R223 - PSA 26 Doubled since February

[Janhpr]

My husband has had 3 treatments of R223, had to postpone 4th treatment because of flu.

On Monday had bloods taken in preparation of 4th treatment on 18th April 2024.

Blood results ALP 76, at started of R223 106, HB 92 down from 102, (has Proctitis and occasional bleed, calcium a little low, taken adcal twice a day, what is concerning is PSA 26, was 10.4 at start of R223 in December, told does flare with this treatment but once treatment stopped will come down, but is worrying, has little bone pain and quickly controlled with paracetamol.

Tinnitus has become a real issue, keeping my husband awake, I believe it might be stress related, seeing a Tinnitus specialist tomorrow, but understand no cure.

Another concern routine INR bloods done Tuesday INR 7, high, advised by INR nurse to stop Warfarin until Friday, further bloods on Friday hopefully down to lower reading. If had antibiotics may have gone as high as 4.6, but usually with regime of INR 2 - 3. On Warfarin as multi pulmonary embolism while having chemotherapy 2010.

We would be grateful of any thoughts or advice kind regards Jan & Tony

[GP24]

Ra223 usually does not lower the PSA value. That will rise while Ra223 works.

[Janhpr in reply to GP24]

thank you for your reply and explanation, reassuring

[Janhpr in reply to GP24]

Thank you GP24 for your previous reply, since 4th treatment Tony has felt very unwell, fatigue, bone pain in buttocks, mobility really deteriorated in this short period of time, waiting for recentnX Ray result, yesterday told by Radiologist result from last CT scan, progression in higher coccyx, Multi Disciplinary team decided to stop further R223, this is all very worrying would be grateful of any advice

[GP24 in reply to Janhpr]

Seems he has exhausted all treatment options. He should really try to keep mobile to avoid muscle loss and end up in bed.

What I can recommend is this clinical trial which is also offered in Britain: healthunlocked.com/advanced....

[Janhpr in reply to GP24]

Thanks again GP24, see this trial is at Christie Hospital Manchester so only 1.5 hours away. The NHS does not allow patients to contact providers directly. Tony has done trials before and been positive experience, but referral has to come from your Oncologist. Our local hospital presume because of funding only offers chemotherapy and our chap is not very willing to make a referral regarding trials or 2nd opinions. Have you got a email contact in the UK and then if the response is positive will approach the Oncologist for a referral

[GP24 in reply to Janhpr]

Mrs Cook is in charge of this trial at Christie. You could email her.

christie.nhs.uk/patients-an...

[God_Loves_Me]

I am NOT a Doctor. Here are my opinions, and I request that you discuss

with the doctor.

R223 will raise your PSA and It is not design to lower PSA. I understand that a PSA number is a way to track things.

Coordinate with MO, request multiple scans over six months, and track comparisons.

PSA will become unreliable numbers for the next couple of months..even one year

PSA is reporting dead cancer cells, too. That's the reason the number is not reliable anymore now.

[j-o-h-n]

Seeing Tinnitus specialist tomorrow, but understand no cure. Only way to beat it is by using your mind to ignore it..... DON'T THINK ABOUT IT!!! (Like thinking about your ex-spouse)....

Good Luck, Good Health and Good Humor.

j-o-h-n