A study record is now available on the Clinical Trials website for the big (N=330) Ambroxol Phase 3 trial (NCT05778617)

[jeffreyn]

Recruitment Status: Not yet recruiting

Estimated Study Start Date: September 2023

Estimated Study Completion Date: September 2028

Each participant will be taking ambroxol [or placebo] for two years, and it is estimated that it will take two years to recruit 330 PwPs.

Ambroxol to Slow Progression in Parkinson Disease (ASPro-PD):

clinicaltrials.gov/ct2/show...

[limcheeese22]

why would they take so long to complete?? 2028??

[jeffreyn in reply to limcheeese22]

"Each participant will be taking ambroxol [or placebo] for two years, and it is estimated that it will take two years to recruit 330 PwPs."

Plus maybe one year to analyze the data and publish the results?

[Stillstandingstill]

I'm going to register for this one if I can. I have faith in the team, its got a 6 month open label phase so even the placebo group gets to try it, and big pharma is out of the loop so if it proves to be a usable modality the price will not be hiked up. For those that haven't seen the update, I've attached below. Dare we hope?

youtu.be/xdYmaJ-yQy8(Not working as expected?)

[Nickcc]

bloody ridiculous that we have to wait 3 years for a drug that has been available over the counter for years and which phase 2 trials have confirmed have no side effects and help slow PD.

[Stillstandingstill in reply to Nickcc]

It is frustrating, but the doses are much bigger than the previous prescribed use. Hopefully things will move faster if they can recruit quickly. I feel your pain though. Time is brain for those of us waiting and trying to keep in a holding pattern.