Blastocystis hominis (BH) and IL-17: I think I found something?

[Bolt_Upright]

chartist healthunlocked.com/cure-par...

JANVAN healthunlocked.com/cure-par...

You all have both posted about IL-17 and its relationship to PD. Well IL-17 is also related to Hashimoto's. And Hashimoto's is also related to PD. And frozen shoulder is related to PD and Hashimoto's.

And... IL-17 can be caused by a parasite called Blastocystis hominis. And... this parasite can be killed.

Improving Hashimoto’s thyroiditis by eradicating Blastocystis hominis: Relation to IL-17 Feb 2021 journals.sagepub.com/doi/10...

Background:

Hashimoto’s thyroiditis (HT) is a common autoimmune disorder that causes significant morbidity. Interleukin (IL)-17 was identified as a major contributing factor in the pathogenesis of HT. Blastocystis hominis (BH) is a very common infection and has been shown to be associated with several diseases. Our aim was to determine serum IL-17 level in HT patients with and without BH infection and the effect of eradicating BH in patients with HT.

Methods:

A prospective cohort study was conducted on 20 HT patients not infected with BH (group I), 20 HT patients infected with BH (group II), and 20 healthy patients (group III). Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibodies (anti-TPO), and IL-17 were performed by ELISA method and were repeated in group II after 6 weeks of eradication of BH.

Results:

Patients with HT showed a significantly higher serum IL-17 compared with controls. IL-17 was significantly higher in HT patients infected with BH compared with HT patients not BH infected (mean 6.93 ± 2.83 pg/ml versus 3.25 ± 1.55 pg/ml, p = 0.003). After BH eradication TSH, anti-TPO, and IL-17 were significantly decreased (mean 14.76 ± 11.11 µIU/ml versus 9.39 ± 7.11 µIU/ml, p < 0.001; mean 308 ± 175.6 IU/ml versus 295.4 ± 167.1 IU/ml, p = 0.006; and mean 6.93 ± 2.83 pg/ml versus 6.45 ± 2.48 pg/ml, p < 0.001), respectively. Multivariate analysis after treating BH infection showed that IL-17 was significantly negatively correlated with FT3 (adjusted p = 0.002) and significantly positively correlated with anti-TPO (adjusted p = 0.045).

Conclusion:

Treatment of BH infection ameliorates HT through reduction in IL-17, anti-TPO, and TSH.

Clinical trial registration number: PACTR201909495111649

Blastocystis hominis (BH) is the most common intestinal protozoan isolated in humans. Although this parasite remains asymptomatic in most of the cases, yet it can function as an opportunistic pathogen and cause gastrointestinal disorders in immunocompromised patients. BH infection is associated with various diseases and it has been demonstrated that BH has the ability to modulate immune response.5

Th17 cells and their hallmark cytokine IL-17 were identified as major contributing factors in the pathogenesis of HT. Only a few studies addressed the relation between IL-17 and HT. It was interesting to study the level of IL-17 in HT patients with and without BH infection and observe the effect of eradication of BH on IL-17 level and the course of HT.

In group II, BH infection was treated using 500 mg nanazoxid 3 tablets/day for 3 days then clinical examination and laboratory investigations were repeated after 6 weeks of eradication of BH infection.

Results of anti-TPO antibodies showed that it was significantly higher in groups I and II than in the control group (mean 436.6 ± 286.6 IU/ml versus 17.65 ± 5.66 IU/ml and mean 308.0 ± 175.6 IU/ml versus 17.65 ± 5.66 IU/ml, respectively). There was no significant difference in anti-TPO antibodies between groups I and II.

All patients with HT exhibited higher levels of serum IL-17 compared with normal patients. In comparison with the control group, serum IL-17 was significantly higher in patients with HT without BH infection (Group I) (mean 3.25 ± 1.55 pg/ml versus 1.41 ± 0.88 pg/ml, p = 0.002), as well as in patients with HT infected with BH (Group II) (mean 6.93 ± 2.83 pg/ml versus 1.41 ± 0.88 pg/ml, p < 0.001). Moreover, patients with HT who were infected with BH (Group II) showed a significant higher level of serum IL-17 compared with those with HT without BH infection (Group I; mean 6.93 ± 2.83 pg/ml versus 3.25 ± 1.55 pg/ml, p = 0.003).

After treatment of Blastocystis hominis infection:

After treatment of the BH infection, 10 patients in group II reported an improvement in fatigue, while constipation has improved in five patients only, and diarrhea disappeared in all six patients.

