Curcumin Update 2023/03/06: I'm trying to... - Cure Parkinson's

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Curcumin Update 2023/03/06

Bolt_Upright profile image
37 Replies

I'm trying to get more organized so any post on a topic will include everything relevant to that topic in one post. So, for instance, future curcumin posts will be updates of this post:

Curcumin Update 2023/03/06

Last Updated: 2023/03/06

Status: In my stack as of 2023/03/05

Dose: 1 gram of Meriva Curcumin twice a day with a fatty meal.

Source: Doctor's Best Curcumin Phytosome with Meriva: $35 for 180 500 mg capsules: amazon.com/dp/B008YDH4HM?ps...

The case for Curcumin:

1 gram of Meriva Curcumin twice a day with a fatty meal for 12 months improved non-motor symptoms, slowed worsening of motor symptoms, and showed a tendency to decrease misfolded α-syn deposits in skin nerves (1).

• A 2022 study evaluated the effects of curcumin supplementation on clinical scales and misfolded, phosphorylated α-synuclein (p-syn) accumulation in skin biopsies in 19 PD patients who received curcumin supplementation for 12 months and 14 PD patients not treated with curcumin (1).

• The patients underwent autonomic (COMPASS-31), motor (MDS-UPDRS and H&Y) and nonmotor (NMSS) questionnaires and skin biopsies to evaluate clinical involvement and p-syn load in skin nerves at the beginning and the end of study (1).

• Curcumin and curcuminoid levels were assayed in plasma and CSF. Supplemented patients showed detectable CSF curcuminoid levels that were lower than those in plasma. They showed:

• A decrease of COMPASS-31 and NMSS scores (1).

• A slight p-syn load decrease versus untreated patients who displayed a worsening of these parameters despite increased levodopa doses (1).

• Note: Simon in The Science of Parkinson's reads this study differently and believes the p-syn load increased for both the treated and untreated, it just increased more in the untreated. I have reached out to the paper's author (1).

• PD patients supplemented with curcumin, despite a stable L-dopa dosage, showed an improvement of nonmotor scales while the worsening of the motor scale was less than expected in the control patients who, by contrast, increased their dosage of L-dopa (1).

• Curcumin chelates iron (4).

• Curcumin inhibits EBV in vitro (8):

• Curcumin Suppresses Proliferation of NPC Cells Positive for EBV (8).

• Curcumin Enhances NPC Cell Apoptosis via Mitochondria- and Death Receptor-Dependent Pathways (8).

• Curcumin Downregulated EBNA1 Expression Levels in NPC Cells Positive for EBV (8).

• Curcumin Reduces Stability and Promotes Proteasomal Degradation of EBNA1 (8).

• Curcumin could inhibit EBV+ HONE1 and HK1-EBV cell proliferation, probably via decreasing EBNA1 expression (8).

• Curcumin Inhibits Replication of EBV in NPC Cells Positive for EBV (8).

• Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). EBNA1 is integral to many EBV functions including gene regulation, extrachromosomal replication, and maintenance of the EBV episomal genome through positive and negative regulation of viral promoters.

• Curcumin Reduces Oxidative Stress (9).

• Curcumin Diminishes the Inflammatory Cascade (9).

• Curcumin Has a Protective Effect on the Integrity of the BBB (9).

• Curcumin Improves Mitochondrial Dysfunction and Calcium Overload (9).

Notes:

• Disease duration seems important for the curcumin supplementation, as PD patients with shorter disease duration presented a better clinical outcome (1).

• PD patients supplemented with curcumin, despite a stable L-dopa dosage, showed an improvement of nonmotor scales while the worsening of the motor scale was less than expected in the control patients who, by contrast, increased their dosage of L-dopa (1)

• Curcumin with Broccoli Seed Extract extends Drosphila Melanogaster lifespan more than either supplement alone (5).

• Is able to cross the blood-brain barrier in the form of its active metabolites when formulated in phospholipids (1).

