If you have LLC and are taking Ibrutinib, is it advisable to inject the vaccine against Covid?, and wich one Pfizer, Moderna or J&J ?

[Geom2000]

I have been reading very interesting posts about CLL and the vaccine, but to this date I still do not know which is the best option since I read that one of the vaccines uses an attenuated virus, while others do not work like that, my question is also in the sense that having a problem with the immune system creates antibodies or not? Thanks for reading and any comments will be well received.

[cajunjeff]

My understanding is that as a general rule, even though those of us on ibrutinib are not likely to have a measurable antibody response to any covid vaccine, that we are still encouraged to take the first vaccine available to us. This includes Pfizer, Moderna and J&J vaccines. We are advised not to take any attenuated live vaccines that might be approved. They are not recommending we pause btk therapy (ibrutinib included) to get the vaccine.

Most sites I have seen encourage those of us with cll to discuss our vaccine options with our personal cll doctors as we are all very different and general rules might not apply to all of us.

Here is a discussion on the LLS site with vaccine info for us:

lls.org/covid-19-vaccines-faq

[AussieNeil Partner Founder Admin]

The only live/attenuated COVID-19 vaccine which has reached human clinical trials that I've been able to find is this one by Codagenix: clinicaltrials.gov/ct2/show...

Some vaccines use other viruses to deliver parts of the SARS-CoV-2 coronavirus into our body cells to initiate the development of immunity, but these vector viruses can't survive and replicate.

The best vaccine is the one that's easiest to get, given the even slight advantage of a partial immune response in reducing the severity of a COVID-19 infection. Trials are under way to determine how much protection we are likely to get and how to best measure that:

healthunlocked.com/cllsuppo...

Neil

[LeoPa]

Try to check previous posts, this was discussed here extensively I think the last few months

[lankisterguy Volunteer]

Please look for the box on this page labeled: Related Posts

*Vaccines - AstraZeneca, Moderna and Pfizer - Which one for CLL Patients. healthunlocked.com/cllsuppo....

*Fever After Second Covid-19 Vaccination with Moderna healthunlocked.com/cllsuppo...

*Pfizer vs. Johnson & Johnson COVID vaccines? healthunlocked.com/cllsuppo...

*The Moderna vaccine for COVID 19 healthunlocked.com/cllsuppo...

*Pfizer Vaccine/Ibrutinib healthunlocked.com/cllsuppo...

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And when you find a useful discussion, look for that same box on the new page, the contents will change to match the title of the posting.

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Len

[Geom2000 in reply to lankisterguy]

Thanks for the links , allready read the first one , but it doesnt clarify really wich one is the best, I will read the others . thanks again for your post

[cajunjeff in reply to Geom2000]

Which vaccine is best is an unknown. The efficacy rate does not even answer that question because the vaccines were tested among different populations at different times. A vaccine tested in rural Colorado early in the pandemic might have a better efficacy rate than a vaccine tested in NY at the epidemic peak, but that does not prove its better.

The current belief is all three of the vaccines available work very well in the general population and that we should take the first one available.

If you have options you can pick any of the three, but the one you thought was best might not end up being the best. and what's best for you might not be best for the next person.

[KatieBlue in reply to Geom2000]

It hasn’t yet been determined if one type vs another provides better results.

Neither uses an attenuated live virus. The J and J uses an adenovirus, while Moderna and Pfizer uses mRNA.

Much of the studies have been with the mRNA types as they had first EUA approval and people had access to them sooner. I’m hopeful studies are also being done on response to the J and J.

Stemming from concern about exposure risks when going for a vaccine, I opted for the J and J. Only had to venture out once.

About 2 weeks ago I happened to see a CBS Health Watch episode discussing concerns about a low or absent response to the vaccines in those taking immuno suppressive drugs, with a focus on transplant patients taking anti-rejection meds.

One of the transplant doctors talked about becoming concerned for his patients getting no or minimal protection from the vaccine. He also was concerned for himself because he is a heart transplant recipient.

After 2 rounds of an mRNA vaccine, he tested his antibodies and had none. Upon discussion and approval from his doctor, he then got the J and J vaccine. When he re-tested his antibodies they were “off the charts.”

Now this is purely anecdotal. And the episode made it clear this should not be done without a doctor ordering it. It raises many questions and more unknowns. We don’t know whether it was having two different types of vaccines that made a difference, if the J and J vaccine is more effective, if the mRNA took some time to kick in, if this was an anomaly in this individual, or even, at this point in time, whether “off the charts”antibodies equal a protective response. It is something that is being looked at, but it all takes time…

[lankisterguy Volunteer]

As cajunjeff says:" we are still encouraged to take the first vaccine available to us. This includes Pfizer, Moderna and J&J vaccines. "

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Len