This is an excerpt from a small study published last week by three CLL specialists including Dr. Mato:
Anti-SARS-CoV-2 S1/S2 antibodies were detected in 17/18 (94%) of never treated patients vs. 6/26 (23%) of treated patients. Additionally, 3/14 (21%) of those receiving BTK inhibitors, 2/14 (14%) of those who had received anti-CD20 mAb within 12 months, and 0/7 (0%) of those receiving venetoclax with anti-CD20 mAb within 12 months tested positive for anti-SARS-CoV-2 S1/S2 antibodies.
and here is the article link:
nature.com/articles/s41375-...
Not sure as a CLL treatment naive over 71, I would make the grade? But, I can wait and take as much care as I can to remain Covid 19 naive.
The authors did not take the time to differentiate >70 vs <70 in treatment naive — or other populations. Frankly, this article doesn’t really say much at all — especially given a small sample size.
I am 68 and W&W (treatment naive), but this tells me nothing about my chances. The difference between 68 and 71 is minimal. The average CLL diagnosis is at age 71. Also, authors are using yet another analyzer for COVID antibodies .....
More important than a specific age is probably how long you have had CLL and what your ALC is. The longer you have had CLL the less good B cells you will have left that can produce antibodies. I would guess that any untreated CLLer who can produce close to normal IGG levels without the help of IVIG, could produce Covid antibodies
john
Not sure I feel confident with the information in the excerpt being habit-changing for me, but I appreciate your sharing it. Thank you.
It’s official Study shows T cells are activated against Covid after vaccination 
Imbruvca and covid vaccines
mid-year covid vaccine