• Is effective in ameliorating/stabilizing motor and nonmotor symptoms in PD (1).

• Shows a tendency to decrease misfolded α-syn deposits in skin nerves (1).

References:

1. The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study 2022 academic.oup.com/jnen/artic... Vincenzo Donadio, MD, PhD, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italia, via Altura 3, 40139 Bologna, Italy; E-mail: vincenzo.donadio@unibo.it

There are currently no standardized therapies for Parkinson disease (PD). Curcumin shows anti-amyloidogenic properties in vitro and may be a promising treatment for PD. We evaluated the effects of curcumin supplementation on clinical scales and misfolded, phosphorylated α-synuclein (p-syn) accumulation in skin biopsies in 19 PD patients who received curcumin supplementation for 12 months and 14 PD patients to treated with curcumin. The patients underwent autonomic (COMPASS-31), motor (MDS-UPDRS and H&Y) and nonmotor (NMSS) questionnaires and skin biopsies to evaluate clinical involvement and p-syn load in skin nerves at the beginning and the end of study. Curcumin and curcuminoid levels were assayed in plasma and CSF. Supplemented patients showed detectable CSF curcuminoid levels that were lower than those in plasma. They showed a decrease of COMPASS-31 and NMSS scores, and a slight p-syn load decrease versus untreated patients who displayed a worsening of these parameters despite increased levodopa doses. Multiple regression models showed a significant effect of curcumin supplementation in decreasing the worsening of the clinical parameters and p-syn load at after curcumin treatment. These data suggest that curcumin can cross the blood-brain barrier, that it is effective in ameliorating clinical parameters and that it shows a tendency to decrease skin p-syn accumulation in PD patients.

2. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment 2022 cureus.com/articles/96465-a...

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. Dopamine plays a crucial role in motor coordination, memory, and cognition; its decrease in PD leads to dyskinesia, cognitive deficits, and depression. In addition, the formation of alpha-synuclein protein aggregates (Lewy bodies) causes further damage to the CNS. Current treatment options include dopamine precursors, inhibitors of dopamine metabolism, upregulation of autophagy, adenosine A2A antagonists, and surgical intervention as a last resort. A challenge arises from a progressive decrease in treatment efficacy as the disease progresses and this necessitates exploration of adjunctive treatments. Epidemiological studies suggest that the prevalence of PD varies between ethnic groups of Caucasians, Asians, and African Americans. Notably, the prevalence of PD is lower in countries of Southeastern Asia including India. The differences in the diet of various ethnic groups may suggest an origin for this difference in the prevalence of PD. One staple ingredient in traditional Asian cuisine is turmeric. Curcuma longa, popularly known as turmeric, is an orange tuberous rhizome that has been used for centuries in traditional Indian cuisine and traditional medicine. Turmeric contains curcumin, a potent antioxidant that scavenges reactive oxygen species and chelates toxic metals. Curcumin has been proposed to be a neuroprotective agent due to its potent antioxidative properties. Though preliminary studies in animal model systems have suggested a protective effect of curcumin on dopaminergic neurons, the direct benefits of curcumin on the progress of PD remains poorly understood. In this review, we explore the promising use of curcumin as an adjunct to conventional PD treatments in order to enhance treatment and improve outcomes.

3. Curcumin Prevents Aggregation in α-Synuclein by Increasing Reconfiguration Rate 2012 ncbi.nlm.nih.gov/pmc/articl...

α-Synuclein is a protein that is intrinsically disordered in vitro and prone to aggregation, particularly at high temperatures. In this work, we examined the ability of curcumin, a compound found in turmeric, to prevent aggregation of the protein. We found strong binding of curcumin to α-synuclein in the hydrophobic non-amyloid-β component region and complete inhibition of oligomers or fibrils. We also found that the reconfiguration rate within the unfolded protein was significantly increased at high temperatures. We conclude that α-synuclein is prone to aggregation because its reconfiguration rate is slow enough to expose hydrophobic residues on the same time scale that bimolecular association occurs. Curcumin rescues the protein from aggregation by increasing the reconfiguration rate into a faster regime.

4. Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation 2019 nature.com/articles/s41420-...

Iron overload, notably caused by hereditary hemochromatosis, is an excess storage of iron in various organs that causes tissue damage and may promote tumorigenesis. To manage that disorder, free iron depletion can be induced by iron chelators like deferoxamine that are of increasing interest also in the cancer field since iron stock could be a potent target for managing tumorigenesis. Curcumin, a well-known active substance extracted from the turmeric rhizome, destabilizes endoplasmic reticulum, and secondarily lysosomes, thereby increasing mitophagy/autophagy and subsequent apoptosis. Recent findings show that cells treated with curcumin also exhibit a decrease in ferritin, which is consistent with its chemical structure and iron chelating activity. Here we investigated how curcumin influences the intracellular effects of iron overload via Fe-nitriloacetic acid or ferric ammonium citrate loading in Huh-7 cells and explored the consequences in terms of antioxidant activity, autophagy, and apoptotic signal transduction. In experiments with T51B and RL-34 epithelial cells, we have found evidence that curcumin-iron complexation abolishes both curcumin-induced autophagy and apoptosis, together with the tumorigenic action of iron overload.

5. Antioxidant Blend of Curcumin and Broccoli Seed Extract Exhibits Protective Effect on Neurodegeneration and Promotes Drosophila Lifespan 2021 journals.sagepub.com/doi/fu...

Antioxidants and related compounds are anti-inflammatory and exhibit great potential in promoting human health. They are also often considered to be important elements in the process of neurodegeneration. Here we describe a antioxidant blend of Curcumin and Broccoli Seed Extract (BSE). Flies treated with the blend exhibit extended lifespan. RNA-seq analysis of samples from adult fly brains reveals a wide array of new genes with differential expression upon treatment with the blend. Interestingly, abolishing expression of some of the identified genes in dopaminergic (DA) neurons does not affect DA neuron number. Taken together, our findings reveal an antioxidant blend that promotes fly longevity and exhibits protective effect over neurodegeneration, demonstrating the importance of antioxidants in health and pathology.

6. Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis 2017 nature.com/articles/s41598-...

Turmeric has been used as a medicinal herb for thousands of years for treatment of various disorders. Although curcumin is the most studied active constituents of turmeric, accumulating evidence suggests that other components of turmeric have additional anti-inflammatory and anti-tumorigenic properties. Herein, we investigated anti-inflammatory efficacy and associated gene expression alterations of a specific, curcumin preparation containing essential turmeric oils (ETO-curcumin) in comparison to standard curcumin at three specific doses (0, 5, 25 or 50 mg/kg), in an animal model of dextran sodium sulfate (DSS)-induced colitis. The present study showed that both ETO and standard curcumin treatments provided protection against DSS-induced inflammation. However, ETO-curcumin improved disease activity index (DAI) dose-dependently, while the anti-inflammatory efficacy of standard curcumin remained constant, suggesting that ETO-curcumin may provide superior anti-inflammatory efficacy compared to standard curcumin. Gene expression analysis revealed that anti-inflammatory cytokines including IL-10 and IL-11 as well as FOXP3 were upregulated in the colon by ETO-curcumin. Collectively, these findings suggest that the combined treatment of curcumin and essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone, highlighting the anti-inflammatory potential of turmeric.

7. Protective Effects of Indian Spice Curcumin Against Amyloid Beta in Alzheimer’s Disease 2018 ncbi.nlm.nih.gov/pmc/articl...

