Started clinical trial through Honor Health Research in Scottsdale yesterday. Day one was intense with multiple labs and EKG's after his first dose. Appointments today and tomorrow without the med but with follow up labs/EKG's. Friday's appointment will be the start of daily medication. Bone scans and CT scans will be done every 6 weeks.
Scans were done last week prior to starting this trial. The CT scan showed the lesion on his liver doubled in size from his January scan with 3 new lesions. It's been 6 weeks since my husband last had chemo. And it was failing before that, so I guess I shouldn't be surprised but it was disappointing to see that. Upsetting is probably more truthful. We're optimistic about this trial. This team is cautious and thorough. We are grateful for this opportunity. I was nervous about this being a phase one trial at first. Feeling better about this as we go through it.
Will post with updates when we get them. Seems to be a few here on HU on clinical trials right now. Best of luck to all of you. Encouraging to know there's so much on the horizon.
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Yadifan
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I'm on a clinical trial for an AR degrader ARV-766. Lots of visits and labs as you describe. PSA dropped 50% after 2 weeks, another 10% at 4 weeks, BUT, bounced back up to 2 week level at 6 weeks. Bone pain, which was pretty bad before starting trial and had largely subsided, is starting to get bad again. Not a positive sign. I go for scans and labs next week, so will see. Had great hopes for this...... I wish you success.
Thank you. We have high hopes also. I think you need to when you enter these trials. This clinical trial team has talked about gauging the success by results of scans more than anything else. But it's hard not to pay attention to body pain and PSA results. Please post after you get your results from scans. Do you have a treatment lined up if this one doesn't work.
My husband completed the 2nd set (of3) of the Provenge transfusion/infusion therapy yesterday. His onc does not have a lot of clinical experience with it so is right with him to check all the SEs and procedural process. But she also confers with a consortium of oncs who meet regularly to discuss their patients. Together they decided it was a good “next treatment” for him after the Abiraterone stopped working.
So, one more of these sessions to go in 2 weeks and then we hold our breath and wait for scans to show if his immune system has kicked in against the 3 bone lesions that appeared.
He has hit the 4 year survival mark, so of course aiming for at least double that.
It is a harrowing path! And we try to keep life normal in between the roughest spots and as Warren Zevon said, enjoy every sandwich!
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