AAV-GAD Gene Therapy

[JohnP65]

Did anyone hear of AAV-GAD gene therapy? I have a chance to get into a phase 1/2 trial, but information is somewhat limited. The original developing company went bankrupt, and a new company bought the rights to the therapy. The trails are being held at reputable sites like Yale, Columbia , and Cornell. Infusion of the gene is much like DBS. Any information or thoughts would be helpful. Thanks

[park_bear]

A thorough report here:

alzforum.org/therapeutics/a...

[JohnP65 in reply to park_bear]

Interesting article. I do find it odd that the therapy is moving into phase 3 trial, the company goes bankrupt in 2012, and no other company picks up the therapy for 10 years. Is the pipeline for Parkinson’s that slow? I seems there is this therapy, if effective, could be better than DBS.

[park_bear in reply to JohnP65]

If the original sponsor goes bankrupt, the delay for another to pick up the therapy could be anywhere from quick to never. Entirely depending on whether someone else is interested. I was surprised that it did seem to be effective.

[JohnP65 in reply to park_bear]

Exactly! I spoke to a doctor at one of the sites who seemed very positive about the trial. I am curious as to how gene therapy handles disease progression.

[jay_celine in reply to park_bear]

Does this study suggest that taking GABA supplements might produce similar results?

[park_bear in reply to jay_celine]

Interesting question. My searches on the matter were uninformative. I saw one allegation that it does not cross the blood-brain barrier but that was unconfirmed. It is already pretty common in the diet. So, dunno.

[LeharLover62]

Looks really interesting. I wonder, would they let you speak to someone from the original trial?

[gomelgo]

Maybe they had to wait for the bankruptsy proceedings?

[JohnPepper]

i HAVE NEVER NEEDED ANY OTHER THERAPY THAN DOING FAST WLKING!

I have been sympotom-free since 199u7 and am now 89 years old.

HAPPY NEW YEAR

[JohnPepper]

No. Have you tried FAST WALKING? iT IS THE ONLY WAY TO REVERSE PD SYMPTOMS!