The purpose of our article is to assess the current understanding of Indian spice ‘Curcumin’ against amyloid-β (Aβ)-induced toxicity in Alzheimer’s disease (AD) pathogenesis. Natural products, such as ginger, curcumin and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, anti-oxidant, anti-arthritis, pro-healing and boosting memory cognitive functions. In the last decade, several groups have designed and synthesized curcumin and its derivatives and extensively tested using cell and mouse models of AD. Recent research on amyloid-β and curcumin has revealed that curcumin prevents amyloid-β aggregation and crosses the blood brain barrier (BBB), reach brain cells and protect neurons from various toxic insults of aging and amyloid-β in humans. Recent research has also reported that curcumin ameliorates cognitive decline and improves synaptic functions in mouse models of AD. Further, recent groups have initiated studies on elderly individuals and patients with AD and the outcome of these studies is currently being assessed. This article highlights the beneficial effects of curcumin on AD. This article also critically assesses the current limitations of curcumin’s bioavailability and urgent need for new formulation to increase its brain levels to treat patients with AD.

8. Curcumin Inhibits Proliferation of Epstein–Barr Virus-Associated Human Nasopharyngeal Carcinoma Cells by Inhibiting EBV Nuclear Antigen 1 Expression 2019 ncbi.nlm.nih.gov/pmc/articl...

This investigation aims to study the effect of curcumin on the proliferation, cycle arrest, and apoptosis of Epstein–Barr virus- (EBV-) positive nasopharyngeal carcinoma (NPC) cells. EBV+ NPC cells were subjected to curcumin treatment. The cell viability was evaluated with the CCK-8. Cell cycle and apoptosis were analyzed by flow cytometry analysis. Expression (protein and mRNA) levels were detected with western blotting and quantitative real-time PCR, respectively. Curcumin efficiently reduced the viability of EBV+ NPC cells. Curcumin induced the cycle arrest of the HONE1 and HK1-EBV cells positive for EBV. Moreover, curcumin treatment promoted the NPC cell apoptosis, via the mitochondria- and death receptor-mediated pathways. Furthermore, curcumin decreased the expression of EBNA1 in the HONE1 and HK1-EBV cells and inhibited the transcriptional level of EBNA1 in the HeLa cells. Curcumin induced EBNA1 degradation via the proteasome-ubiquitin pathway. In addition, curcumin inhibited the proliferation of HONE1 and HK1-EBV cells positive for EBV, probably by decreasing the expression level of EBNA1. In both the HONE1 and HK1-EBV cells, curcumin inhibited the EBV latent and lytic replication. Curcumin could reduce the EBNA1 expression and exert antitumor effects against NPC in vitro.

9. Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia 2022 ncbi.nlm.nih.gov/pmc/articl...

Ischemic stroke is the leading cause of death and disability worldwide, and restoring the blood flow to ischemic brain tissues is currently the main therapeutic strategy. However, reperfusion after brain ischemia leads to excessive reactive oxygen species production, inflammatory cell recruitment, the release of inflammatory mediators, cell death, mitochondrial dysfunction, endoplasmic reticulum stress, and blood–brain barrier damage; these pathological mechanisms will further aggravate brain tissue injury, ultimately affecting the recovery of neurological functions. It has attracted the attention of researchers to develop drugs with multitarget intervention effects for individuals with cerebral ischemia. A large number of studies have established that curcumin plays a significant neuroprotective role in cerebral ischemia via various mechanisms, including antioxidation, anti-inflammation, anti-apoptosis, protection of the blood–brain barrier, and restoration of mitochondrial function and structure, restoring cerebral circulation, reducing infarct volume, improving brain edema, promoting blood–brain barrier repair, and improving the neurological functions. Therefore, summarizing the results from the latest literature and identifying the potential mechanisms of action of curcumin in cerebral ischemia will serve as a basis and guidance for the clinical applications of curcumin in the future.

10. Evaluation of curcumin as add-on therapy in patients with Parkinson's disease: A pilot randomized, triple-blind, placebo-controlled trial 2022 sciencedirect.com/science/a...

