SHOCKING video upends everything we thought we knew about PD!

[PDWarrior1900]

From the "Silver Bullet YouTube Channel"

I've watched portions of this several times!

This doctor has a completely DIFFERENT take on PD!

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youtu.be/k703Shlgkhw(Not working as expected?)

[WinnieThePoo]

Yeah, don't hold your breath

[PDWarrior1900 in reply to WinnieThePoo]

that's what I like about you Winnie.... always so positive! LOL

[MBAnderson in reply to PDWarrior1900]

Yeah, don't hold your breath.

[JayPwP]

I think the YouTube channel is owned by Michel0220

[PDWarrior1900]

... another one! LOL

[kaypeeoh]

So....the problem is excess dopamine, not a deficiency. And a drug to stop tyrosine hydroxylase could lower the excess dopamine. But what makes the excess dopamine toxic? I can kinda see an answer; If there is too much of a compound it can crowd the receptor but not activate it. So what causes excess dopamine in the first place????

[PDWarrior1900 in reply to kaypeeoh]

well when i watch/listen to these videos i'm in bed falling to sleep ... so i only "half-get" what they're saying before i get zzzzzzzzzzzz's ... but i found the good doctor to be very sincere (really, i do) ...he only needs $10 million for his clinical trial... i'll put up half if you'll put up the other half... lol

[kaypeeoh in reply to PDWarrior1900]

I'm retired and on Social Security. No money available to help. You're on your own, dude.

[LAJ12345 in reply to kaypeeoh]

is xs dopamine caused by it not being broken down fast enough?

[Beanie57 in reply to kaypeeoh]

Groundhog day. Re Diabetes - Well years ago when I started learning Diabetes they use to say Pancreas cells have died - so now need to replace insulin because your not making enough now total reversal youtube.com/watch?v=r0d5lJz...(Not working as expected?). So I think he may be on to something

[WinnieThePoo]

It's worth observing the good doctor owns a patent...

[Bolt_Upright in reply to WinnieThePoo]

That is a good point, but to be fair, patents not only protect earnings, they also protect control and self determination.

[WinnieThePoo in reply to Bolt_Upright]

Sure. It's just that the research he wants someone else to fund, is into a molecule which he will be able to commercially exploit if his theories are proven. I don't think it's going to deliver anything. I'm far more worried about what has happened to Peter Tass's glove trial

[Bolt_Upright in reply to WinnieThePoo]

Something happened to Peter Tass's glove trial?

[WinnieThePoo in reply to Bolt_Upright]

Stanford have terminated it with no reason given

clinicaltrials.gov/ct2/show...

[IdaOphelia in reply to WinnieThePoo]

I think that when you look at "Last Update Submitted that Met QC Criteria: December 22, 2022", that is only an indication that the entry itself into that element - Recruitment Status: (which is the thing that has been updated) - has been correctly populated, and that submitted changes to that RECORD are consistent with National Library of Medicine (NLM) quality control (QC) review criteria (such as errors, deficiencies, or inconsistencies). Specifically, it is only a review of the data entry comment (Terminated...) that has been QC'd/accepted as being consistent with the NLM QC criteria.

If so, it seems to me that the study has been terminated with no intention of restarting. Hopefully there is a good reason for this.

See glossary terms here: clinicaltrials.gov/ct2/abou...

"Last update submitted that met QC criteria"

"Quality control (QC) review"

"Recruitment status terminated"

Perhaps it has been replaced with this one - NCT05504902?

[Bolt_Upright in reply to WinnieThePoo]

From Twitter:

Feb 15 Replying to @peter_tass and @StanfordNsurg

Hello Dr. Tass. Since the last study was canceled, there doesn’t seem to be any additional information about what’s happening with the gloves. When will there be an update?

Peter A. Tass, MD, PhD @peter_tass Feb 15 Replying to @Team_PGN and @StanfordNsurg

We will start several studies this year. They will be announced in advance. Thank you

PGN @Team_PGN

Feb 15 Replying to @peter_tass

Are you enrolling study participants for the glove treatment? How can someone become a study participant?·

Feb 15 Replying to @secretsea18

Please contact [e-mail] . We are currently setting up a process that enables us to properly reach out to inquiries. This will be up and running soon. Thank you!

[IdaOphelia in reply to Bolt_Upright]

Next Question- I am scheduled for DBS in 3 weeks -thoughts?

[WinnieThePoo in reply to Bolt_Upright]

Thanks. Interesting update. Let's hope they drive this along

[Bolt_Upright in reply to Bolt_Upright]

Here is the link to the Twitter chain: twitter.com/peter_tass/stat...

[PDWarrior1900 in reply to Bolt_Upright]

great post, bolt! thanks

[HekateMoon in reply to WinnieThePoo]

Bless them...

[Boscoejean]

I plan to communicate with the doctor to see how things are going

[Michel0220 in reply to Boscoejean]

Hi Boscoejean - as far as I am aware he is still working on putting in place the financing for setting up a full medical trial. Those things are not easy and take time, and I am hoping he will be successful.

[Boscoejean in reply to Michel0220]

I hope he can find the funding -- it seems like a very difficult task.

[PixelPaul]

if nothing else it’s at least an interesting theory. It’s not as if conventional thinking has produced much of anything in the last 50+ years.

[JohnPepper]

I have had Pd symptoms since 1994. at that time I started doing FAST WALKING and my symptoms only get worse when I stop doing the fast walking. Wjat do you make of that?

[Esperanto in reply to JohnPepper]

That you were very lucky and that you deserve a statue!

Lucky because you have a form of PD for which you have found the ideal treatment, just like Scott Hanley with whom he came to the newspaper this week.

