Taiwan reveals new findings to treat Parkinson's disease

[Farooqji]

In this pioneer study, PS128 was used as adjunct treatment for a group of twenty-five PD patients for three months. Participants continued to take their own prescribed anti-Parkinsonian medications throughout the study. Significant improvements were shown in motor symptoms and in subjective reported quality of life.

biospectrumasia.com/news/98...

[Farooqji]

Lactobacillus plantarum PS128 is a specific strain of Lactobacillus plantarum, a bacterium of the genus Lactobacillus. It won "Probiotic Product of the Year" at the 2018 NutraingredientsAsia Awardsen.wikipedia.org/wiki/Lacto...

its readily available and can be started taking right away

amazon.fr/Synergia-PS128-Ne...

medicine photo

[parkylot in reply to Farooqji]

Thank you for this. Although my search for this PS128 strain on US Amazon failed to bring up the same product. I would imagine the probiotic should specify PS128. Not all probiotics are the same ?

[park_bear in reply to parkylot]

Lots of products with Lactobacillus plantarum on Amazon US but none are PS128. Presumably PS128 needed.

[laglag in reply to park_bear]

I found this on Amazon & ordered 60 days worth. I hope it's the same thing.solaceprobiotic.com/product...

[park_bear in reply to laglag]

Good find. As far as I can tell you have to order direct from the vendor rather than from Amazon.

[simonasays in reply to laglag]

wondering if you have anything to report on Solace? My father is considering trying it...

[laglag in reply to simonasays]

No I haven't tried it yet. I keep thinking about it, but it kind of scares me. I want to talk to my neurologist first. Something made me buy it. It's not going to help me sitting in the refrigerator! I'll let you know when I start it.

[Hidden in reply to laglag]

I have ordered it too. It’s in my fridge waiting for me also!

[simonasays in reply to Hidden]

well, my dad purchased it without talking to me and in his usual impulsive fashion is giving it a go. So I will be sure to report it once he has anything to report.

[AmyLindy in reply to simonasays]

Sounds familiar

[Farooqji in reply to simonasays]

He is using his impulsive behaviour in a good way

[Sapeye2020 in reply to laglag]

here is some details about the owner and their research.

oryxbiomed.com/

[Nanismami in reply to Farooqji]

I have been taking ps128. Product can be purchased at solace.comIt comes from Taiwanese fermented mustard greens

[Farooqji in reply to Nanismami]

Have you felt any improvement so far

[Parkinsonjisung]

Bit more detail here:prnewswire.com/news-release...

Its basically an ad for the company. 3 month trial without placebo essentially proves nothing. No harm trying it though.

[Farooqji in reply to Parkinsonjisung]

The company seems genuine as they have straight away refused to sell it to me due to the reason for not being able to send it under controlled temperature to my country

[Parkinsonjisung in reply to Farooqji]

Ya, I'm not saying it's a scam. Was just saying tye trial design makes it pointless

[John_morris71]

Please see link

solaceprobiotic.com/pages/w...

solaceprobiotic.com/pages/b...

solaceprobiotic.com/product...

[laglag in reply to John_morris71]

Do you know if anyone has tried this or if anyone knows much about it? It sounds promising??

[John_morris71 in reply to laglag]

No, I have not yet tried it for my mother. I just found it. Will try in another month or two. I would want to try it for at least 4-6 months at a stretch before deciding.

[Farooqji in reply to John_morris71]

Please let us know about the results after use for some time. Unfortunately none of the supplier provide shipping to my country

[laglag in reply to Farooqji]

I appreciate you sending this information. I'm going to ask my neurologist and internist to see if they know anything about it.

[simonasays in reply to John_morris71]

Hi There,

Wondering if you began Solace for your mother?

[John_morris71 in reply to simonasays]

Yes, I have started Solace and it has been a couple of weeks. Giving her 1-0-1 for now. Plan on giving her this dose for another 6 months. I may make it 1-1-1 the max dose as suggested in the box ( after a couple of months). Will provide an update by end of June/early July.

[Despe in reply to John_morris71]

Hi John and everyone on Bio-Kult,

Will you stop Bio-Kult and start Solace? Solace sounds very promising but so did Bio-Kult.

[AnArtist]

Has anyone come across this?

[Farooqji]

I had contacted the main Taiwanese manufacturer about their sub-suppliers. Their reply was as under:"I’m glad to receive your email. Currently, we do not have a distributor that covers your country. PS128 is a delicate probiotic that is best kept refrigerated and shipped via cold chain, and logistically, that is quite difficult in your country. Our Singapore distributor, Multibiotics | Activhealth | Healthy Mind, Healthy Body, may be an option. Please contact them directly and see.

If there is anything else I can help with, please let me know.

Only the best,

Sam Noble

Int'l Dept. Product Manager, Bened Biomedical

mob: [phone] | tel: [phone]

benedbiomed.com"

[Leslim in reply to Farooqji]

Singapore activhealth.com.sg/

[jaberalhddad]

Thank you Farooqji for this post .