• Idiopathic PD patients aged ≥30≥ 30 whose symptoms were under control were included in this pilot, randomized, triple-blind, placebo-controlled, add-on trial. Eligible patients were randomly assigned to either the curcumin (n = 30, 80 mg/day) or placebo (n = 30) groups and were followed for nine months. Primary outcomes were the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and Parkinson's Disease Questionnaire (PDQ-39). These variables, along with demographic data, drug history, and possible side effects of curcumin, were gathered at the beginning of the study and every three months. A mixed effects model was used to compare the group-by-time interaction, followed by post hoc analysis.

• Although the mean MDS-UPDRS and PDQ-39 scores were not significantly different between the curcumin and placebo groups at any time points, MDS-UPDRS part III (P = 0.04) showed a significant difference in its overall trend between the study groups. However, post hoc analysis failed to spot this difference at study time points. The most common side effects of curcumin were nausea and vomiting (P = 0.25) and gastroesophageal reflux (P = 0.42).

• While curcumin is a well-tolerated natural compound, this trial was unsuccessful in showing its efficacy in quality of life and clinical symptoms of PD patients.

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Bolt_Upright
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37 Replies
Fabnus profile image
Fabnus

Nice job bolt. I read recently that when combined with ginkgo, it goes through the BBB easier.

pubmed.ncbi.nlm.nih.gov/368...

Bolt_Upright profile image
Bolt_Upright in reply to Fabnus

Interesting! Thanks!

park_bear profile image
park_bear

Well done!

chartist profile image
chartist

That's gonna be a lot of organizing, Bolt!

I remember testing Meriva and Tertahydrocurcuminoids about 10 years ago. It was a fairly short test for both as it turned out I was allergic to curcumin products.

Art

reedboat2 profile image
reedboat2

fantastic job Bolt, thank you. I’d been taking CuraPro 750’s and switched to the product mentioned, as it is more economical.

JayPwP profile image
JayPwP

How does theracurmin fare against the meriva product listed above?

JayPwP profile image
JayPwP

I am currently taking Organic India Turmeric Formula 500mg twice a day. I then came across an old post mentioning Theracurmin and I was about to order from Vitacost.

Should I order the one mentioned in the above post by Bolt?

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

It is so hard to know what to take. Some articles say curcumin is not very bioavailable and does not cross the BBB, others say curcumin with lipids does cross the BBB.

I mostly know that they used Mireva in this one study, but I also know Mireva is made in Italy and they researchers were Italian so that may be why they used Mireva. Longvida curcumin might have worked as well or better.

BCM-95 curcumin sounds good too. It has the tumerone oils. I have some of that.

So for now I am using Mireva because it is reasonably priced and was used in the study. I am keeping my eyes on the research and may switch if I see other research.

JayPwP profile image
JayPwP in reply to Bolt_Upright

Thanks for the response Bolt.

JayPwP profile image
JayPwP in reply to Bolt_Upright

Any thoughts about the Vitacost Synergy curcumin with meriva?

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

Just that it is $25 for 60 500 mg capsules and Doctor's Best is $30 for 180 500 mg capsules.

JayPwP profile image
JayPwP in reply to Bolt_Upright

Bolt,

Vitacost Synergy curcumin with meriva is $29.99 for 120 capsules, but it contains Soy lecithin, hence I requested for inputs from the members here 😊

JayPwP profile image
JayPwP in reply to JayPwP

Hello friends, Bolt_Upright

No comments?

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

Apologies. I am very cost conscious. Doctor's Best is $30 for 180 500 mg capsules. Vitacost is $30 for 120 500 mg capsules? (Amazon shows Vitacost as $25 for 60 500 mg capsules) amazon.com/Vitacost-Turmeri...

Even at $30 for 120 500 mg capsules, Vitacost still costs a third more than Doctor's Best and I imagine they are the same quality.

JayPwP profile image
JayPwP in reply to Bolt_Upright

Thanks Bolt_Upright

I am more concerned about the Soy lecithin rather than the cost, but point taken.

