choline/citicoline

[Annieartist]

naturalmedicinejournal.com/...

I take a smallish dose but I suspect I need more- anyone using it successfully to make there L-dopa work better/last longer?

[Annieartist]

sorry having trouble with link

naturalmedicinejournal.com/...

[Annieartist]

if you could reduce ldopa or not increase at least I assume it would help avoid dyskinesia

[Buckholt]

instresting report. Thanks

[Gcf51]

I take a product with "Alpha GPC(*)", I am currently finding that cutting back on C/L is reducing my tremor (puzzled). healthunlocked.com/cure-par...

(*) For example, alpha GPC and citicoline have different metabolism processes. As alpha GPC breaks down, acetylcholine is released as a byproduct, where as citicoline serves as a derivative of the same chemical. Alpha GPC may also have a number of interesting side effects that citicoline doesn't have." neurohacker.com/citicoline-....

The product I am taking, also has Uridine which is mentioned in the article as well.

[Heldover101]

I tried it, problem was that it made my levodopa dose time unpredictable, it seemed to dump it all at once and wear off early

[Gcf51 in reply to Heldover101]

Maybe something in that statement applies to me (puzzled 🤔). C/L wasn't helping with my tremor, increasing made it worst and decreasing reduced my tremor.

[1LittleWillow]

I started taking 300 mg CDP choline/citicoline with each dose of my mucuna/carbidopa combo about a week ago. What I noticed immediately was that my on time begins much faster. Without the citicoline, I'm about 1/2 way on in 30 minutes, and fully on in 55 minutes to 1 hour. With citicoline, I have been consistently 100% on in 25 minutes. FYI, I'm tremor dominant, so that's my only super-noticeable symptom as long as I stay on high-dose B1. I also have rigidity, bradykinesia, and dystonia, but with B1 they're too mild and inconsistent to use as an indicator. My tremor, on the other hand, is obvious and easy to use as a gauge.

I've reduced my mucuna and carbidopa doses by about 1/4 all week (started that the second day). My on times have been 1/2 to 1 hour longer, and the going off experience has been much smoother. I was going to share this in a post, but I was going to give it a few more weeks to see if it remains consistent over time before doing so.

[Gcf51 in reply to 1LittleWillow]

I was originally thinking my choice of B1 (Alinamin-F [TTFD-hcl]) was responsible for my reduction in need for C/L. Maybe, it's the Alpha GPC-Uridine. All I can really say is increasing my C/L made my tremor worst and decreasing made tremor better. Repeating link... healthunlocked.com/cure-par...

A little contradiction:      Heldover101 says made unpredictable.      1LittleWillow is indicating consistent improvement.

It would be nice if a few more users of choline/citicoline or Alpha GPC-Uridine would provide their experience...😘

Uridine Monophosphate is a dopamine receptor modulator. Maybe I should up dose of Alpha GPC-Uridine.

Both Alpha-GPC and CDP-Choline are able to increase the dopamine transporter in these brain regions. examine.com/supplements/alp...

[1LittleWillow in reply to Gcf51]

Haha... well, only "consistent improvement" for (I think it was) 6 days at that point. I'm still experimenting. I've had a few weird moments of breakthrough tremors and 2 days where it seemed like I went off after just a few hours, but then it kicked back in and maintained about 80% of my fully on state for several extra hours. I have by no means figured it out yet. After I have a couple of months more experience with it I will share again.

[Annieartist in reply to 1LittleWillow]

likewise every time I think I have a result I’m about to share-suddenly it changes

[LAJ12345]

how does taking citicoline react with anticholinergic meds? Are they the opposites?

[Annieartist in reply to LAJ12345]

couldn’t answer that - can anyone else?

[Boscoejean]

citicoline can cause a reduction in appetite and it did this to my underweight husband with Parkinson's - needless to say he is not taking it at this time- he had been gaining some weight so this was not a step in the right direction and he has lost 4 lb recently which is not weight he can spare