A statue because you have promoted this form of exercise with great patience despite all the taunt. You were probably one of the first to see the importance of exercise for PD as crucial at all. It should give you great satisfaction that that is now also confirmed by science.

Unfortunately, it is not ‘the’ solution for everyone with PD. The clinical picture is too diverse and complex for that. But for many of us, it can perhaps help limit the damage. Merci! 🍀

[JohnPepper in reply to Esperanto]

Thanks for your kind words. There will never be a fix-all solution to Pd, but knowing there is something that many of us can do, must give others hope!

[JayPwP in reply to Esperanto]

Completely agree

[billybobAK]

I have been taking a ldopa holiday for quite a while . i've been on ldopa for about 13-14 years now. I feel good that day, voice near normal, more engaged socially, clear headed in the afternoon, wirth the biggest plus being NONE OF THE DREADED DYSKENISIA. However can't walk well outside the indoor environment and i need the ldopa to exercise.

[LeharLover62]

Really interesting! I did some digging on intracellular dopamine and VMAT2 disfunction as mentioned in the doctor’s presentation. I found a Chinese study on a supplement called Gastrodin (tian ma) which may stimulate neuroregeneration: assets.researchsquare.com/f...

It was a study done on MPTP Parkinson’s induced mice:

“It is well known that VMAT2 transporters located on vesicles play an important role in maintaining the balance of DA homeostasis via uptake of cytoplasmic DA into vesicles for storage[26]. Therefore, the expression levels of VMAT2 mRNA and protein were tested by qPCR and Western blot. As shown in Fig. 3C and 3D, MPTP treatment signicantly decreased the expression levels of VMAT2 mRNA and protein, whereas that markedly increased in response to GTD (Gastrodin) These results indicated that GTD could activate VMAT2 to promote DA uptake into vesicles for maintaining DA homeostasis.”

[PDWarrior1900 in reply to LeharLover62]

thanks for the good post - i'll check that

[robinson621]

I think he is onto something, i wish i could find a good openminded neurologist who is knowledgeable about PD and not stuck on standard PD treatments

[JohnPepper]

Good Morning

I have had PD since 1992. In 1994 my wife persuaded me to join her at RUN/WALK for life. Which I did.

Within two years my PD symptoms had got so much better that I thought I was cured, but when I stopped the Fast Walking my symptoms slowly returned.

It has since been proven that Fast Walking produces GDNF in the brain and that reverses the symptoms until we appear to be cured, but we are not.

If I stop the fast walking my symptoms return.

This was proven in the Mayo Clinic Study in 2019.

Why are patients not told about this?

It has worked for me for over 30 years. I am now 88.

Comments please?

John Pepper

[gomelgo in reply to JohnPepper]

When I saw your video, I went immediately back to walking along the river. I was starting to actually do some jogging, and then winter came. My eyes tear up a lot in the cold, so I had stopped. But I could not agree more that fast walking helps. Also, I wish these things were not so expensive, I would get them too. ANd I forget their name. They are round tubes with small weights inside, and a grip that helps with arm swing. Anyone remember what they are called?

[Ashti in reply to gomelgo]

Smovey rings!

A pair of green Smovey rings

[JohnPepper in reply to gomelgo]

Hi. Not wanting to NAG you, jogging does nothing for you! YOU MUST WALK AS FAST AS YOU POSSIBLY CAN!

What things are you talking about?

[gomelgo in reply to JohnPepper]

tell me why you think it's different walking or jogging? I found the rings. Here smoveyhealth.com/

[JohnPepper in reply to gomelgo]

Many studies have bee carried out on Fast Walking and it has been proven beyond any doubt , which repairs the damaged brain cells fast walking produces GDNF inn the brain cells. You are free to do whatever you want to do. All exercise is good for our health, but if your goal is to reverse your PD then FAST WALKING is the only way known tro achieve this goal. See Mayo Clinic report. 2019

[PDWarrior1900 in reply to JohnPepper]

that's interesting John, but there are verifiable reports that the KETO diet has also worked for many with PD... plus numerous other testimonials about various therapies/ supplements... no 'cures' of course...

[JohnPepper in reply to PDWarrior1900]

There has been at least one study done on fast walking, and that was by the MAYO Clinic, back in 2019.

They found that the brain produces GDNF when doing the fast walking. As you know, it is the shortage of GDNF in the brain that causes PD. It was found to produce over 5000 mg of GDNF, but stops producing it after one hour.

No other exercise was found to do that!

Walking fast is not natural, we would normally run if I was in a hurry. I think the brain assumes that I must be in danger and produces the GDNF to repair any brain cells. That I my assumption, and it works!

[PDWarrior1900 in reply to JohnPepper]

88, wow! Keep up the great work!

[JohnPepper in reply to PDWarrior1900]

It is becoming more and more difficult, but in between bouts of other health problems I am out there, walking as fast as I can, which is not that fast now! I feel much better after a walk, it loosens me up and helps to keep me mobile.

[PDWarrior1900 in reply to JohnPepper]

take a minute to get INSPIRED! Watch this '97' ... year YOUNG lady perform GYMNASTICS that I couldn't do at 20 years old!

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youtu.be/H8Pgfu25jrE(Not working as expected?)

[gomelgo]

so did you actually stop having tremor from the fast walking?

[JohnPepper in reply to gomelgo]

NO! I was able to concentrate on what I was trying to do and am able to overcome the tremor, for that particular need.

If I concentrate hard when writing, I can write without any tremor, but it is very slow.

The moment I try to go faster the tremor takes ove and it is all squiggly.

Just concentrate very hard!