BTW,

Source: Doctor's Best Curcumin Phytosome with Meriva: $35 for 180 500 mg capsules:

amazon.com/dp/B008YDH4HM?ps...

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

Ah, they always fool me with that subscribe price.

I don't see Soy lecithin in Doctor's Best. Soy lecithin is something you want in your supplement?

JayPwP profile image
JayPwP in reply to Bolt_Upright

I don't want Soy lecithin hence I have ordered Doctor's Best. Delivery expected by 23 March

JayPwP profile image
JayPwP in reply to Bolt_Upright

According to this article, both Longvida and Meriva use Soy Lecithin

Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

ncbi.nlm.nih.gov/pmc/articl...

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

I noticed Soy Lecithin was in my chocolate bar the other day. Should I be concerned? I have not looked into Soy Lecithin.

JayPwP profile image
JayPwP in reply to Bolt_Upright

Doctor's Best has Sunflower Lecithin 😊

JayPwP profile image
JayPwP in reply to Bolt_Upright

And according to this article here:

patrickholford.com/advice/h...

However, is Theracurmin the most bio-available? Before looking at a comparison it is worth pointing out that these different supplements of curcumin are not 100% curcumin. For example, Longvida and Meriva are 80% phospholipids bound to 20% curcumin. So, if you were taking 1,000mg of Longvida you’d be getting 200mg of curcumin. Similarly, 10% of the Theracurmin is curcumin. So, 300mg of Theracurmin gives you 30mg of curcumin. So, in the above graph, 300mg of Theracurmin, giving 30mg of curcumin, is absorbed hundreds of times better than 50mg of curcumin powder.

The graph below shows a comparison of the different most bio-available forms of curcumin. As you can see Theracurmin is not only the one that most raises blood levels of curcumin but it also keeps those levels raised for at least 4, if not 8 hours.

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

Yes, this is very complicated. Right now I am mixing my BCM-95 and Meriva fairly randomly until I get through the BCM-95, then I will stick with the Meriva until I learn something definitively different. I don't actually believe for sure the Meriva is superior, but it is reasonably priced and is what they used in the study.

Boscoejean profile image
Boscoejean

nano-curcumin supposedly more bioavailable

frontiersin.org/articles/10...

Bolt_Upright profile image
Bolt_Upright in reply to Boscoejean

Wow, they actually sell Nano Curcumin too. Something to look into. Thanks!

Zella23 profile image
Zella23

Great post Bolt! It used to be one in our stack of supplements and is in a joint preparation we both take. I m going to read through again and look up some of the suggestions. Many thanks for posting, and the research.

Shorebird profile image
Shorebird

Bolt, thank you so much! My husband just started the Mireva product yesterday based on your earlier posts - but this is a wonderful summary of the data. We appreciate all you do! 🙏🏼

Raphaekg profile image
Raphaekg

Another citation for your list, This clinical trial used Sina Curcumin®, curcumin nanomicelles in soft gelatin capsules, 80 mg/daily as daily treatment . It is manufactured in Iran.

sciencedirect.com/science/a...

Evaluation of curcumin as add-on therapy in patients with Parkinson's disease: A pilot randomized, triple-blind, placebo-controlled trial

Hamidreza Ghodsi 1, Hamid Reza Rahimi 2, Seyedeh Mehrnaz Aghili 3, Amin Saberi 4, Ali Shoeibi 5

PMID: 35636380 DOI: 10.1016/j.clineuro.2022.107300

Abstract

Background and objective: Preclinical studies suggest that curcumin might be a potential neuroprotective agent in Parkinson's disease (PD). This clinical trial aimed to evaluate the efficacy of adding nanomicelle curcumin on improving the motor and non-motor symptoms of PD patients and their quality of life.

