Paraimmunoblasts?

[Phs2385]

Hi all,

The doctor told me my father has paraimmunoblastic cells which make the cancer even more aggressive. Does anyone have experience with this; do any studies show a drug that can kill these cells?

Thank you so much.

[lankisterguy Volunteer]

Hi Phs2385,

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You may know that CLL is considered a rare disease, and B-PLL is a really rare vaiant or cousin to that. Your question on paraimmunoblastic cells had me Googling and finding few mentions of that in the last 20 years. So I don't expect you will get many helpful responses.

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Most of our CLL treatments (except some Chemo) don't kill cells directly, but alter the behavior of our Immune systems or the cell signalling to make the cancer cells stop hiding in the nodes or stop living too long. You may need a CLL expert that understands the genetic signatures and protein signaling of those paraimmunoblastic cells to say if the modern targeted therapies will also affect them. If the paraimmunoblastic cells grow very quickly (like DLBCL cells or ALL cells) then a Chemo regimen might be suggested to kill the cells directly,

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Len