Olaparib time to lower PSA

[Seebs9]

Hello all,

Anyone know how long it take for Olaparib ro lower PSA? All I can find is that it takes 90 days to start working.

Thanks

[God_Loves_Me]

please add source

[Seebs9 in reply to God_Loves_Me]

Drugs.com

[mrscruffy]

worked for me in 6 weeks. Knocked down PSA from 1.7 to 0.14. My MO was part of Lynparza development team. He told me it is a fast acting drug

[Seebs9 in reply to mrscruffy]

Thanks Mrscruffy, I've been on it 3 weeks and PSA has gone from 48 to 198. Good thing I'm talking to my Onc today...

[mrscruffy in reply to Seebs9]

Good luck, hope he had good info for you. BTW what doe are you on. MO lowered my dose to 450 a day down from 600

[God_Loves_Me in reply to mrscruffy]

do you have mutations?

[Seebs9 in reply to God_Loves_Me]

Yes, PIC3 or something like that. ONC said it should work even though its not BRCA.

[Seebs9 in reply to God_Loves_Me]

The exact mutation is PALB2

[mrscruffy in reply to God_Loves_Me]

BRCA2

[Seebs9 in reply to mrscruffy]

I talk to Onc in about an hour. Taking 600mg per day.

[mrscruffy in reply to Seebs9]

600 mg gave anemia and MO worried about bone marrow thus the dose reduction. Going to push for 300 mg next month

[OsloN in reply to mrscruffy]

I do the same, 300 mg, works fine