In group II, both systolic and diastolic blood pressures remain significantly higher than in the control group. There was no significant difference in both systolic and diastolic blood pressures in group II before and after treatment of BH infection.

TSH was significantly decreased after treatment of the BH infection.

In group II, anti-TPO was decreased significantly after treatment of the BH infection.

Also in group II after treatment of the BH infection in patients with HT, serum IL-17 was significantly decreased in comparison with its level before treating the BH infection.

Thus, it was shown in group II that treatment of a BH infection in patients with HT has resulted in a significant reduction in serum TSH, anti-TPO, and IL-17.

In 2015, for the first time in the literature a case report was published showing that treatment of BH infection can prevent the development and further stop progression of HT.

Conclusion

High serum IL-17 level in HT patients infected with BH supports the potential role of BH in the development of HT. Furthermore, BH eradication in patients with HT resulted in a reduction of serum IL-17 and improved thyroid parameters. Hence, treating BH infection can ameliorate HT and even stop its progression. Yet, such a relation is not definitively proven, and our findings can provide the basis for further multifaceted prospective studies with larger sample sizes.

This might be something.

[park_bear]

Fascinating.

[Bolt_Upright]

Clinical efficacy of Saccharomyces boulardii or metronidazole in symptomatic children with Blastocystis hominis infection pubmed.ncbi.nlm.nih.gov/209...

A, S. boulardii (250 mg twice a day, Reflor® (from what I can tell, 250 mg = 5 billion CFUs)

At the end of the first month after inclusion, clinical cure rate was 94.4%

rxlist.com/saccharomyces_bo...

"Saccharomyces boulardii is LIKELY SAFE for most adults when taken by mouth for up to 15 months. It can cause gas in some people. Rarely, it might cause fungal infections that can spread through the bloodstream to the entire body (fungemia)."

For treatment of infections due to the ulcer-causing Helicobacter pylori bacterium: a dose of 5 billion colony-forming units (CFUs) of Saccharomyces boulardii daily in addition to usual treatment.

[Bolt_Upright in reply to Bolt_Upright]

The mallotus oppositifolius plant works also, but good luck finding one.

[Bolt_Upright in reply to Bolt_Upright]

Swanson Probiotics- Saccharomyces Boulardii with Prebiotic MOS swansonvitamins.com/swanson...

[LAJ12345 in reply to Bolt_Upright]

Yay, have some of that in my fridge 🤣

[Bolt_Upright in reply to LAJ12345]

This does not surprise me one bit. Good job you!

"Saccharomyces boulardii is LIKELY SAFE for most adults when taken by mouth for up to 15 months. It can cause gas in some people. Rarely, it might cause fungal infections that can spread through the bloodstream to the entire body (fungemia)."

[LAJ12345 in reply to Bolt_Upright]

I think if you have compromised immune system it might not be a good idea then

[Bolt_Upright]

Blastocystis: how do specific diets and human gut microbiota affect its development and pathogenicity? 2017 ncbi.nlm.nih.gov/labs/pmc/a...

[Bolt_Upright]

Blastocystis: a parasitic enigma fxmedicine.com.au/blog-post...

[MarionP]

Very interesting. I think you've earned your pay for the week.

[jeffmayer]

I must be dense can somebody translate to English please

[Bolt_Upright in reply to jeffmayer]

You are not dense. I usually start posting before I have made sense of everything. Here is the short and dirty:

Elevated IL-17 is related to PD. Well IL-17 is also related to Hashimoto's. And Hashimoto's is also related to PD. And frozen shoulder is related to PD and Hashimoto's. And... IL-17 can be caused by a parasite called Blastocystis hominis. And... If you have HT AND this parasite and kill the parasite, the HT stops progressing. So if the HT and PD were caused by the same thing... would the PD stop progressing too?

Blastocystis hominis is the most common intestinal parasite in the world. 15% of people in first world countries have it. There is much debate as to where it is benign or not. Blastocystis hominis is hard to test for, but it turns out it is easy to treat. Saccharomyces boulardii seems to work as well as the drugs, pubmed.ncbi.nlm.nih.gov/209... , and Saccharomyces boulardii is really cheap. About $5 for a month's supply.

There is a risk to taking Saccharomyces boulardii. You could get a systemic fungal infection. I have ordered some, but not 100% sure I will be taking it.

[jeffmayer in reply to Bolt_Upright]

Thanks now it makes sense

[Fumaniron]

Fascinating. You’ve definitely contributed a lot recently! Thank you!