[Sapeye2020 in reply to jaberalhddad]

here is a report on LB PS 128 by Science Direct

published Nov. 2020

sciencedirect.com/science/a...

Abstract

Evidence suggests that the Parkinson’s disease (PD) pathogenesis is strongly associated with bidirectional pathways in the microbiota-gut-brain axis (MGBA), and psychobiotics may inhibit PD progression. We previously reported that the novel psychobiotic strain, Lactobacillus plantarum PS128 (PS128), ameliorated abnormal behaviors and modulated neurotransmissions in dopaminergic pathways in rodent models. Here, we report that orally administering PS128 for 4 weeks significantly alleviated the motor deficits, elevation in corticosterone, nigrostriatal dopaminergic neuronal death, and striatal dopamine reduction in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (MPTP)-induced PD mouse models. PS128 ingestion suppressed glial cell hyperactivation and increased norepinephrine and neurotrophic factors in the striatum of the PD-model mice. PS128 administration also attenuated MPTP-induced oxidative stress and neuroinflammation in the nigrostriatal pathway. Fecal analysis showed that PS128 modulated the gut microbiota. L. plantarum abundance was significantly increased along with methionine biosynthesis-related microbial modules. PS128 also suppressed the increased family Enterobacteriaceae and lipopolysaccharide and peptidoglycan biosynthesis-related microbial modules caused by MPTP. In conclude, PS128 ingestion alleviated MPTP-induced motor deficits and neurotoxicity. PS128 supplementation inhibited neurodegenerative processes in PD-model mice and may help prevent PD.

Enjoy!

[Millbrook in reply to jaberalhddad]

Hi Jaberal. Welcome back

[jaberalhddad in reply to Millbrook]

Thanks

[mauigirl18]

I have received mine today from Solace and will start with one per day and gradually up to 3 per day.

[laglag in reply to mauigirl18]

Keep us updated please. I have some in my fridge but haven't tried them yet. Good luck!

[mauigirl18 in reply to laglag]

I will! Thank you!

[laglag in reply to mauigirl18]

I started using cinnamon a few weeks ago. I'll let you know how that works.

[mauigirl18 in reply to laglag]

Great! I used it briefly and then stopped. Curious to know how you do with it.

[laglag in reply to mauigirl18]

Did it help you even a little bit?

[mauigirl18 in reply to laglag]

It may have. I wasn't sure. I started other things at the same time and am trying to isolate to see what really works.

[mauigirl18 in reply to mauigirl18]

B1 seems to really help. I'm not on any meds yet. Trying supplements etc first.

[Farooqji in reply to laglag]

Why are you hesitating to use it? If it doesn't benefit you, It will not harm you either

[laglag in reply to Farooqji]

The description includes the word "psychobiotic" . That kind of scares me.

[Farooqji in reply to laglag]

By definition Psychobiotics is a term used in preliminary research to refer to live bacteria that, when ingested in appropriate amounts, might confer a mental health benefit by affecting microbiota of the host organism.[1] Whether bacteria might play a role in the gut-brain axis is under research.en.m.wikipedia.org/wiki/Psy....

[laglag in reply to Farooqji]

Thanks for your help, knowledge, encouragement.About a week ago I started taking Protandim, again, (I took it a few yrs ago, but I took 1/day & now I've been taking 2/day (1 morning and 1 night). Taking 1 helped give me an overall feeling of well-being. Recently a friend talked to a lady from India in the drugstore and she was buying 1,000 mg of Ashwagandha. My friend was looking for something to help with stress so she asked the lady if it worked. The lady said yes & it also is really good for PD. My friend, which happens to be my boxing coach, was shocked because she had nothing on that would show that she was involved with any thing about PD. The lady said in India they use it a lot for PD. My coach thinks it was a "sign" for her to be there at that particular place and time. So I started taking 2 Protandim a day and I've been feeling remarkably good. I'm going to keep taking the Protandim for another week and see how I feel and at that time I will try the PS128 and I'll let you know how that goes.

BTW.... In 1 Protandim there is:

Milk thistle 225 mg

Bacopa 150 mg

Ashwagandha. 150 mg

Green tea. 75mg

Turmeric. 75 mg

Keep fighting!🥊

[Hidden in reply to laglag]

Hi DebbieAre you still taking this? I use powder forms of these same supplements but I wonder if pills would be better at making it past my stomach acid.

[laglag in reply to Hidden]

Yes, but not every day.

[Farooqji in reply to mauigirl18]

Thanks for sharing. Anxious to know the results. Please keep us updated. I can't purchase it due to the reason mentioned above

[enjoy2013]

Hello are all,Any update you care to share?

Protansim? Solace? PS128?

