What's next for crumbling bones when Zytiga was not tolerable?

[dadsdrdawn]

My dad just stopped his Zytiga due to nausea, and other intolerable side effects. He just got his first two shots that they give for osteoporosis...due to a spontaneous fracture in his pelvis.

He's using a walker but has gotten relatively stronger from the day it happened a month ago...from doing exercises on his own at home.

He's 88 and LOVES live - and is very mentally powerful.

His body - not so much, but he powers through and is super driven to live to the fullest.

He's gone through many diff meds that didn't work.

Too many to mention.

The tumors are growing. One is smaller due to radiation.

Any new meds to help with shrinking tumors, or preventing bones from crumbling and weakening?

This has been a 16-year journey. And, none of us are ready to stop now...

I know that I have not given much "medical terminology" lately, but any input is welcomed!

Love and health and strength to you all,

Dawn

[Tall_Allen]

Taxotere? Xofigo? Provenge? Xtandi?

[dadsdrdawn in reply to Tall_Allen]

These are NOT chemo correct? The Karmanos Cancer Center Doctor in Detroit, said "he is at the end of the line" and the only thing that will set the cancer back is a "chemo drip"...Your thoughts please? And you can "detail it up" so I can have my parents ask specific questions as to if any of those are new options and THANK YOU!!!!

Dawn

[Tall_Allen in reply to dadsdrdawn]

Taxotere (docetaxel) is chemo. His oncologist should know what those medicines are.

[dadsdrdawn in reply to Tall_Allen]

I was asking you if you could give me any questions to ask if you don't mind.

My mom seems to think they said the ONLY options is chemo since he has a PSA of 1600.

I asked if the tumors have grown or if the bones are showing up as weaker than before and she "was not sure' but said the only option is a chemo drip.

thanks

d

[Tall_Allen in reply to dadsdrdawn]

Here are 4 questions:

Is he a good candidate for Taxotere?

Is he a good candidate for Xofigo?

Is he a good candidate for Provenge?

Is he a good candidate for Xtandi?

[fmh1]

Does your Dad take a calcium/vit D3/K2 supplement? I had chemo four years ago (Taxotere), followed by ADT since, and for the last three years my BMD has either stayed flat or increased with AlgaeCal, a plant-based calcium supplement with clinical support --- including even patients with severe osteoporosis.

[dadsdrdawn in reply to fmh1]

Yes, but going to make sure it is the plant based one, and the one that includes K2 - prayers for you! and thank you!

[fmh1]

100% plant-based, with D3, and K2 --- use this link to get 20% off your first order if you decide to buy: refer.algaecal.com/Frank4

[FourString]

I have been on Zytiga/Prednisone for over five years. I started applying Estradiol patches 1.5 years ago. Since the patches (four 0.1mg, twice a week) I have no nausea or hot flashes, better bones and far less fatigue. ALSO: no longer need a permanent catheter (or an intermittent one) because my prostate and all my tumors (metastases) have shrunken very significantly. Only side effect: a more feminine physique. Not that different from most 75 year olds, tho. Might be worth a try. There are studies validating.

[Jalbom4]

I finished a two year treatment of Lipton, zytigs and prednisone two years ago.

I had the usual side effects of testosterone blockade. I have no insights into zytiga.

I have done well with an undectable psa for almost 4 years, including six months on testosterone replacement.

I am unconventional in that I have been doing an ancestral diet, avoiding seed oils, sugar and carbs, and eating red meat every day.

Prior to developing oligometastatic prostate cancer I had reversed diabetes and Grave’s disease, and morbid obesity.

Perhaps my good result is due to the elimination of seed oils which block the tumor fighting p53 gene.

Chris Knobbe just published The Ancestral Diet Revolution, an excellent treatise

That you might find helpful.

[j-o-h-n]

God Bless your Dad (and You and your Mom).

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 08/04/2023 2:37 PM DST

[dmt1121]

You have not mentioned denosumabs being administered for bone strengthening. A Dexascan should have been done prior to taking Abiraterone to establish a baseline for his bone density. He probably already had osteoporosis or osteopenia before starting Abiraterone.

Xgeva and Prolia injections should have been recommended. Perhaps getting a second opinion from another oncologist would be wise.

Good luck!