Before my diagnosis I always had Low level of Vitamin D (like many of Pwpd) and High level of PTH (Parathyroid hormone) but normal calcium level. This study is from 2018 but Calcium concept has been intriguing me for years specially after I was diagnosed with Idiopathic Parkinson's disease.
Insights from a new study — by the University of Cambridge in the United Kingdom — about the role of calcium in brain cells’ signaling mechanisms brings us closer to understanding the causes of Parkinson’s disease.
medicalnewstoday.com/articl...
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
nature.com/articles/s41467-...
Calcium levels rise inside brain cells when they need to release neurotransmitters - such as releasing dopamine to send messages to co-ordinate movement. This study suggests that when calcium levels increase, alpha-synuclein is activated and attaches to packages of neurotransmitters (called 'synaptic vesicles') which helps them to be released. For everything to work properly there needs to be the right balance of calcium and alpha-synuclein in the cell. According to this study, when this balance is disturbed and there is too much of one or the other, alpha-synuclein starts to form toxic clumps that damage the cell.
Parkinson’s disease: don’t mess with calcium