[akgirlsrock]

Nice info, are you taking the Boulardii? Fungal infection in the blood, sounds scary. I'm going to read more. Diatomaceous earth food grade for killing parasites, I wonder if that would work. Thank you, Maria

[Bolt_Upright in reply to akgirlsrock]

I have ordered my Saccharomyces boulardii . Not 100% sure I will take it, but I will do something. Reading more is a good idea.

[Bolt_Upright in reply to akgirlsrock]

Diatomaceous earth. That's a new one for me. Looks like it could be part of the solution: naturimedica.com/parasite-t...

Garlic is supposed to be good for BH. I have added 2 huge tablespoons of minced garlic to my diet every day.

[Bolt_Upright in reply to Bolt_Upright]

I'm working Zeolite back into my protocol too. Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions mdpi.com/2076-2607/6/2/35/htm

[LAJ12345 in reply to Bolt_Upright]

Yes, I think it worth doing a course of it. But not be on it permanently. What brand are you using? We used Toxaprevent. What other brands are there?

Also have you heard of mimosa pudica from Microbe formulas?

This is a plain English article on parasites. It mentions “blasto”. One remedy is m.pudica. I have used it for urinary tract infection along with there herbal formula 1 “parasite killer” and it worked!

nourishingtherapies.com.au/...

“Mimosa Pudica is still fairly new when it comes to parasites and definitely not as well known as other herbs like wormwood, black walnut, cloves, etc.

I first heard about it in the Parasite Summit last year, everybody seemed so excited by it, and for good reasons it turns out… it’s an absolute game-changer when it comes to gut health, and ridding yourself of parasites. It works in a totally different way to other anti-parasitic herbs. It actually forms a jelly-like substance in the GI tract which is very sticky and act a bit like a scrubber in your gut. This cleaning action can have a dramatic impact on the good functioning of your small and large intestine.

But what’s even better is that it seems to suffocate or ‘envelop’ the parasites and help to get them out of the body. There are many people who report stories of long worms coming out of their gut after using Mimosa Pudica…

I have to admit, I wasn’t so convinced at first, until I saw some weird stuff coming out of my own bowel after a week of using it! I didn’t dare to take a closer look, but it was stringy and gross…. I had to pull it out by hand, in a public toilet!!! But better out than in, right? And then more came out in a colonic I had recently… the woman giving the colonic couldn’t believe what she was seeing and kept taking photos… we all get excited by something I suppose 😉

So, to make a long story short, I highly recommend trying Mimosa Pudica.”

[Bolt_Upright in reply to LAJ12345]

I am using Zeolite Pure right now. I will eventually switch to Panaceo Zeolite. Panaceo is what they use in all the studies. I can order it from Germany through either German Amazon or directly from Panaceo.

I found this interesting page while looking for Toxaprevent: mthfrsupport.com.au/2021/02...

Interesting. Only $20 for 3 month supply.

mimosa pudica

doublewoodsupplements.com/p...

[LAJ12345 in reply to Bolt_Upright]

Interesting. It seems to conclude it is safe in the end.

I hadn’t seen that other brand of m.pudica , thanks.

[LAJ12345]

ncbi.nlm.nih.gov/pmc/articl...

Can it actually be a positive thing in the gut? Like some bacteria are?