[Leslim in reply to enjoy2013]

activhealth.com.sg/ Singapore

[Millbrook in reply to Leslim]

Please share your results on PS 128

[Leslim in reply to Millbrook]

Hi Millbrook, I just started on the following multibiotics today.. Will keep u all posted

Multibiotics from Activ Health

[Millbrook in reply to Leslim]

How is it going Les? My husband is still on it. Can’t do without and he is as well as can be. Praise God!

[TL500 in reply to Millbrook]

Hi Millbrook, how long apart from food or meds or supplements before your husband takes PS128 at bedtime?And with how much water?

I have the Neuralli capsules form, 2 a day.

[Millbrook in reply to TL500]

Hi TL. He takes it about 2-3 hours after his dinner and only with a bit of water because he has nocturia- do not know it’s due to PD or enlarged prostate. Taking prostate supplements hv helped .

[TL500 in reply to Millbrook]

Thanks

[TL500 in reply to Millbrook]

Does he take it near any supplement, eg. magnesium?I usually take PS128 in the morning and magnesium both morning and night.

Now having read the study it said participants were given ps128 at bedtime, and your husband takes it at bedtime, both with good results, I want to try take it at bedtime now. Do you think it's ok to take it near or with magnesium at bedtime? Thanks

[Millbrook in reply to TL500]

He takes his magnesium at night before bedtime also. It seems to be alright

[TL500 in reply to Millbrook]

Thanks

[TL500 in reply to Millbrook]

From your list it looks like your husband takes only 200mg B1 per day?Did he have to trial and eventually came to right dose of 200mg?

[Millbrook in reply to TL500]

We started in feb 2019 on 500 mg then after 2 weeks 750 mg then 1000 mg. At 1000 mg symptoms worsened so stopped for 3 days then cut to 500 g. His active dreams seemed to be worse when he had too much. At one point was only talking 100 mg then read a report that Art posted that said there was benefit in taking 200 mg. I then increased to 200 mg and seems to be alright there. He takes 200 mg B1 and a basic B complex which has another 100 mg B1 in it.

[TL500 in reply to Millbrook]

Good for him. I still don't know if B1 can help me, I have been trying for at least a couple of years and still can't tell whether to increase or decrease to suit or if it suits my body at all.

[laglag in reply to enjoy2013]

I bought PS128 from Solace a couple of months ago and have tried it 2 different times and after a couple of days it makes me start shaking. he shaking is more like being cold rather than a tremor. It happens about an hour before my meds are due and it lasts about 45 minutes after I take my meds. That's happened to me when I've tried other probiotics and I'm not sure why.

Protandim helps after I take it for about a week but doesn't seem to help more than 2 weeks, so I take it every once in awhile. The way it helps is it takes most of my symptoms away during my on periods and my off times are shorter and not as bad.

I know this sounds confusing but it's confusing to me also.

Unless it's some type of "placebo effect"?

[TL500 in reply to laglag]

So taking Protandim once in a while helps you?What is it supposed to do? Thanks

[laglag in reply to TL500]

It's supposed to reduce oxidative stress andThere are 2 kinds. One is NfR2 which is what I'm taking. The ingredients are:

Turmeric Extract (Rhizome) Turmeric comes from the rhizome of a herbaceous perennial plant of the ginger family, Zingiberaceae. ...

Bacopa Extract (Aerial Part) ...

Ashwagandha (Herb) ...

Green Tea Extract (Leaf) ...

Milk Thistle Extract (Seed)

The other one, NfR1 which I'm thinking of trying and it has:

Acetyl L-Carnitine. An amino acid (a building block for proteins) that is naturally produced in the body. ...

Quercetin. Quercetin is a naturally occurring antioxidant, a flavonoid that is abundant in various fruits and vegetables; it is a NRF1 activator. ...

Alpha-Lipoic Acid. ...

Grape Extract. ...

Coenzyme Q10

They work together to reduce oxidative stress and reduce depression and anxiety. 🥊

[TL500 in reply to laglag]

Thanks laglag. I guess you know about Restore Gold? It has few of the ingredients you mentioned. I learnt about it from this forum.

[TL500 in reply to laglag]

It's From LAJ12345

[laglag in reply to TL500]

Yes I have. That's been on my mind. I assume you are taking it and you can see a difference? Do you have to take a lot of pills? Thanks!

[TL500 in reply to laglag]

I've just started. Don't know yet. According to instructions have to take 16 caps per day. I take 6, 6, 4 breakfast, lunch and dinner.

[enjoy2013]

I don't feel it looks like placebo effect.It sounds like you are maybe more responsive to dopamine so you have less "dopa-resistant symptoms" in on times and you are less deeply off in off times, it seems to be a change on the response amplitude rather than length (time). To make the difference with dopamine synthesis you could try increasing a bit your levodopa dose.

But my interpretation is very human-centric. Biology works in very mysterious and unpredictable ways. This is why, we don't always understand.

And the shaking, could it feel like chills?

[laglag in reply to enjoy2013]

They are similar to chills, but they aren't.