Another study supporting Niagen for Ataxia. - Ataxia UK

Ataxia UK

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Another study supporting Niagen for Ataxia.

sunvox profile image
31 Replies

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuro- protection in Spinocerebellar Ataxia Type 7

pubmed.ncbi.nlm.nih.gov/318...

I'm just about to walk my dogs so this post will be short. The article above is behind a paywall, but I purchased it and will share it with anyone who asks. Long story short the study is saying what I have been saying for years. The fact that NIAGEN boosts Sirt1 activity is key, and that fact separates Niagen from all other forms of vitamin B3 which are Sirt1 inhibitors, AND Niagen is likely helpful for many, many central nervous disorders, AND this activity is due to Niagen's ability to dramatically boost NAD+ production in humans.

One interesting fact from this study was that although they actually tested Niagen in mouse models of SCA7, they also tested human brains (post mortem) for signs that what they were seeing in mice as the problem that was fixed by Niagen did in fact occur in humans as well.

Anyways, more later.

Cheers,

Joe in NY

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31 Replies
Rhiny99 profile image
Rhiny99

Thank you for sharing; I always look forward to your posts!

Namitaytrev profile image
Namitaytrev

Hi Joe- could you forward me a copy of the study? Great news! Ihave been taking Niagen for 2 1/2 yrs now. I’ll email you so you have my email to respond.

sunvox profile image
sunvox in reply toNamitaytrev

Hi Nami-

Of course, I will send it right away :)

EDIT: I asked about your B12 intake, but I was confusing B12 and B1 for a second . . . silly me.

Also, when next you see your doctor would you mind asking why he feels so strongly about Ubiquinol?

Thanks a bunch,

Joe

kuchee profile image
kuchee in reply toNamitaytrev

Good day Nami! could you pls. share your view of using Niagen? wondering if you can help finding the suppl. (niagen) in Pakistan. I have SCA1. Thought of having positive after using. I am positive. :)

ww-wibblywobbly profile image
ww-wibblywobbly

Do you have SCA 7 sunvox?

sunvox profile image
sunvox in reply toww-wibblywobbly

Hi Alison,

No, I have SCA1, but SCA7 is so very similar, and the study actually examined a cellular process that is similarly broken in many neurological disorders. That is one reason why Niagen is in multiple human clinical trials for several different disorders including, Parkinson's and Mitochondrial Myopathy

I have read your posts on your hard work going to therapy for a decade now, and I can think of few people on this forum who can offer better inspiration to get out there and do the best they can. You inspire us all :)

Joe

Happyfacexx profile image
Happyfacexx

Thanks for sharing I’m about to order some

kuchee profile image
kuchee

Hi Joe,

Appreciate your input to forum as always. Can you share the article with me please?

Where do you guys buy Niagen?

Rhiny99 profile image
Rhiny99 in reply to

Tru Niagen has a website. They did offer a special not too long ago. You can also buy from amazon. It is expensive.

simon111 profile image
simon111

Hi Joe

Will it benefit friedrichs ataxia

Thank you

cocobibi profile image
cocobibi

thanks for sharing this info, I'd love to see this and pass it on to the consultant too. Do you know if it's also effective for SCA2 by any chance. My husband is ready to try anything.

Does anyone have any experience/good result from complementary therapies and if so which ones?

Many thanks, :)

SilentEchoes profile image
SilentEchoes

I would like to read the article. I have MND/ALS, and one of my disabilities is sensory ataxia.

With gratitude,

SE

kuchee profile image
kuchee in reply toSilentEchoes

Hi SE,

Could you share the symptoms for sensory ataxia and how you are coping with it?

I have unknown SCA with sensory effects and I am trying dealing with my daily regimen of medicine and exercise.

Thanks a lot.

