Dear Friends, This is hot of the press. One of the mechanism of metastatic spread is that tiny pieces of broken cancer cells circulate in blood ..they contain Cancer cell DNA and are called Chromatin pieces. These tiny pieces of chromatin enter into healthy cell and transform them into Cancer cells. Thus a seed is planted for growth of a metastatic spot.
Medical Scientists at one of India's top cancer research institute (Tata memorial Cancer center) found that if a combination of RESVERATROL (the that Red Wine substance) ...if taken along with a very very small dose of Copper....it can stop these tiny chromatin pieces from entering healthy cell and also eliminate them. Copper multiplies power of Resveratrol several fold.
The research on mice has shown this to be true. Human clinical trials are now going on. I was taking Resveratrol capsules ...all I did was added Copper capsules (2mg) a day. I hope this is proven on humans and that will be a very cheap way to slow down mets...they say it will cost $ 1 a day.
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Resveratrol is very safe particularly if taken in natural form. Copper has to be in small amounts. A tablet will be available in India in June-July. Sale price will be $1 a day.
Copper is cheap and can be purchased without a prescription. My wife have both tried 2mg pills a while back. I was fine with it but she got a very bad headache that day and never tried it again.
After searching "resveratrol" on HealthUnlocked and elsewhere makes me very skeptical of its positive effects. It may even cause harm. I suggest anyone considering using it do thorough research. There are some very questionable claims made about resveratrol and it has a shady history.
REVISED: At least Resveratrol seems to be positive for health and aging and doesn't do harm. Maybe it's worth a shot?
Ha. I eat at least 3 of the first 4 ingredients listed for copper every day and the only alcohol I ever drink is red wine (after taking 1200mg NAC and 125mg Vitamin C to limit acetaldehyde production during ethanol metabolism.)
I'm convinced there is no nutraceutical silver bullet but it's not about cure it's about delay to give time for new therapies and drugs to be developed.
Not that I think a couple of glasses of red wine is a big source or reservatrol. I initially passed on adding it to my supplement stack due to inconclusive evidence out there but this may be a game changer.
.9 for healthy individuals but pca patients 2 mg seems to b ideal along w the resveratrol. I drink 2-3 glasses of red wine daily but am going to incorporate the added resveratrol to get the rec dosage..
Be careful with the wine consumption… at the end of ADT I got borderline fatty non-alcoholic liver, NAFLD, just from eating too many carbos. karger.com/uin/article-abst...
Years ago I read Jane McLelland's, book. I even met with her in NYC. I was taking all sorts of supplements. Couldn't really tell if they had an effect. I did just order copper 2mg . Thanks for the heads up.
I would say if lack of substantial toxicity is PROVE, try whatever.....but don't discard SOC proven treatments, unless the potential toxicity of the SOC outweighs, for the individual, the slight possibility of benefit...eg, increased life expectancy by 4 months but with likely horrible QOL for those extra 4 months???
This succinctly sums up my overall attitude about using a multi-pronged, common-sense approach to dealing with Prostate Cancer. Consider novel approaches that do no harm but don't use them as a substitute for SOC. I would add to make sure to check for any potential interactions with drugs you are taking such as blood thinners, high blood pressure or statin medications which are very commonly used these days. For example, supposedly berberine can lessen the bioavailability of Losartan high-blood pressure medication which I take the lowest dose of so I switched from taking it in the afternoon after lunch to first thing in the morning which is 12+ hours since the last time I took berberine (with dinner).
The problem is most general practitioners (and probably MOs) don't have an encyclopedic knowledge of interactions (this also may make them unnecessarily over-cautious) but these days if they record everything you take in their clinic's computer system I think the system will analyze and bring up any red flags. Typically a Physician specializing in Integrative Medicine is more up on supplement interactions. But I don't trust the physician or the computer to do a thorough check on everything I take.
For example, a Google search for: curcumin drug interactions (I always go to the drugs.com page) shows it has moderate interaction with aspirin, Cymbalta and Eliquis.
You want to hear the truth ..the truth is that developing nations billions of human being are unable to afford extremely expensive western medicine. The Goverments in these nations are funding such cheaper alternatives to help their people. Prime examples are China, India, Iran, many african nation , Brazil and some Latin countries and so on. In these nations BIG pharma has much less influence to stop such research because of Govts and peoples backlash. In fact, the research Center which published this research is largely funded by Govt Of India. A declining West can be very bad for its own citizens and of rest of the World, ...more Inflation, more Wars, more bullying to stop or at least slow the decline. Enough said..some people may get offended and my intention is not to offend any one..Dear friend.