Material and methods: Idiopathic PD patients aged ≥30≥ 30 whose symptoms were under control were included in this pilot, randomized, triple-blind, placebo-controlled, add-on trial. Eligible patients were randomly assigned to either the curcumin (n = 30, 80 mg/day) or placebo (n = 30) groups and were followed for nine months. Primary outcomes were the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and Parkinson's Disease Questionnaire (PDQ-39). These variables, along with demographic data, drug history, and possible side effects of curcumin, were gathered at the beginning of the study and every three months. A mixed effects model was used to compare the group-by-time interaction, followed by post hoc analysis.

Results: Although the mean MDS-UPDRS and PDQ-39 scores were not significantly different between the curcumin and placebo groups at any time points, MDS-UPDRS part III (P = 0.04) showed a significant difference in its overall trend between the study groups. However, post hoc analysis failed to spot this difference at study time points. The most common side effects of curcumin were nausea and vomiting (P = 0.25) and gastroesophageal reflux (P = 0.42).

Conclusion: While curcumin is a well-tolerated natural compound, this trial was unsuccessful in showing its efficacy in quality of life and clinical symptoms of PD patients.

Bolt_Upright profile image
Bolt_Upright in reply to Raphaekg

Thanks, I added that report to my references. They only used 80 milligrams once a day in their study. The Mireva trial used 1 gram twice a day. I don't know if the Mireva works, just pointing out the huge difference in dosing.

Ropadopa profile image
Ropadopa

where do we find the curcumin/broccoli combo pills? I have taken Dr Terry’s brain line of curcumin supplements.

Bolt_Upright profile image
Bolt_Upright in reply to Ropadopa

That broccoli curcumin combo study was done on a fly. I just eat broccoli sprouts myself. A lot cheaper.

I did find this: BrocElite Professional with Curcumin - 60 caps but it costs $90 for a 30 day supply. I would never pay that. mara-labs.com/products/broc...

Ropadopa profile image
Ropadopa in reply to Bolt_Upright

thanks for sharing this information and for sharing your experiences with us

SilentEchoes profile image
SilentEchoes

*This: Curcumin Improves Mitochondrial Dysfunction and Calcium Overload

Fumaniron profile image
Fumaniron

Thank you, as always

Rufous2 profile image
Rufous2

Hi Bolt, I thought about you when I ran across this paper. It's not about Curcumin, but I thought it might interest you because Curcumin's such a powerful anti-inflammatory; movementdisorders.onlinelib...

Bolt_Upright profile image
Bolt_Upright in reply to Rufous2

Interesting. Thanks for sharing.

Esperanto profile image
Esperanto

Instead of buying curcumin 💊 supplement, you can also grow turmeric as a root or buy it as a powdered herb that also contains curcumin and incorporate it into your daily meals. Add a pinch of turmeric powder to your curries, stir-fries, soups, or smoothies for an extra flavor dimension and a touch of health.

Besides curcumin, turmeric also contains other compounds that contribute to its taste, aroma, and potential health benefits. Some of these compounds include volatile oils like tumerone, atlantone, and zingiberene; other curcuminoids like demethoxycurcumin and bisdemethoxycurcumin; various vitamins and minerals including vitamin C, vitamin E, vitamin K, calcium, iron, potassium, and magnesium; dietary fiber.

To enhance absorption, you can combine turmeric with black pepper and healthy fats such as olive oil or coconut oil. This can increase the bioavailability of curcumin. Here are some recipes for inspiration:

Turmeric Infusion

Turmeric infusion is a comforting and healthy hot beverage. To prepare it, bring a cup of water to a boil in a saucepan. Add a teaspoon of turmeric powder and let it simmer for 10 minutes. You can also add other spices like ginger, cinnamon, or black pepper for added flavor. Strain the infusion and add honey or lemon according to your taste. Enjoy this warm and soothing drink at any time of the day.

Turmeric and Yogurt Chicken

Marinate chicken pieces in a mixture of plain yogurt, turmeric, paprika, garlic, salt, and pepper for at least 2 hours. Bake them in the oven at 180°C for 25 minutes, flipping them halfway through cooking. Serve with basmati rice and fresh coriander.

