Phenylbutyrate for Alpha-synuclein Clearance from the Brain

[JayPwP]

michaeljfox.org/grant/pheny...

Objective/Rationale:

In our previous research, we have discovered that a drug called phenylbutyrate can turn on a protective gene in the brain and can prevent Parkinson’s disease (PD) in models that are genetically programmed to get the disease. The drug works by transferring abnormal proteins from brain cells into the bloodstream. We now want to see if the drug works in patients with Parkinson’s in the same way. If it does, the drug may be able to stop the progression of Parkinson’s disease.

[Hidden]

That was from 2013If anything positive came of it we would know by now

[JayPwP in reply to Hidden]

Or it was not patentable, and therefore not investable

😆😆

[Bolt_Upright]

What the heck? 8 years and not even a failed trial?

[Bolt_Upright]

It looks like they mixed it with something else and relabeled it AMX0035 but only seem to be testing it on ALS and ALZ:

ncbi.nlm.nih.gov/pmc/articl...

[Bolt_Upright]

Linh Nguyen wrote a thesis on this topic in 2017:

Stopping Parkinson’s disease with phenylbutyrate: The science, the history, and the miles left to FDA approval

epublications.regis.edu/cgi...

[Bolt_Upright]

This study is still going on. Pretty low key though. You can read about it in this college thesis: epublications.regis.edu/cgi...

The Study is NOT going on

I contacted Dr Freed who was running the study and the NIH refused to continue funding the study and it was stopped.

[Bolt_Upright in reply to Bolt_Upright]

The Study is NOT going on

I contacted Dr Freed who was running the study and the NIH refused to continue funding the study and it was stopped.

[JayPwP in reply to Bolt_Upright]

Thanks