Thanks buddy, I agree with your thoughts, I honestly feel that we are lab rats and the cure is already available, but its not economically viable to let's us live.
good source! I hope they will soon try with prostate...but we need to be careful
" In this review, we discuss the metabolism of copper in the body and summarize research progress on the role of copper in promoting tumor cell growth or inducing programmed cell death in tumor cells."
pterostilbene is demonstrating many of the same, and perhaps additional, benefits in recent research and has at least four-fold greater bioavailability.
I'll have to do some research, I'm all for making life hard for these suckers.
Another simple addition to daily diet is low dose aspirin, it increases resolvins which are effective at clearing up dead cancer cell debris where mets can develop.
Best to take with omega 3 supplements.
Be careful though if you are on blood thinners, best not to mix them.
Aspirin was one of those things I was on the fence about. Initially it looked promising but systematic meta-analysis of studies didn't show significant benefit of PCa patients. Some did some didn't and the benefit was small for ones that did. I don't recall in the several studies I read remembering the word resolvins though!
So I ended up not including aspirin due to lack of conclusively positive evidence for pre-existing PCa patients combined with the fact I take Dihydroberberine before meals which has mild effect on blood clotting to a much lesser degree though than blood thinners. I'm not sure about dosage relative to action on resolvins but many people are unaware that as little as a half baby aspirin EVERY OTHER day will reduce TXA2 by close to 90%. If effect on reduction in TXA2 is a surrogate marker for increasing resolvins, a half baby aspirin a day (41 mg) may be plenty. Although bleeding time differences were very similar from 30mg to 81mg.
Do you have any links to studies regarding aspirin increasing resolvins and cancer?
Here's info on aspirin I initially ran across that is comprehensive for anyone curious on the subject:
"A total of 10 eligible articles were used in our study. The pooled results showed that PC patients who used aspirin or taking aspirin did not have lower PCSM than those who had not used (HR =0.89, 95% CI: 0.73–1.08, P>0.05). In subgroup analysis, we found that taking aspirin before diagnosis of prostate cancer and taking aspirin after diagnosis of prostate cancer did not have significant association with PCSM. (pre-diagnostic use, HR = 0.88, 95% CI: 0.72–1.06; post-diagnosis use, HR = 0.88, 95% CI: 0.67–1.17). In addition, we found no significant association between aspirin use or its duration and the risk of PCSM. Another important result demonstrated that aspirin use was not associated with risk of PSCM in either high risk (T ≥ 3 and/or Gleason score ≥ 8) or low risk PC patients(low-risk PC, HR = 1.05, 95% CI: 0.81–1.35; high-risk PC, HR = 0.97, 95% CI: 0.75–1.24)."
Baby aspirin 1 to 2 times a week can keep clotting under control. As we all know that Cancer is a Hypercoagulable condition...means there is increased tendency for clot formation. Asprin's biggest fault is its TOO cheap.
Great information. Has me reconsidering aspirin. I read the last two studies before. Given much of what is discussed can only help slow down and not speed up cancer, unfortunately most all the evidence is in-vitro or mouse studies that drive those conclusions. Usually there's a temporary increase in PSADT at best when these things are given to humans. There's nothing I've seen so far offering conclusive evidence (other than surgery and radiation) that can indefinitely halt the progression of pre-existing prostate cancer let alone get rid of it.
The first three articles you linked to are rather general but encouraging. Assuming I didn't glance over it, is there anything more clinical published that investigates the aspirin dosage necessary for an adequate response specific to resolvins?
copper, as iron, is one of those minerals that up to a certain amount are good against cancer but over a threshold are promoting cancer (like vitamin D that must be within a range to do good)…and we still don’t know the dosage as we are not rats. My suggestion would be to wait at least for the first results from the clinical trials mentioned above.
"The team also carried out another study involving head-and-neck cancer patients to find out if the aggressiveness of the cancer could be controlled. “Our study has found that we can minimise the aggressive biological behaviour of cancer,” said Dr Pankaj Chaturvedi, oral cancer surgeon and deputy director, TMC, who led the study. The team’s findings have been published in various peer-reviewed journals.
