Prostate Cancer Stems Cells/ what kills them?

[icanwintwice]

I have done my duty. Radiation to my lymph nodes, and 24 months of Lupron and Erleada. Now I wait!!!!! yikes.

Is there any way to kill Prostate Cancer stem cells? I have read a little about possible advances in killing cancer stem cells. What about prostate cancer stem cells. Im hoping to find something that might prevent a third attack from prostate cancer? Maybe I can kill them before they form the next tumor.....any thoughts?

thanks in advance for any advice!

[Tall_Allen]

Here are a few clinical trials that target them:

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

[God_Loves_Me]

ADC ARX517 is answer..

[icanwintwice in reply to God_Loves_Me]

Is that a clinical study? or something like that. Please help me to look it up

[God_Loves_Me in reply to icanwintwice]

clinicaltrials.gov/study/NC...

Press release :

ir.ambrx.com/news/news-deta...

[God_Loves_Me in reply to God_Loves_Me]

Also Acquired from Johnson and Johnson for 2 billion

[icanwintwice in reply to God_Loves_Me]

The clinical trials your sending me relate to CRPC. I am not castrate resistant! Does that make a difference

[God_Loves_Me in reply to icanwintwice]

No it’s ADC. Still you are eligible and no serious side effects. ADC stays is body for 8 to 12 days and keep killing cancer skill .

[NanoMRI]

I have been taking supplements, keeping my ferritin level down and Vit D level up, all doc guided, since my salvage lymph node surgery, over six years ago. Yes, I may be wasting my monies and simply coloring my urine a bit, but so far so good. These are some IMO interesting reads - hope this helps. All the best!

pubmed.ncbi.nlm.nih.gov/321...

pubmed.ncbi.nlm.nih.gov/296...

ncbi.nlm.nih.gov/pmc/articl...

[podsart in reply to NanoMRI]

why low ferritin?

[NanoMRI in reply to podsart]

Note, this is outside of common clinical practice - certainly doctor guided in my case. There is some 'evidence' that levels at the top of standard range, and higher, are associated with metastatic prostate cancer. My values had been over 300 ng/mL, top of 'standard range'. I use therapeutic draws to bring mine down to lower standard range. By doing this we stumbled upon my having hereditary hemochromatosis - for which the treatment is therapeutic draws. So now, even if this does not help with PCa, I will be doing therapeutic draws anyways.

[podsart in reply to NanoMRI]

thanks ; good luck

[Teufelshunde in reply to NanoMRI]

I take all those in the first study. Make sure sulforaphane is not glucoraphanin or other precursor to pure sulforaphane (I use BROQ per clinical study) I would add Fisetin 500mg 3x day for 2 days every 2 weeks per Nal. Strongest "senolytic" to be found. I did see one recent study which I cannot find now reiterating that but as the second strongest. Here is another possibility that I have in my notes. Don't know the author and I dont take this but seems interesting:

Neem Leaves - Friends who are interested in how the chemical NIMBOLIDE found in Neem leaves kill androgen independent Prostate cancer cells can read on PubMed articles: Oral nimbolide reduces prostate tumour size by up to 70%, decreases metastasis 50% (medicalxpress.com)

(1) Nimbolide inhibits androgen independent prostate cancer cell survival and proliferation by modulating multiple prosurvival signaling pathways ....By Singh P R et al (2016)

(2) Anti proliferative and apoptosis inducing effects of Nimbolide by altering molecules involved in apoptosis and IGF signaling via PI3K/ Akt in prostate cancer (PC3 cell line)

Now, Neem leaves contain Nimbolide and Nimbolide kills Androgen resistant cell lines such as PC-3. So its good for men who have castration resistant PCa.

[NanoMRI in reply to Teufelshunde]

Not familiar with Fisetin - will study. The sups I take are doc guided. The sulforaphane I use is from Avmacol, glucoraphanin and Myrosimax blend. Did a quick read on glucoraphanin - have yet to find anything about not being this? Can you share more?

[Teufelshunde in reply to NanoMRI]

I use BROQ. See the study below that used this product (the French version) and the results basically stopped PSA rising in guys with reoccurrence. When there is a double-blinded, randomized, placebo-controlled trial (the "gold" standard that people talk about) that gets the results we are looking for, and that product used is available, I use that product at the dosage used in the study. Period. If you go to Broq.life, look at the Independent Lab Test Results that show the bioavailable sulforaphane per serving (amount of sulforaphane that enters circulation in your body), you will rethink the Avmacol product, and almost every other one out there. There is a good explanation of how that is calculated. I have had people complain that it is expensive, but when you look at what you get in bioavailable sulforaphane, you would have to take five doses of the Avmacol product to equal one dose of BROQ. One warning. It is really strong. I have an iron stomach and if I dont take enough food/fat with each dose, I feel it. Anyway, something to think about.

aacrjournals.org/cancerprev...

[NanoMRI in reply to Teufelshunde]

thank you very much - a good example of benefit of HU. I of course will do my own due diligence and run it by doc.

[Teufelshunde in reply to NanoMRI]

As it should be.👍

[Researchshortcut in reply to NanoMRI]

Could you tell me the dosage of genistein you are taking? I am considering the addition of this flavone to my others mentioned in the "Big Five". Dose is a bit murky. Thanks, Jeff.

[NanoMRI in reply to Researchshortcut]

seems to me dosages/absorption/effectiveness are bit of a guess. Mine are doc guided - not necessarily fully supported. Started with 125mg twice a day over three years ago. Monies spent, lots of urine ;), all I know is my usPSA is holding very low stable 0.03X range, with all imaging and blood biopsies 'clear'. Best, Keith

[Researchshortcut in reply to NanoMRI]

Kieth - Thank you for the response. I wish you continued success!!Jeff

[icanwintwice in reply to NanoMRI]

good information. Thanks so much!!

[j-o-h-n]

When I first saw your UserID I thought it was icanwincetwice.... Make those those tiny pricks wince.........Keep posting!!!

Good Luck, Good Health and Good Humor.

j-o-h-n