The role of istradefylline in the Parkinson's disease armamentarium

pubmed.ncbi.nlm.nih.gov/370...

Expert opinion: Istradefylline is safe and well tolerated. Its efficacy was pronounced, when patients were on a lower chronic oral levodopa regimen. Levodopa causes a homocysteine elevation, which reflects an impaired methylation potential. As a result, an up regulation of A2A receptor occurs and weakens the efficacy of istradefylline as modulator of dopamine effects on motor behaviour in Parkinson's disease. This is the still hypothetical reason, why clinical trials failed, when patients were on a higher chronic levodopa regimen.A way out of this dilemma is to enable higher dosing of istradefylline and substitution of L-dopa with compounds, which do not influence the methylation capacity. Long term trials may show these levodopa sparing and thus motor complications delaying effects of istradefylline.

[JohnPepper]

Forget about medication, it cannot reverse your symptoms! What does reverse your symptoms is FAST WALKING, every second day!

You will soon se your symptoms get better oif you do it. I have not had any symptoms for many, many years. I now live a NORMAL LIFE at 88, and have had PD since 1992.

[Krist3n in reply to JohnPepper]

John,

i would like to know how you stopped your symptoms? i know you wrote a book, can i purchase it? where?' Chonz123