For the last two years I m taking NEW TRIGL... - Diabetes India
For the last two years I m taking NEW TRIGLUCORED FORTE, please let me know if there is any side effect of this medicine.
New Triglucored Forte consists of 3 fixed drug combination viz., metformin 500 mg, glibenclamide 5 mg and pioglitazone 15 mg.
Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood.
The most common side effects with metformin are nausea, vomiting, gas, bloating, diarrhea and loss of appetite. These symptoms occur in one out of every three patients. These side effects may be severe enough to cause therapy to be discontinued in one out of every 20 patients. These side effects are related to the dose of the medication and may decrease if the dose is reduced.
A serious but rare side effect of metformin is lactic acidosis. Lactic acidosis occurs in one out of every 30,000 patients and is fatal in 50% of cases. The symptoms of lactic acidosis are weakness, trouble breathing, abnormal heartbeats, unusual muscle pain, stomach discomfort, light-headedness and feeling cold. Patients at risk for lactic acidosis include those with reduced function of the kidneys or liver, congestive heart failure, severe acute illnesses, and dehydration.
Glibenclamide (International Nonproprietary Name: INN), also known as glyburide (United States Adopted Name: USAN). Glyburide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glyburide is in a class of medications called sulfonylureas. Glyburide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally.
Common side effects include nausea, heartburn, rashes, low blood sugar, blurred vision and weight gain. Rare but serious side effects include hepatitis, jaundice, and low blood sodium levels (hyponatremia).
Pioglitazone is used with a diet and exercise program and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Pioglitazone is in a class of medications called thiazolidinediones. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.
The most common side effects of pioglitazone alone or in combination with sulfonylureas, metformin, or insulin are upper respiratory tract infection, headache, sinusitis, muscle aches, tooth disorders, hypoglycemia, and sore throat.
In addition, dose related fluid accumulation (edema) can occur especially when combined with insulin. Fluid accumulation can worsen or lead to heart failure. Pioglitazone should not be used in patients with heart disease classified by the New York Heart Association (NYHA) as Class III and IV heart failure or symptomatic heart failure.
Fluid accumulation also may lead to macular edema, resulting in reduced vision. Pioglitazone also can reduce red blood cells.
Pioglitazone has been associated with liver injury. Periodic monitoring of liver-related side effects and liver tests should be conducted in patients taking pioglitazone. Side effects while taking pioglitazone which may be due to liver injury include nausea, vomiting, abdominal pain, fatigue, anorexia (loss of appetite), or dark urine. Liver blood tests also are recommended during pioglitazone therapy.
Pioglitazone may cause ovulation in women who have stopped ovulating if they are premenopausal and insulin resistant. This may lead to pregnancy. For women (but not men) taking pioglitazone, there is an increased risk of bone fractures of the distal bones of the arm and leg. Patients taking pioglitazone should maintain proper bone health.
Sources:--
en.wikipedia.org/wiki/Metfo...
nlm.nih.gov/medlineplus/dru...
medicinenet.com/metformin/a...
en.wikipedia.org/wiki/Glibe...
nlm.nih.gov/medlineplus/dru...
medicinenet.com/glyburide/a...
en.wikipedia.org/wiki/Piogl...
