Hi
Kindly respond to this post if you use sinemet tablet as a bridge to make the Rytary work. If you do this, how much sinemet do you use? Will this method disrupt the functioning of Rytary as a slow release medication designed to work up to 3hours or more, on the long run leading to motor fluctuations (wearing off)? Do you feel severe fatigue as the day goes by , when you do this? I currently use Inbrija as a bridge, but I was told by my MDS that I cannot use Inbrija more than 5 times.
The only difference between inbrija And c/l, is the limit of 5.
Use half tablet as kick starter. It’s ok
Are you by any chance taking a multivitamin or B complex vitamin in the mornings?
Hi park-bearI take my multivite at bedtime. I guess it would be better in the mornings.
Oreolu... I don't know when you were diagnosed, but it might take you less than Roy's 1 hour for the IR to take effect. It used to take me 20 minutes but now it's 45 minutes for me.This has been suggested before, people on this great forum should add when they were diagnosed to their profile so responding to their question is just a click on their profile picture for more accurate info/answers.
I always ate some crackers to get it to kick in
I wish I could help more. I use Rytary. And I have inbrijia for in between times. It does seem like it would be easier to just take a pill than juggle an inhaler. Lately it doesn’t feel like it’s working either. So you’re like me it’s only five times per day. And I think we have to stick to the dosage each time. I am OK in the morning but in the afternoon Rytary doesn’t seem to work. And if I use the peace pipe so to speak, that doesn’t seem to help much anymore either. I hope you get a resolution. I’m trying nourianz which is supposed to kind of extend the rytary. But I haven’t taken it long enough to have an affect.
I've taken Rytary for over 5 years. I was diagnosed 12 years ago. What you are describing is probably an undermedicated situation. I understand your desire to not increase your meds, but there comes a time when you have to. Right now I take Rytary six times a day every 4 hours. I've recently had to have it increased and now my dose is one 245 mg plus a 95 mg capsule. I wish I'd done it sooner.
I've tried taking other types of c/l to bridge the gaps, but nothing really worked very well. Finally decided that just taking more Rytary was best. Good luck and let us all know if you find something that works better.
Hi JAS9
Do you have dyskinesia? I assume you wanted to write that you take 6 Rytary capsules every 4hours. If this is true, then you are taking more pills than me.
I occasionally have mild dyskinesia. As they say, everyone's different, so comparing our symptoms might not be useful. No, I don't "take 6 Rytary capsules every 4hours". I will re-word my dosing explanation so that it will hopefully make more sense to you.
Every 4 hours (both day and night) I take one Rytary capsule, which has 245 mg of Levodopa in it, and I also take one smaller Rytary capsule which contains 95 mg of Levodopa. So, every 4 hours, I take 2 capsules but they have 2 different amounts of Levodopa and they add up to 340 mg of Levodopa.
To compare how much we each take, it might be easiest to add up all of the mg of Levodopa we each take in 24 hours. For example, I take 2040 mg of Levodopa in 24 hours (340 x 6). Of course all of this Levodopa is in Rytary. You can't compare that with other forms.
If I took 6 Rytary every 4 hours, as you suggested, and if each pill had 245 mg, that would be 1470 x 6 = 8820 mg of Levodopa per day. Much more than the 2040 mg I actually take.
PS, in case you don't know, the amount of Levodopa in your capsules is the second number in its description. The first number is how much carbidopa is in each capsule.
I take Rytary in the morning and add 1.5 carbo/levo. I understand the Rytary has beads in it. They take awhile to dissolve. This is suppose to give us a smoother transition instead of a rollercoaster effect.
I had stuttering, fast speech, and was impossible for people to understand. The doctor figured out that it was too much Rytary and we brought down the dosage significantly. Now, I am almost back to normal. Something I was unprepared for.
RKM
i believe due to research that you should never take sinemet and rytary. see my rytary warning posted on hu today. check the below link for more info.
DYSKINESIA! DO YOU HAVE IT? IF SO, WHEN DO YOU GET IT AND HOW LONG DOES IT LAST? HOW DO YOU TREAT OR PREVENT IT? PLEASE HELP. 
Seeking a 2nd opinion Movement Disorder
Looking for people who have phased out Carbidopa/Levodopa in favor of an all-mucuna program
Slow release cardopa/levodopa 
Need your help on this one. Please provide your input.
