Webinar: Inflammation in Parkinson's

[CPT_Helen]

Sign up for our next live webinar on Tuesday 3 March at 5pm (GMT) as the panel discuss the topic of inflammation in Parkinson's.

Sign up here: zoom.us/webinar/register/55...

[rriddle]

We've posted notes to this interesting webinar here:

parkinsonsblog.stanford.edu...

[Gioc in reply to rriddle]

Thank you riddle,

very current and interesting, finally something that " unsolidifies" the problem.

[AmyLindy in reply to rriddle]

Thank you!!!

[chartist in reply to rriddle]

rriddle,

I just got done watching the youtube video in the link you posted. I was disappointed after watching the one hour video as they didn't really address the issue of oxidative stress that is already known to cause much of the damage in PD and seems at least as important as inflammation in controlling the disease process.

As regards finding out if inflammation reduction can have any effect on PwP, melatonin in an RCT this year, at just 10 mg/night showed a reduction of TNF-alpha, IL-1b, NF Kappa b and IL-6 and the study clearly showed that melatonin had a positive impact in PWP after 12 weeks. Melatonin also significantly reduced oxidative stress and melatonin elevated gene expression of multiple components of the human antioxidant system, acted as a potent scavenger of multiple radicals that are known to be elevated in PD while also activating the Nrf2 / Keap1 pathway.

Melatonin at almost any dose up to 1,000 mg/day is likely to have a better safety profile than almost any drug which they might use for the purpose and has been used at 100 mg/day for 5 years with minimal side effects. A 100 mg/night study of melatonin might prove to offer even more benefit and given its proven safety profile at this dose, seems like a worthwhile option to consider. In ALS patients given 300 mg/day for up to 2 years, it reduced the redox system and inflammatory markers to healthy control levels. There is no established LD50 for melatonin in humans or animals.

Other studies have shown even more benefits.

Art

[Florida1994]

I would like to be added to the list. Thanks

[Florida1994 in reply to Florida1994]

I just read the post re melatonin. I don't know anything about it's use with other night meds like

[nldr18]

Hello Helen,

I just saw this posting and note that it was available on March 3. Is there a way to access it now? Thanks in advance for any assistance you can provide.

Natasha