Polyps and CLL

[DanaNicholson]

Is there any connection between CLL and polyps? Does anyone know? Apparently I have a polyp in the gastro intestinal lining and I wondered if CLL lends itself to polyps forming.

[lankisterguy Volunteer]

Hi DanaNicholson,

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First, I suggest you edit your original post on this page to "lock" it (restrict it to only our community members, so Google searches will not display the question or our answers).

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Use the "More v" next to the blue boxes, and choose "edit" then change the answer to the question at the bottom " Who can see my post?

Anyone to Only community members

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Next I will postulate that CLL shows up in many unexpected places, and when they do, it causes different issues for each of us.

When I was first diagnosed, I had a CT scan and colonoscopy - due to low iron - checking for bleeding.

Both showed a thicker than normal lining in my colon. A biopsy noted the abnormally high number of CLL cells in the lining. But I had no polyps.

After my first treatment, the thick lining has never re- occurred.

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But I have also had skin issues, and biopsies also turned up way too many CLL cells and T cells in a specific layer of my skin. No one can explain why, but they are there.

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Many CLL patients have auto immune problems (arthritis, exaggerated bug bites, Hashimoto's, Ryauds), see the full list:

webmd.com/a-to-z-guides/aut...

Can anyone prove that CLL caused their autoimmune disease?

No,

but we have them far more often than people without CLL.

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So, to answer your question- I suspect that there is no proven link between CLL and colon polyps, but since the colon is the largest organ in our immune system and CLL is essentially cancer of the immune system- I will bet that someday a link will be found.

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Len

[LovecuresCLL]

No NOT directly.

I think there is only an association if you have malignant cells with changes in expression of tumor suppressor gene p53. I imagine.

In colon carcinoma, p53 is decreased and K-ras is increased. Polyps are the precursors to colon adenocarcinoma.

There is p53 protein expression in B-CLL. is a marker of disease progression and poor prognosis. Is your CLL expressing p53?

Polyps are a low grade dysplasia of the colon epithelial cells.

Leukemia is a malignancy of lymphocytes.

P53 controls division and cell death is found in many cancers so that’s is an association. But not a close one at all.

Cancer in all different in every organ of the body is a hugely complicated phenomenon.

That’s like saying are dogs related to cats. Or cats related to a saber toothed tigers. Yeh they are all mammals. But are lizards related to monkeys? We all crawled out of the sea from some single celled organism.