guys Pooh bear was described by the prof as weird ( something i have know for a long time but nice to have it officially endorsed).

The reason for being weird is that her c3 and c4 dont go up and down together.

So Pooh's c3 is normally low but her c4 is always high - the explanation - complement alternative pathway. She also suffers from bad anemia now - any link ?

She had a load of bloods for c3a, b c5 and others.

Grateful for any insights- impact / risks treatment etc

Still working to get pooh bear back on the pooh sticks again