Turmeric and Coconut Milk Lentil Soup

Sauté finely chopped onion in a saucepan with a little olive oil. Add 200g of rinsed red lentils, a teaspoon of turmeric, a pinch of cumin, salt, and pepper. Cover with water and bring to a boil. Simmer for 20 minutes until the lentils are tender. Blend the soup with 200ml of coconut milk. Serve with toasted bread or naan.

Turmeric Sautéed Rice with Vegetables

Cook white rice according to package instructions. Drain and set aside. In a wok, heat a little sesame oil. Stir-fry your choice of vegetables, cut into small pieces (carrot, bell pepper, broccoli, mushroom, etc.). Add a tablespoon of soy sauce, a teaspoon of turmeric, salt, and pepper. Add the cooked rice and mix well. Serve with crushed peanuts or sesame seeds.

Turmeric and Orange Smoothie

In a blender, blend the juice of two oranges, one peeled banana, a teaspoon of turmeric, a pinch of ground ginger, and a few ice cubes. Enjoy this vitamin-rich smoothie for breakfast or as a snack.

Turmeric Hummus

In a food processor, combine 400g of drained chickpeas, the juice of one lemon, two tablespoons of tahini (sesame paste), two peeled garlic cloves, a teaspoon of turmeric, salt, and pepper. Blend until smooth and creamy. Add a little water if needed. Serve with raw vegetables or crackers.

Turmeric and Cheese Quinoa Patties

Cook 150g of quinoa according to package instructions. Drain and let it cool. In a bowl, mix the cooked quinoa with one beaten egg, 100g of grated cheese, two tablespoons of flour, a teaspoon of turmeric, salt, and pepper. Form patties with your hands and brown them in an oiled pan for a few minutes on each side. Serve with a green salad or plain yogurt.

Turmeric and Dried Fruit Cake

Preheat the oven to 180°C. In a bowl, whisk 3 eggs with 150g of brown sugar. Add 150g of melted butter, 200g of flour, a packet of baking powder, a teaspoon of turmeric, and a pinch of salt. Mix well. Incorporate 100g of chopped dried fruits (apricots, raisins, cranberries...). Pour the batter into a greased and floured cake pan. Bake for about 35 minutes. Allow to cool before removing from the pan and slicing.

Roasted Cauliflower Salad with Turmeric and Walnuts

Preheat the oven to 200°C. Cut a cauliflower into small florets. In a bowl, mix two tablespoons of olive oil, a teaspoon of turmeric, salt, and pepper. Brush the cauliflower florets with this mixture and place them on a baking sheet lined with parchment paper. Bake for 25 minutes, flipping them halfway through cooking. Let cool. In a salad bowl, mix the roasted cauliflower with arugula, crushed walnuts, and a vinaigrette dressing.

Turmeric Tofu

Cut tofu into cubes and sauté it in a pan with olive oil, turmeric, soy sauce, and maple syrup. Serve this golden and flavorful tofu with sautéed vegetables or rice for a delicious vegetarian meal.

Turmeric Omelette

Add 1/2 teaspoon of turmeric to your beaten eggs before cooking them to prepare a colorful and spicy omelette. You can also add other vegetables like bell peppers, onions, or spinach for more flavors.

Turmeric Pasta

Sauté vegetables like zucchini and bell peppers in a pan with garlic, olive oil, and turmeric. Add cooked pasta and mix well. This will give you a colorful and flavorful pasta dish.

Turmeric Hot Chocolate

Add a pinch of turmeric to your cup of hot chocolate for a comforting drink with a spicy twist. Turmeric pairs well with dark chocolate and adds a warm flavor to this classic beverage.

Curcumin Turmeric
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Ob6842 in reply to Esperanto

Another easy option is to slice fresh organic Tumeric and ginger and pour very hot water (not boiling water) into a saucepan, and let them seep about 30 minutes. Cool down, strain, and add a little of this liquid to any beverage. I add it to cold green tea. Double healthy!

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