“As mentioned above, there can be several explanations for Blastocystis pathogenicity. It may depend on the Blastocystis subtype: different subtypes can excrete protease enzymes which are able to take part in the induction of virulence [49, 99, 100]. Most Blastocystis isolates found in stool samples are in cyst or vacuolar forms. The amoeboid form is rarely seen, but is mostly associated with symptoms [3]. Therefore, amoeboid forms of Blastocystis are probably pathogenic. A large number of the parasites in the intestine (>5 parasites per high-power field) are also connected with gastrointestinal symptoms [1]. Human gut microbiota composition and the immune system are also deciding agents in the pathogenicity and occurrence of the parasite. In immunocompromised individuals, such as those with HIV infection, the prevalence reaches 38% in developed countries [28], and an association with diarrhea is suggested. The nutritional status of an individual may be one of the most important risk factors for co-infection [3]. Children and the elderly are highly susceptible to Blastocystis infection [20, 31], whereas research interestingly showed that people aged 30–50 years old are mostly infected [33]. Blastocystis can also have beneficial effects stemming from its ability to modulate the host immune system. One mechanism of action is the stimulation of mucus production, via the cytokine IL-22, which alleviates symptoms of colitis, improving gut health [101]. Perhaps Blastocystis is more common in healthy people because it helps maintain a healthy mucus layer in the intestine, either directly or through interactions with beneficial bacteria or the immune system [5]. Blastocystis have been shown to be more prevalent in patients suffering from IBS [18, 102–106]. A 2014 study by Nourrisson et al. [107] suggests that Blastocystis may be used as an indicator of microbiota changes; a lower abundance of Bifidobacterium spp. and Faecalibacterium prausnitzii were reported to have protective and anti-inflammatory effects, which could lead to intestinal dysbiosis and IBS. Nagel et al. [108] confirmed these results in 2016. On the other hand, in 2016, Audebert et al. [109] suggested that colonization by Blastocystis could be associated with a healthy gut microbiota. Their study showed a higher bacterial diversity in Blastocystis-colonized patients compared to that identified in Blastocystis-free individuals. In Blastocystis-colonized patients, there was a higher abundance of the Clostridia class and Ruminococcaceae and Prevotellaceae families, while Enterobacteriaceae were enriched in Blastocystis-free patients. The most recent results of the latest studies leave the pathogenicity of Blastocystis still unclear and this is similar to the chicken and egg question: which came first? It is still a mystery. Is Blastocystis an agent of the gut dysbiosis and changing the microbiotic diversity, or are the metabolic dysfunctions and changes in the content of microbiota the reason for the higher colonization by Blastocystis? There is a possibility that some species of bacteria are triggering the protease activity of Blastocystis, which causes the gastrointestinal symptoms. It may also depend on parasitic subtype. To address this, further studies in humans are required [109].

[chartist]

Fighters of Blastocystis hominis are potent multi probiotics including SB, fiber, oil of oregano, colloidal silver, Grapefruit Seed Extract, Wormwood and Artemisinin among others such as Ivermectin. It always seems to come back to gut dysbiosis as the bottom line. An imbalance between the pathogenic organisms and the health promoting organisms of the gut. Rebalancing the gut microbiome toward increased health promoting organisms and away from pathogenic organisms generally gives significantly improved health. Overgrowth of pathogenic parasites, bacteria, fungus and viral entities always promote bad health. PD is not an exception to the rule.

Art

[Bolt_Upright in reply to chartist]

Thanks Art! Being a Trump supporter, I was pleased to see that I could go to the feed store and get myself some Ivermectin. I just hope and pray that fixing the gut stops progression.

[chartist in reply to Bolt_Upright]

Bolt,

What does one have to do with the other?

Art

[Bolt_Upright in reply to chartist]

I should not have mentioned it. It's the whole Covid thing. They say the Trump supporters try to cure Covid with horse de-wormer (and I would hit the feed store before trying to convince my doctor to prescribe Ivermectin).

[chartist in reply to Bolt_Upright]

Yeah, I don't get it, Trump didn't even use Ivermectin or promote it.

My sister asked her doctor to prescribe Ivermectin and she got the script and picked it up at her local pharmacy.

Art

[Gibberesh in reply to chartist]

Ivermectin for covid was discovered after Hydroxychloroquine, which was promoted by T (no politics... bummer.)

[Hidden in reply to Bolt_Upright]

Bolt, think of skin biome and oral biome too. I just posted about the fungus that causes are skin issues crossed the BBB.

[LAJ12345]

byronherbalist.com.au/paras...

Berberine and garlic get a mention here too

[Bolt_Upright in reply to LAJ12345]

Thanks! SB, Berberine, Garlic, mimosa pudica, I need to work out a rotation.

[Hidden in reply to Bolt_Upright]

I was using a lot of garlic for this purpose too but it increases iron absorption so now I’m not so sure

[Bolt_Upright in reply to Hidden]

Yikes! Here is a related article: Quercetin Inhibits Intestinal Iron Absorption and Ferroportin Transporter Expression In Vivo and In Vitro 2014 ncbi.nlm.nih.gov/labs/pmc/a...

[Hidden in reply to Bolt_Upright]

Yep! I’ve reduced garlic and onions too and added Quercitin. Parmesan contains glutamate Btw

I wanted to cry when I read that

[Bolt_Upright in reply to Hidden]

Thanks! healthunlocked.com/cure-par...

[gomelgo]

Oh boy, I'm getting an eyeful and brainfull too. So I came looking for frozen shoulder help. And I see (a few years later) that this is likely yet another gut related issue!!! I wonder if instead of taking more pills, I should just go get myself my first ever colonic.