TMC has tied up with a nutraceutical company to commercially produce the “residue-removal agents”, also called chromatin-degrading agents. The nutraceutical should be ready for sale in June or July.
Dr Mittra emphasised the need for further large-scale studies but expressed optimism about the possibility of curing cancer rather than just treating it. “We now need to test it on humans to understand how best we can improve the outcome of our patients, and if possible, the outcome of the general population of India,” said Dr Rajendra Badwe, Professor Emeritus, TMC, who is also part of the studies on resveratrol and copper."
Plus mostly say it's just to help people undergoing chemo, so it's a temporary solution while those chromatins get degraded.
Very good point. I like to research stuff and I've been constantly frustrated how many studies involving nutraceuticals conclude with saying something like "promising evidence" and "requires further larger scale studies" and then there are none! But why? Because of lack of funding since the results are usually not going to produce profitable patented drugs. It's a shame. Also because there are a few things studied extensively that have shown some moderate benefit but aren't a cure. The typical problem is you can get high enough concentration in a mouse or a cell culture dish to get big benefits but not in the human body (or at least not without bad side effects.)
Of some of the more popular things you see people bring up, what little if any human studies there are they have typically one or both of the following aspects that should raise eyebrows: (a) They are being bankrolled by a (or soon to be) supplement company - which sounds to be the case here, and/or (b) they have no human studies or the one they have is a very small number of subjects. This is not to say there isn't a potential breakthrough here. Anything is possible. But the nutraceutical industry has exploded because they only thing the FDA does is recoginize them or not as Generally Regarded As Safe (GRAS) and not if they have been proven to be effective. Everyone is looking for the non-pharmaceutical, proverbial "magic bullet"
This is exactly what I meant, copper can be a friend or a foe according to the quantity taken and also the kind of cancer.
" In this review, we discuss the metabolism of copper in the body and summarize research progress on the role of copper in promoting tumor cell growth or inducing programmed cell death in tumor cells."
Ok, somewhat hesitant to wade into these waters....and it was YEARS ago, but my husband was in a prostate cancer clinical trial that involved "copper chelation." (I think he may have been taken out of it early because it wasn't doing anything. I can't tell you what year it was.)
So, I just "Googled" copper chelation and found this article from 2020:
This sounds promising or for me atleast up lifting as I start my day. Cashews contain copper other nuts also. Those two supps should be safe Thanks good stuff Ps I'm on Amazon right now, lol Stopped for a Rethink , after reading others comments on copper think it's best to wait for more positive finding. Thanks all
Cell-free chromatin particles (cfChPs) that circulate in blood, or those that are released locally from dying cells, have myriad pathological effects. They can horizontally transfer themselves into healthy cells to induce DNA damage and activate inflammatory and apoptotic pathways. It has been proposed that repeated and lifelong assault on healthy cells by cfChPs may be the underlying cause of ageing and multiple age related disorders including cancer. The damaging effects of cfChPs can be minimized by deactivating them via the medium of ROS generated by admixing the nutraceuticals resveratrol (R) and copper (Cu). The antioxidant R acts as a pro-oxidant in the presence of Cu by its ability to catalyse the reduction of Cu(II) to Cu(I) with the generation of ROS via a Fenton-like reaction which can deactivate extra-cellular cfChPs. This perspective article explores the possibility of using the damaging potential of ROS for therapeutic purposes. It discusses the ability of ROS generating nutraceuticals R-Cu to deactivate the extracellular cfChPs without damaging effects on the genomic DNA. As cfChPs play a key role in activation of various disease associated pathways, R-Cu mediated deactivation of these pathways may open up multiple novel avenues for therapy. These findings have considerable translational implications which deserve further investigation by the way of well-designed randomised clinical trials.
Copper although naturally found in the body can be toxic in higher levels. If you decide to go this route which I am skeptical of, you might be better off getting it naturally through food sources.
Some copper-rich foods include:
shellfish, such as crabs or lobster
organ meats, such as liver
seeds and legumes, such as sunflower seeds, cashews, and soybeans
beans
peas
potatoes
green vegetables, such as asparagus, parsley, or chard
Ed, I noticed that peanut butter besides providing copper was also listed as a good source of natural resveratrol - so I wonder if a daily peanut butter and grape jelly (resveratrol) sandwich (on toasted whole wheat - copper) would do the trick?