SilentEchoes profile image
SilentEchoes in reply tokuchee

For ataxia, you do the Romberg test. Stand with your back to a corner and put a chair in front of you without touching either one. The idea is to protect yourself from falling if you lose your balance while doing the test. Stay safe. You stand still with your feet together and arms at your side for 30 seconds. Do you sway? Now close your eyes. What happens? For me, closing my eyes causes severe swaying, it's loss of proprioception, the sense of where your body is located in space. This is called sensory ataxia.

I start physical therapy next month, there is evidence that the brain can be retrained and ataxic symptoms improved.

SE

kuchee profile image
kuchee in reply toSilentEchoes

Thanks a lot for feedback and yes the swaying symptoms are there too.

I am having heavy steps while walking and can't jump a little high too.

Balance problem while walking seems drunk.

Any advice on meds, supplements or exercise would be highly appreciated.

My current supp regimen includes;

> 1 g, Thiamine (recently commenced) (AM/PM)

> 100 mg, COQ10 (AM)

> 300 mg, GABARDINE (PM), for sensory ataxia

> Turmeric powder Tea (AM)

> Vitamin D

+ 6-Day week 30 min. trade mil, STRENGTHENING, YOGA, Meditation.

I feel much improved than was 6 month before but only having few/ above symptoms. Trying to overcome those too.

Thanks for advice.

SilentEchoes profile image
SilentEchoes in reply tokuchee

What is unknown SCA? I thought SCA was genetic and confirmed by testing. Are you certain it's not a different neuromuscular disease?

You should also look into sulforaphane from broccoli sprouts.

kuchee profile image
kuchee in reply toSilentEchoes

The unknown mean i didn't have any tests as gene testing was not recommended by my neurologist but this genetic mutation as from my mother.

By symptoms and having some research I realize that i have SCA1 with sensory effects.

Kindly elaborate your experience for SALFORAPHANE, as this is my current list of research.

Many thanks

ilhana profile image
ilhana

Please send me the report and if you would be kind enough to tell me which niagen - what brand? Thanks for your help

Rhiny99 profile image
Rhiny99 in reply toilhana

Sunvox has been banned from this forum so he can’t respond. Tru Niagen has a website and you can purchase from Amazon. I have been taking this along with other supplements and can report that my early symptoms have improved. But please consult your physician.

ilhana profile image
ilhana in reply toRhiny99

Why has he been banned? Thank you,I will consult my doctor. What other supplements do you take? Thank You again

Rhiny99 profile image
Rhiny99 in reply toilhana

Look at the forum’s latest posts and you can read about it.

Vitamin b12

Calcium with D

Curcumin

Vitamin e

High dose thiamine (b1)

Taurine

Tru Niagen

Trehahose or Xylitol with my coffee

Magnesium at night for cramps

Exercise and yoga daily

ilhana profile image
ilhana in reply toRhiny99

Thank you so much

Rhiny99 profile image
Rhiny99 in reply toilhana

I also take ubiquinol (coq10)

ilhana profile image
ilhana in reply toRhiny99

Thank you!

ilhana profile image
ilhana

Rhiny99 pls can I have your email thanks

Rhiny99 profile image
Rhiny99 in reply toilhana

You can send me a pm. I’m sorry, I’m not comfortable sharing my email address at the moment. Take care.

ilhana profile image
ilhana in reply toRhiny99

I just wanted to know what Brands you take and how much of the supplements and share with you my regimen. I also take supplement like ubicinol, pqq, tumeric, melatonin etc some of yours but not all, Accupuncture, Bioresonance, rTMS,biofeedback , Has see functional dr exercise and do weights, pray

ilhana profile image
ilhana in reply toRhiny99

Can you Tell me what Brand’s and amounts pls? Sunvox also recommends thiamine how much and what brand?

ilhana profile image
ilhana

I just wanted to know what Brands you take and how much of the supplements and share with you my regimen. I also take supplement like ubicinol, pqq, tumeric, melatonin etc some of yours but not all, Accupuncture, Bioresonance, rTMS,biofeedback , Has see functional dr exercise and do weights, pray

ilhana profile image
ilhana in reply toilhana

This is for rhiny99

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