Edoxaban to Apixaban?: Some time ago I... - Atrial Fibrillati...

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Edoxaban to Apixaban?

Rog65 profile image
20 Replies

Some time ago I read a post that said Apixaban was superior to Edoxaban. I’ve been taking Edoxaban for several years and have no side effects. Can anyone advise? Are there long term problems that I should be aware of? Any advice / comments would be gratefully received.

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Rog65 profile image
Rog65
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20 Replies
BobD profile image
BobDVolunteer

My understanding is that all the DOACs are of similar efficacy (provided taken in strict accordance with instructions,) so it is a matter of which best suits you. I understand that Edoxaban is more advantageously priced which may be why many centres prefer it. If it ain't broke why fix it?

Rog65 profile image
Rog65 in reply toBobD

Thank you.

jeanjeannie50 profile image
jeanjeannie50

My very experienced AF nurse, told me that a few years ago she would never accept anything to be as good as Warfarin. She's changed her mind now and says that Apixaban is the best.

Jean

BobD profile image
BobDVolunteer in reply tojeanjeannie50

I believe a very slightly better risk of intercranial bleeds. Jean.

Rog65 profile image
Rog65 in reply tojeanjeannie50

Thanks. Did the nurse give any reasons?

jeanjeannie50 profile image
jeanjeannie50 in reply toRog65

It was all based on reports she'd read.

Rog65 profile image
Rog65 in reply tojeanjeannie50

Thanks again.

mjames1 profile image
mjames1

I also thought Aphixaban was the superior NOAC. However, this recent study suggests Edoxaban may be.

pubmed.ncbi.nlm.nih.gov/347...

Jim

Rog65 profile image
Rog65 in reply tomjames1

Thank you, Jim.

MarkS profile image
MarkS in reply tomjames1

I did notice that three of the researchers of that study worked for Daiichi, the manufacturers of Edoxaban. Having said that I don't think Apixaban is superior. There were problems with the main Apixaban trial, Aristotle, which, of course was funded by the manufacturer: cardiobrief.org/2011/09/23/...

Rog65 profile image
Rog65 in reply toMarkS

Interesting! Thanks for your reply.

mjames1 profile image
mjames1 in reply toMarkS

Good catch and good points, Mark. I sometimes wonder about a lot of these trials, as well as even medication guidelines. Influence of the drug industry is heavy.

Jim

javo123j profile image
javo123j

I've just been moved from Apixaban to Edoxaban purely due to costs by my doctor's but I myself have noticed no difference

Rog65 profile image
Rog65 in reply tojavo123j

Thanks for this.

Squidgybod profile image
Squidgybod

I was put on Apixaban but I started to lose the hair on the top of my head and my legs and I got itchy blisters on the soles of my feet. Three weeks on Edoxaban and it all seems to be improving.

Rog65 profile image
Rog65 in reply toSquidgybod

Thanks for your reply. All these answers are very reassuring!

Fullofheart profile image
Fullofheart

I've recently been changed from edoxaban to apixaban. The only reason I was given is due to the interaction with dronedarone. Apixaban needs to be reduced alongside dronedarone whereas apixaban doesn't.

Rog65 profile image
Rog65 in reply toFullofheart

Thanks for the info- much appreciated.

Fullofheart profile image
Fullofheart in reply toRog65

No problem at all..Also worth saying I've had no problems at all with the switch and I'm generally pretty meds sensitive.

Best of luck to you!

gordeno8 profile image
gordeno8

If the tablets that you take aren't causing problems stay on them .if you do have any ,tell your doctor.i take apixaban (7years now)also lansoprazole for acid reflux.mo problems.

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