I'm just guessing but peanut butter and bacon probably isn't as good for you, which is a shame. Someone has to find a paper where bacon is a cancer fighter..
if I may invade this post...I said it for fun earlier, but I think that these elements from food would not even scratch the surface of the needed (sometimes tested) dose...500mg of resveratrol per day is a normal dosage for a supplement, but it really amounts to 80-110 bottles of wine per day, same goes for curcumin (curcumin has a very low bioavailability, you should literally eat it in huge amounts and 7-8 times per day to achieve significant blood levels of curcumin, nano and liposomal formulations do way better)
I personally tend to favor supplements also because they are more standardized: how much lycopene is in a tomato? how big the tomato? how ripe? what about the soil and water?...and so on, while hopefully (really hopefully) supplements producers are more consistent...
Funny you say that, as I finish my peanut butter, apple and strawberry whole wheat wrap, that’s been my go to for years now. I try to stay away from processed foods. Gotta get the all natural, no sugar peanut butter that has one or two ingredients, peanuts or peanuts and salt. I don’t know if it does anything as far as treating my cancer but it’s a good source of protein, has healthy fats and I get some fruit and fiber. And it tastes good with a cup of cold brewed coffee - my afternoon jam.
I do similar, but with sunflower seed butter instead of peanut butter for the Omega-6 oils. No sweetener, bit of salt. Trader Joe's used to have it, no more, now I use Amazon.
We just talked with nurse practitioner who works with our MO at Phoenix Mayo. We asked if there were any recommended supplements we could add to our regimen and she just said well none of these things have been proven as well as the SOC doublet and triplet therapies. Seems the standard line. I also have hubs taking black seed oil, lycopene, curcumin, ADK, NAC and liquid humid/fulvic minerals in his hot green tea. We also try to keep a pitcher of brewed green tea always available.
Most of the docs say this because most of them don't study any of the supplements. There is no desire for western med big pharma to spend the study money in order to promote use of a $10 supplement. That's why there is an opposition effort against the supps.
Looks interesting. Resveratrol has very low bioavailability. Its close cousin, sharing many of its beneficial properties, is pterostilbene, with four-fold greater bioavailability.
Interesting that they found extremely low doses much more effective than higher doses. Excerpt from one of the studies:
We observed that the two lower dose levels of R-Cu were more effective than the higher ones. It is noteworthy that the amount of R present in the lowest dose (level I) was ~90 times less, and that of Cu ~4500 times less, than those that are recommended by the respective vendors for use as health supplements. Thus, small quantities of a combination of R and Cu can generate sufficient oxygen radicals to have profound effects in terms of down-regulation of cancer hallmarks and immune checkpoints by targeting a hitherto unknown constituent of TME
apart from dosage, we all know that cancer does not exist...because, apart from the fact that we are all individuals (which is already a big fact) what can be good for lung cancer may not be good for prostate cancer and so on....
Copper ionophores, like resveratrol, have been studied for their therapeutic potential in various diseases, including cancer. These ionophores can modulate intracellular copper levels and have shown promise in cancer treatment by inducing cell death in cancer cells through mechanisms like cuproptosis.
It sounds like you have a tough time, reading your past posts.
Such treatments that work in mice may make you sick or not work, as they are very early in the trials. I would suggest discussing this with your oncologist to see if he or she thinks you have othe roptions that are more promising. Self treating in this way can be dangerous related to the treatment and the time spent using this, is something else might have worked better.
I take many supplements myself, adjunct to my oncologist's recommended main treatment. I do my research on treatments and then discusses the pros and cons with my doctor.
Interesting studies, but I would still be keen to see some more focus on the dosage and in particular, coppers role in tumour growth as it does seem to play an important role in that aspects of cancer growth.
I have not checked Copper level. Zinc and Copper levels go in opposite direction. High Zinc level reduces Copper level and vice versa. There are two different mechanisms ..whereby copper slows cancer cell growth..One..as medline described above..called cuproptosis..meaning actively killing cancer cells by copper getting inside cancer cells.. if taken with Resveretrol (Copper Ionophore) But the mechanism ..Tata cancer Institute scientists cited in paper is ...Tiny pieces of Chromatin ..after breaking up from dying cancer cells circulate in blood and starts lodging in different sites such as bone, lymph nodes etc. Causing new Mets. Copper+ Resveratrol is supposed to remove these tiny pieces of Chromatin and thus slow new met formation. I fear taking more than 2 mg of Copper per day.. so I stick with 2 mg tabs.
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