Ibrutinb or Idelalisib not working? Patients swapping had mostly favourable outcomes according to a study of 178 CLL patients.

[AussieNeil]

From Medical News today:

"Chronic lymphocytic leukemia (CLL) patients who stopped taking the kinase inhibitors (KIs), ibrutinib or idelalisib, had mostly favorable outcomes when they switched to the alternate therapy, according to a large multi-center study, conducted in part at the Perelman School of Medicine at the University of Pennsylvania.

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Patients who discontinued ibrutinib or idelalisib and went on to be treated with the other kinase inhibitor had durable responses, the researchers report. The objective response rate was 50 percent and median progression free survival was 11.9 months. Responses were most durable for patients who discontinued ibrutinib or idelalisib because they experienced side effects that made it difficult for them to continue taking the drug." (My emphasis)

medicalnewstoday.com/releas...

Neil

Photo: Bee approaching a naked lady/Easter lily bloom.

[MartyR]

Neil,

Interesting article about patients discontinuing ibrutinib or idelalisib and went on to be treated with the other kinase inhibitor had durable responses.

But I could not see what OTHER KI were used?

Hmmm

Martyn

[AussieNeil Partner Founder Admin in reply to MartyR]

Ibrutinib to Idelalisib or vice versa . There's also ACP-196, but that's only in early trials...

[Cllcanada Top Poster CURE Hero in reply to AussieNeil]

And Ono/Gilead-4059 again in clinical trials... Gilead has Idelalisib (Zydelig) too ... so a swap between drugs from one company might be their plan... some time off...

[RK66]

For those of us in the U.S., will Medicare cover either of these treatments? I'm not sure what will or won't be covered by my Medicare and supplemental insurance plan when I need treatment. Has anyone had experience with it?