Bacteria based drug delivery, now this is something I have been following for a while

[Maxone73]

Still not applied to clinical trials for prostate cancer, more advanced for other kinds of tumors but still a new field. The idea behind it is simple: let's infect cancer with a bacteria that can infiltrate it and release a payload! Salmonella seems to work very well!

mdpi.com/1999-4923/15/9/2214

sciencedaily.com/releases/2...

[Scout4answers]

this is very promising:

"We had complete cure in three out of seven of the pancreatic mice models," Forbes says. "We're really excited about that; it dramatically extended survival."

The team then attempted to re-introduce pancreatic tumors in the immunized mice. The results were exceedingly positive. "None of the tumors grew, meaning that the mice had developed an immunity, not just to the ovalbumin but to the cancer itself," Forbes says. "The immune system has learned that the tumor is an immunogenic. I'm doing further work to figure out how that's actually happening."

In preliminary research, the team previously showed that injecting the modified Salmonella into the bloodstream effectively treated liver tumors in mice. They advanced their findings with the current research on pancreatic tumors.

Before clinical trials can begin, the researchers will repeat the experiments on other animals and refine the ID Salmonella strain to ensure its safety for use in humans. Liver cancer would be the first target, followed by pancreatic cancer.

"This is not just an academic exercise," says Forbes, whose grandfather -- for whom Ernest Pharmaceuticals is named -- died of prostate cancer. "I'm really trying to make a cancer therapy."

[Maxone73 in reply to Scout4answers]

Well, as usual, in vitro and in vivo does not matter...we are not 200 lbs mice ( I wish I was, basically everything works on them!), but yes...it somehow makes me feel better, the more ways they are considering to attack this cancer the better...let's hope for a clinical trial very soon.

[Maxone73 in reply to Scout4answers]

Let's be even more positive about oncolytic viruses (in this case it's the virus itself killing cancer, there is no payload from what I understand): "Results: As of October 1, 2021, 408 clinical trials on 31 OV products have been conducted, with oncolytic DNA viruses being the most investigated ones; phase I and phase II clinical studies accounted for approximately 80% of all studies. Published clinical studies have shown that OVs, such as H101, T-VEC, G47Δ, OH2, T3011, and Pelareorep, have significant anti-tumor effects on various tumors, with only mild adverse events. When OVs are used together with antiviral drugs in the clinic, drug interactions should be considered based on the sensitivity of OVs to antiviral drugs. Conclusions: OVs exhibit accurate oncolysis and favorable safety, and have positive effects on a variety of tumor treatments. It is worth noting that most of the OVs under development are still in their early stages, which is both a challenge and a promising prospect."

ncbi.nlm.nih.gov/pmc/articl...

[j-o-h-n]

Would "the Clap" help (no no not the Crabs)?

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 10/13/ 2023 3:59 PM DST -- Ex wife's birthday.