I just got this email from the Michael J. Fox Foundation
"A vaccine to slow or stop Parkinson’s – which received early funding from The Michael J. Fox Foundation – is safe and induces antibodies, reports a recent paper. Researchers recently completed a randomized first-in-human study of UB-312, a vaccine they hope will prove effective against Parkinson’s. This phase of the study, completed by Vaxxinity as part of an ongoing clinical trial, examined the effectiveness and safety of the vaccine in blocking toxic build-ups of the alpha-synuclein protein – a pathological hallmark of Parkinson’s and a priority target for drug development."
I sure hope this proves to be successful, but I am struck by this sentence:
"With these results, researchers hope this vaccine can reduce or even block alpha-synuclein build-ups and prevent neurodegeneration (the cause of motor degeneration and non-motor symptoms)."
I am skeptical about the assertion/assumption that alpha-synuclein build up is the cause of motor degeneration and non-motor symptoms. A similar assertion/assumption regarding the build up of beta amyloid appears to have led to decades of futile Alzheimer’s Disease research.
Hi Jim . . . it is my understanding that it is conjectured that the cause of Parkinsons is initiated by the aberrant misfolded alpha synuclein proteins. Hopefully, all the money spent on this theory is because the blind have been following the blind!!
Correct. But it has also been conjunctured that Alzheimer’s is initiated by the aberrant misfolded beta amyloid proteins. As I understand it, various Alzheimer’s drugs have been designed to remove or prevent beta amyloid accumulations, but have not affected the underlying disease. A recent post on this site suggests that the initial claim that misfolded beta amyloid proteins cause Alzheimer’s was fraudulent. It does seem to be the blind leading the blind. Ugh.
Check out A C Immune who recently acquired the PD Vaccine portfolio from AFFRIS. Tracer capability now measures alpha-synuclien...msg. me if you can update,thanks
PD is often lumped in with MS; Both are brain dysfunctions. Autohemotherapy (AHT) is an old treatment. It was popular until the advent of antibiotics in the 1940's. But it also treated conditions like MS. I was dx'd with MS years ago. After reading about AHT I tried it on myself. Ultimately the MS was cured. Now that I have PD I'm trying it again. AHT is a very simple treatment; With 40 years of medical experience it's easy for me to do. Vaccines produce antibodies that treat disease. AHT produces antibodies that stop MS. I wonder if AHT can treat PD. Eventually I'll talk to my neuro about this. But for now I'll continue with monthly AHT treatments.
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