Fish test for 13q

[Nour80Leen2011]

Is it better to have the result of Fish test for 13q to be deleted or not deleted ? Thank you

[AussieNeil Administrator]

Surprisingly, it's the loss of this chromosome arm (13q del) that provides the most favourable outcome with CLL: cll-nhl.com/2012/07/13q-wha...

[Jonquiljo in reply to AussieNeil]

This has always been confusing to me. How much (just relatiely) does a 13q deletion matter? I have tried to read up on this and it bring all sorts of other things into the picture such as IgVh mutatioal status and which class of heavy chain your malignant b-cell clone contains.

Anything that sorts all this info out? Or am I just missing something basic? Thanks.

[AussieNeil Administrator in reply to Jonquiljo]

I can recommend Jeff Sharman's blog articles. Easy to read, yet he goes into considerable technical depth: healthunlocked.com/search/s...

[Jonquiljo in reply to AussieNeil]

Thanks

[Wroxham]

CLL Research News Blog. Scientific information. How many 13q deleted cells there are, may be important in disease progression.

AussieNeil

Hi Neil

I found this from searching for information. There is also a reply from Chris Cllcanada about 13q. It showed that 13q can in some instances be aggressive if unmutated!!.

I was wondering if you or Chris could repost for me .

I have limited use of phone only, having just moved and cannot find the reply.

Hope you are well

Sue

[Big_Dee in reply to Wroxham]

I am 13q deleted and un-mutated. I went from normal to 110 WBC and 68 ALC in 10 months, so my CLL is very aggressive.

[Wroxham in reply to Big_Dee]

Hopefully bigD we'll get a reply this evening. All our time clocks are different.

Best wishes

Sue

Ps I too am unmutated and 13q. Currently on my 4th treatment in 4 years.

[Big_Dee in reply to Wroxham]

Second post

[Big_Dee in reply to Big_Dee]

Sorry testing posting