what was the reason/s that the use of strontium ranellate for treatment of osteoporosis was ceased?

[MayGodBlessYou]

in Australia at least

thanks

[Met00]

It hasn't been authorised in the US either, but is sometimes prescribed in the UK and Europe. There have been concerns that it may cause a heart attack, but in the UK at least it's been concluded that the risk is only to those with existing heart disease. There's a good article here that explains it all: en.wikipedia.org/wiki/Stron...

[fmkkm]

My understanding is the prescription form was the element of strontium combined with ranalate to help with absorption. This was found to cause blood clots in some people. You can still buy strontium citrate as a supplement on line. I take this with D, MK-7, and a plant calcium formula. My bone density scan has gotten better over 5 years but I have no proof why. I also walk a couple hours every day.

[Raleigh59 in reply to fmkkm]

how much strontium do you take each day

[walk21 in reply to Raleigh59]

I am prescribed 2g strontium ranelate each day

[Raleigh59 in reply to walk21]

I thought that’s not available anymore

my endocrinologist said for me to not take any strontium and I don’t know why but he said it could hurt my bones rather than help them. I tried to discuss it and he said I am not going to discuss this. But I know he doesn’t want h r t bc of risk of blood clot. He’s a very top Endocrinologist in my location.

[notanotter in reply to Raleigh59]

As I recall, the mineral strontium can enter the bones, sort of preventing the calcium from binding. You then have bones that appear to be mineralized but are not mineralized by the calcium your bones need. Early research was promising but I believe showed bones ended up more brittle. I’m sure I have mixed up some of this explanation, but strontium was a dashed hope for researchers in osteoporosis.

[Raleigh59 in reply to notanotter]

I thought strontium renelate was the dashed hope. I thought strontium citrate is positive .

[notanotter in reply to Raleigh59]

Strontium ranelate was the one a doctor might consider, so I thought that’s the one you were referring to .

I don’t think there’s any clinical trial data on strontium citrate or chloride. But it appears there are supplements being sold by retail online.

Personally, I am wary of a supplement because their composition is not regulated. The maker isn’t required to test them either. When there are a lot of desperate people, scammers jump in with all four feet. So, I gave up on that idea.

If you’re in the UK, you could make a case for using the generic strontium ranelate “Aristo”(?). A German generic drug maker bought the formula from the original maker after the precipitous drop in sales. The UK NHS allows SR to be prescribed for people who cannot tolerate any other drug option, as long as the person has a high risk of fracture and doesn’t have a risk for the conditions that appeared in later clinical trials - DVT and (coronary artery disease/ heart conditions).

[HeronNS in reply to fmkkm]

You do know that strontium, which is replacing some of the calcium in your bones, is heavier than calcium? It makes it harder to compare bone density and I think a calculation is usually made to account for the relative heaviness of strontium.

[MayGodBlessYou]

a dr i really admire mentioned strontium to help osteoporosis

[HeronNS]

It is really quite extraordinary that some drugs, like Prolia and Evenity, can be actively pushed on elderly people, especially women, in spite of black box warnings that side effects can cause death, but strontium is actively discouraged, although as far as I know strontium citrate (natural) version doesn't have the same issues as the manufactured (because it could be patented) strontium ranelate.

[MayGodBlessYou in reply to HeronNS]

it's heart break for my Mum and for me, very helpless

[Raleigh59 in reply to HeronNS]

I think the black box warning are bc of animals that had reactions but humans haven’t or it so rare that they think one in 100k people it’s worth the risk

[Raleigh59]

I personally think 250 mgs of strontium citrate is good to do but my dr doesn’t want me to